Experimental and theoretical study of biodirected green synthesis of gold nanoflowers

Jakhmola, Anshuman; Vecchione, Raffaele; Gentile, Francesco; Profeta, Martina; Manikas, Anastasios C.; Battista, Edmondo; Celentano, Maurizio; Onesto, Valentina; Netti, Paolo A.

doi:10.1016/j.mtchem.2019.100203

Cited by 18 publications

(17 citation statements)

References 45 publications

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“…Therefore, the experimental data were not far from the calculated ones, indicating the suitability of the non-linear first-order kinetic equation model. Release rate studies are important to control, tune and adjust the drug dose during a time-long therapy such as for diabetes [43], chemotherapy [44] and other chronic diseases as neurological [45] or inflammation diseases [46,47].To this end, mathematical modeling can provide valuable information on the mechanism of the release process [25].…”

Section: In Silico Predictionmentioning

confidence: 99%

“…Mathematical models represent a fundamental tool to optimally design new pharmaceutical systems, to study drug formulations and to evaluate in vitro and in vivo releases [23][24][25][26]. They rely on the model fitting of experimental data and equations and they enable a quantitative interpretation of the values obtained from a drug release assay [27].…”

Section: Introductionmentioning

confidence: 99%

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Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

et al. 2020

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In recent years, drug delivery systems have become some of the main topics within the biomedical field. In this scenario, polymeric microparticles (MPs) are often used as carriers to improve drug stability and drug pharmacokinetics in agreement with this kind of treatment. To avoid a mere and time-consuming empirical approach for the optimization of the pharmacokinetics of an MP-based formulation, here, we propose a simple predictive in silico-supported approach. As an example, in this study, we report the ability to predict and tune the release of curcumin (CUR), used as a model drug, from a designed combination of different poly(d,l-lactide-co-glycolide) (PLGA) MPs kinds. In detail, all CUR–PLGA MPs were synthesized by double emulsion technique and their chemical–physical properties were characterized by Mastersizer and scanning electron microscopy (SEM). Moreover, for all the MPs, CUR encapsulation efficiency and kinetic release were investigated through the UV–vis spectroscopy. This approach, based on the combination of in silico and experimental methods, could be a promising platform in several biomedical applications such as vaccinations, cancer-treatment, diabetes therapy and so on.

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Section: In Silico Predictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

et al. 2020

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“…For example, the colloidal solution of very small gold nanoparticles with particle sizes less than 3 nm display a light brownish transmitted color [ 15 ]. This transmitted color changes to other colors when the particle morphology changes—for example, wine red for spherical, (5–20 nm) [ 16 , 17 ], blue for nanoflowers (50–100 nm) [ 18 ], reddish-brown [ 19 ], green [ 20 ] and orange for gold nanorods of different aspect ratios or gold nanoflowers [ 20 , 21 ] and finally to black when particles are in the form of nanowire networks or twisted gold nanorods [ 22 , 23 ]. All of these morphologies have attracted great scientific attention due to their wide range of applications in various engineering and technological fields such as laser applications [ 24 ], solar cells [ 25 ], photothermal therapy [ 26 ], drug delivery [ 27 ], X-ray computed tomography [ 28 ], sensors [ 29 , 30 ], dichroic polarizer [ 31 , 32 ], display (LCD) devices [ 31 , 33 ] and paint technology [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…The diameters could be further increased to 300 nm by the seeded growth approach and by carefully adjusting the reaction conditions to inhibit any secondary nucleation [ 40 , 41 ]. More recently, a variety of other shapes such as quasi-spherical [ 18 ], nanoplates [ 42 ], nanowire network (NWN) [ 22 ], nanoflowers [ 18 ], ultrasmall gold nanoparticles [ 16 , 17 ], twisted gold nanorods [ 23 ] and colloidal gold displaying dichroic effect [ 10 , 11 , 12 , 13 , 43 ] have also been obtained by using citrate as a major reducing agent.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, the citrate-based protocol we are proposing here represents the easiest method to synthesize colloidal gold sol displaying dichroic effects without the use of any seed particles [ 13 ] or heating above room temperature [ 11 , 12 ]. Previously, we described how gold nanowire networks and gold foam could be prepared at room temperature by the citrate reduction method [ 22 ] and how morphology could be manipulated at room temperature by adding a third molecule to the reaction system [ 16 , 17 , 18 , 23 ]. In the present paper, we have further extended our work to the formation of dichroic sol displaying various transmitted colors by tuning the experimental protocol using the classical citrate method.…”

Section: Introductionmentioning

confidence: 99%

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Experimental and Theoretical Studies on Sustainable Synthesis of Gold Sol Displaying Dichroic Effect

et al. 2021

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Gold nanoparticles depending on their shape and mixtures of multiple shapes can exhibit peculiar optical properties, including the dichroic effect typical of the Lycurgus cup, which has puzzled scientists for a long time. Such optical properties have been recently exploited in several fields such as paint technology, sensors, dichroic polarizers, display (LCD) devices, laser applications, solar cells and photothermal therapy among others. In this article, we have demonstrated a simple room temperature one-pot synthesis of gold sol displaying a dichroic effect using a slow reduction protocol involving only trisodium citrate as a reducing agent. We found that the dichroic gold sol can be easily formed at room temperature by reducing gold salt by trisodium citrate below a certain critical concentration. The sol displayed an orangish-brown color in scattered/reflected light and violet/blue/indigo/purple/red/pink in transmitted light, depending on the experimental conditions. With minor changes such as the introduction of a third molecule or replacing a small amount of water in the reaction mixture with ethanol, the color of the gold sol under transmitted light changed and a variety of shades of red, pink, cobalt blue, violet, magenta and purple were obtained. The main advantage of the proposed method lies in its simplicity, which involves the identification of the right ratio of the reactants, and simple mixing of reactants at room temperature with no other requirements. TEM micrographs displayed the formation of two main types of particles viz. single crystal gold nanoplates and polycrystalline faceted polyhedron nanoparticles. The mechanism of growth of the nanoplates and faceted polyhedron particles have been described by an enhanced diffusion limited aggregation numerical scheme, where it was assumed that both trisodium citrate and the gold ions in solution undergo a stochastic Brownian motion, and that the evolution of the entire system is regulated by a principle of energy minimization. The predictions of the model matched with the experiments with a good accuracy, indicating that the initial hypothesis is correct.

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Green Nanomaterials and Their Applications

Thakur

Patel

Agrahari

2022

Encyclopedia of Green Materials

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Experimental and theoretical study of biodirected green synthesis of gold nanoflowers

Cited by 18 publications

References 45 publications

Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

Experimental and Theoretical Studies on Sustainable Synthesis of Gold Sol Displaying Dichroic Effect

Green Nanomaterials and Their Applications

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