Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions

Müller, Stefan A.; Treutner, K.‐H.; Anurov, M.; Titkova, S.; Oettinger, A. P.; Schumpelick, Volker

doi:10.1002/bjs.4316

Cited by 36 publications

(38 citation statements)

References 24 publications

(14 reference statements)

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“…However, during laparoscopy follow-up, no significant differences in adhesion formation were detected between these two study groups or controls. These findings are in agreement with reports by other authors [16,17] , who observed no benefits of the use of icodextrin over other substances for preventing adhesions in several experimental models. In contrast, Conroy et al [18] reported the significant efficacy of 4% icodextrin in rats compared to Ringer's lactate solution.…”

Section: Discussionsupporting

confidence: 83%

Efficiency of 4% Icodextrin in Preventing Adhesions to Spiral Tacks Used to Fix Intraperitoneal Prostheses

Bellón

Rodríguez²,

García‐Honduvilla³

et al. 2006

Eur Surg Res

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Background/Aims: This study was designed to evaluate the extent of adhesion formation to prostheses fixed with spiral tacks and to establish whether the use of Ringer’s lactate or icodextrin could prevent these adhesions. Methods:24New Zealand white rabbits weighing around 3,000 g were implanted with a 7 × 5 cm patch of ePTFE (DualMesh®) through amidline laparotomy. The prosthesis was fixed to the intact peritoneum using spiral tacks. Three study groups were established according to whether the animals were: implanted with ePTFE fixed with spiral tacks or implanted with ePTFE fixed with spiral tacks and simultaneously administered Ringer’s lactate or 4% icodextrin in the peritoneal cavity. Adhesion formation and prosthetic behavior at the prosthesis/peritoneal interface were evaluated and quantified by sequential laparoscopy performed at 3, 7 and 14 days. Results: Adhesions generally formed on the tacks and were classified as the fully integrated type. No significant differences were observed in terms of the extent of adhesions or of neoperitoneal thickness between control animals and those receiving Ringer’s lactate or icodextrin. Conclusions: (a)Prosthesis-fixing tacks induced adhesions; (b) the use of substances such as icodextrin or Ringer’s lactate does not seem to diminish adhesion formation, and (c) the use of icodextrin offered no benefits over that of Ringer’s lactate solution.

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Section: Discussionsupporting

confidence: 83%

Efficiency of 4% Icodextrin in Preventing Adhesions to Spiral Tacks Used to Fix Intraperitoneal Prostheses

Bellón

Rodríguez²,

García‐Honduvilla³

et al. 2006

Eur Surg Res

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“…Adezyonu azalttığını belirten çalışmalar olduğu gibi başarısız olduğunu belirten çalışmalarda mevcuttur. [2][3][4][5][6] Müller ve arkadaşlarının [21] yaptığı ça-lışmada ise peritonitli olgularda yapışıklığı azaltmadı-ğı gibi daha sık apse gelişimine neden olduğu bildirilmiştir. Çalışmamızda ise sonuçlar değerlendirildiğinde ikodekstrinin yapışıklık oluşumunu belirgin olarak azalttığı saptandı.…”

Section: Discussionunclassified

“…[1] Adezyon önleyici ajan olarak kullanılan %4'lük ikodekstrin solüsyonunun adezyonu önlemede etkin olduğunu belirten çalışmalar olduğu gibi aksi yönde görüş bildiren çalışmalar da vardır. [2][3][4][5][6] Gastrointestinal sistem anastomozları üzerine etkisi konusunda ise literatürde üç adet deneysel çalışmaya ulaşılmıştır. [7][8][9] Çalışmaların ikisinde anastomoz iyileşmesini olumsuz yönde etkilemediği belirtilirken bir tanesinde aksi yönde görüş bildirilmiştir.…”

Section: Bulgularunclassified

Effects of abdominal adhesion-preventing 4% icodextrin solution on healing of bowel anastomoses

Koç¹,

Dağ²,

Öcal³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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“…It persists for several days in the peritoneal cavity and is slowly absorbed by the lymphatic system into the systemic circulation, where it is broken down by amylase and metabolized to glucose (11). Several experimental and clinical studies have demonstrated the efficacy of ID in reducing postsurgical adhesion formation (11)(12)(13)(14)(15). In addition to these positive findings, the cheapness of the product is an advantage.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 4% icodextrin and auto-crosslinked hyaluronic acid gel in terms of efficacy and cost effectivity in preventing postoperative abdominal adhesions

Baskonus¹,

Maralcan²,

Gökalp³

et al. 2013

Gaziantep Med J

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This experimental study was designed to compare the effects and costs of 4% icodextrin and hyaluronic acid in intraabdominal adhesion formation in rats. This study included 30 healthy Wistar albino rats, each weighing 250-300 gr. Following cecal-ileal abrasion to rats in each group, the following treatments were applied: Group 1 (control, n:10) 5 ml saline irrigation; Group 2 (n:10) 5 ml 4% icodextrin solution; Group 3 (n:10) 3 ml auto-crosslinked hyaluronic acid gel. After 14 days, following a second operation, adhesion intensity scoring, histopathological assessment (inflammation, fibrosis) and costs were compared between groups. The lowest postoperative adhesion intensity score was found in the group 3 and the highest score was found in the group 1 (p=0.028). Group 3 had a non-significantly lower adhesion intensity score than group 2 (p>0.05). In terms of inflammation and fibrosis, group 2 had the lowest score, but there were no significant differences between all the groups (p>0.05). In terms of cost, 4% icodextrin is less expensive than hyaluronic acid. The results demonstrated that both hyaluronic acid and 4% icodextrin are similarly effective in reducing postoperative intraabdominal adhesions. In addition, 4% icodextrin is more cost-effective, which can be an advantage for clinical studies.

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Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions

Abstract: Phospholipids and icodextrin were effective in preventing re-formation of adhesions.

Cited by 36 publications

References 24 publications

Efficiency of 4% Icodextrin in Preventing Adhesions to Spiral Tacks Used to Fix Intraperitoneal Prostheses

Efficiency of 4% Icodextrin in Preventing Adhesions to Spiral Tacks Used to Fix Intraperitoneal Prostheses

Effects of abdominal adhesion-preventing 4% icodextrin solution on healing of bowel anastomoses

Comparison of 4% icodextrin and auto-crosslinked hyaluronic acid gel in terms of efficacy and cost effectivity in preventing postoperative abdominal adhesions

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