Experiences in One Hundred Thirty-Seven Patients Treated with Oral Griseofulvin

Goldfarb, Norman

doi:10.1001/archderm.1960.03730050215038

Cited by 26 publications

(8 citation statements)

References 3 publications

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“…Griseofulvin has been implicated in several skin eruptions (Blank 1982;Goldfarb & Salzberger 1960). A prominent skin manifestation is a photodermatitis (Chang 1965;Kojima et al 1988).…”

Section: Dermatological Effectsmentioning

confidence: 99%

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

1992

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Systemic administration of antifungal agents for invasive mycoses has dramatically increased over the past 10 years in many fields of medicine. The increase has been due both to an increasing immune compromised population and to potent antibacterial agents which allow these fungi to invade tissue. It is apparent that our understanding of the use of both the old and new antifungal agents has significantly increased in the last few years. In this review, we attempt to document our extensive knowledge of the adverse effects of the polyenes, flucytosine, griseofulvin and azoles when given systemically for treatment. Interwoven in this documentation of the adverse reactions to these agents is the attempt to help clinicians potentially avoid some of these adverse effects and if they do occur, to be able to identify and successfully manage them.

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“…Griseofulvin has been implicated in several skin eruptions (Blank 1982;Goldfarb & Salzberger 1960). A prominent skin manifestation is a photodermatitis (Chang 1965;Kojima et al 1988).…”

Section: Dermatological Effectsmentioning

confidence: 99%

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

1992

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“…Reports partially or completely excluded from the meta-analysis can be found in Refs. [41,[44][45][46][48][49][50][51][52][53][54][55][56][57][58][59][60].…”

Section: Introductionmentioning

confidence: 99%

The new oral antifungal agents for onychomycosis of the toenails

Gupta

Shear

1999

Acad Dermatol Venereol

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Itraconazole, terbinafine and fluconazole have been used approximately 100 million times to treat superficial mycoses. These agents are more effective than the traditional antimycotics for the treatment of pedal onychomycosis; furthermore, the new agents have a broader spectrum of action than griseofulvin. In general, itraconazole, terbinafine and fluconazole have a favorable adverse-effects profile with drug interactions that are usually predictable and manageable. The new oral antifungal agents have a high benefit-to-risk ratio when used to treat toenail onychomycosis.

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“…Adverse photosensitization induced by griseofulvin (GF) is well known and has been documented (1)(2)(3)(4). However, only a few cases have been reported with full particulars clinically, histologically, and photobiologically.…”

Section: Introductionmentioning

confidence: 99%

Griseofulvin‐induced Photodermatitis

Kojima

Hasegawa

Ishida

et al. 1988

The Journal of Dermatology

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Six Japanese cases of griseofulvin (GF)‐induced photodermatitis were reported. All of the patients had received GF from 4 days to 4 months as treatment for tinea unguium. Clinical features were basically eczematous, but differed somewhat case by case. Patient 2 showed pigmentation and depigmentation and patient 5 showed pellagra‐like eruptions. From the clinical view, we could not differentiate precisely between phototoxic and photoallergic reactions. The difference may also depend on response severity, duration of skin eruption, or skin color. Blood and urine porphyrins were within normal ranges. An action spectrum study revealed that UVA was responsible for eliciting a photosensitivity reaction. Patch and photopatch tests were performed on all 6 patients. The results of the photopatch tests were positive for 3 patients and negative for the other 3. The degrees of reaction to photopatch tests differed so widely that it was difficult to determine suitable conditions for UVA intensity or GF concentrations for photopatch testing. Moreover, half of the patients showed negative photopatch tests. Although there is merit in the use of photopatch tests for studying the causes of systemically administered drug‐induced photodermatitis, there may also be limits to their usage. When performed carefully, drug readministration is a more reliable method. From the results of positive photopatch tests, photocross reactions between GF and penicillin, persistent light reactions and distant flare up phenomena, we concluded that in some of our cases, reactions were photoallergic. Histological findings showed non‐specific inflammatory changes. Direct immunofluorescence studies showed that immunoglobulin and complement were deposited at papillary perivascular areas and the dermo‐epidermal junction.

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Experiences in One Hundred Thirty-Seven Patients Treated with Oral Griseofulvin

Cited by 26 publications

References 3 publications

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

The new oral antifungal agents for onychomycosis of the toenails

Griseofulvin‐induced Photodermatitis

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