Experimental Chemotherapy of Schistosomiasis mansoni

Katz, Naftale; Pellegrino, J.

doi:10.1016/s0065-308x(08)60391-7

Cited by 7 publications

(1 citation statement)

References 65 publications

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“…However, in vitro studies do not necessarily reflect the responses of parasites in vivo. Indeed, some anti-schistosomal drugs are inactive in vitro (KATZ & PELLEGRINO, 1974). The present paper describes the in vivo effects of Astiban, Lucanthone, Hycanthone and Niridazole on the ultrastructure of the schistosome gastrodermis.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis

Clarkson¹,

Erasmus²

1984

J. Helminthol.

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The effects of Astiban, Lucanthone, Hycanthone and Niridazole on autophagic activities in the gastrodermis of Schistosoma mansoni were determined in vivo, using different dosage levels and dosage times. With Astiban, high levels of autophagy were observed in the gastrodermis 2 hours after an injection of the drug into the mouse, and this response had declined by 20 hours, marking a recovery by the parasite from the drug. Hycanthone and Lucanthone produced an autophagic response several days after the onset of treatment, and no recovery was observed in the morphology of the gastrodermis after the drug was discontinued. The effects of Niridazole on the gastrodermis were to produce the most dramatic ultrastructural changes after high doses and over several days of treatment. With all the drugs examined, gastrodermal autophagy was characterized by the formation of vacuoles containing cell components, lipid droplets and sometimes hydrolytic enzyme reaction product. The autophagic vacuoles appeared to be formed by the sequestration of cytoplasmic material by the basal membrane infoldings, and the transfer of enzymes into the vacuole from within the limiting membrane. The residues from intracellular digestion appeared to be emptied into the caecal lumen.

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Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis

Clarkson¹,

Erasmus²

1984

J. Helminthol.

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Progress and Prospects in the Conquest of Schistosomiasis

Werbel¹

1975

Israel Journal of Chemistry

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Schistosomiasis is a waterborne, snail mediated parasitic infection which afflicts over 200 million people. The disease has persisted since ancient times, and if anything is thriving in the shadow of technological progress. Some 50 years after the introduction of organoantimonials for treatment of the disease no entirely satisfactory curative, nontoxic agent for schistosomiasis exists. Recent progress with two novel types of extremely potent schistosomicidal agents, the nitrothiazolines and the 2H‐[1] benzothiopyrano‐[4,3,2‐cd] indazoles will be discussed. In particular the dissociation of toxic side effects from antischistosome activity via structure modification will be emphasized. Clinical evaluation of these agents will determine whether we have succeeded in this battle against one of the developing world's most pressing human health problems.

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Trematode Infections of Man

Campbell¹,

Garcia

1986

Chemotherapy of Parasitic Diseases

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Experimental Chemotherapy of Schistosomiasis mansoni

Cited by 7 publications

References 65 publications

Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis

Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis

Progress and Prospects in the Conquest of Schistosomiasis

Trematode Infections of Man

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