Experience of splenectomy and cholecystectomy in children with chronic haemolytic anaemia

Cholelithiasis in Saudi Patients with Sickle Cell Anemia

“…Due to the improved clinical care of patients with sickle cell anemia, there is an increase in survival of these patients to ages known to have a higher incidence of gallstones or to survive so that stones become symptomatic. As with others [14][15][16], we feel that removal of stones on an elective surgical basis can first eliminate the possibility of future development of gallstone related complications and simplify their management in subsequent attacks of abdominal crisis.…”

“…There is now general agreement about cholecystectomy in symptomatic gallstones in patients with sickle cell anemia, but opinions differ regarding the advisability of cholecystectomy in asymptomatic patients. This is based on the previous reports [12,13] of high incidence of complications in patients with sickle cell anemia, but with a better understanding of the disease, careful preoperative management, the morbidity of cholecystectomy in patients with sickle cell anemia has been decreased [14][15][16][17]. As a result of these encouraging results, an increasing number of surgeons are advocating cholecystectomy for asymptomatic gallstone patients.…”

A case report of spherocytosis presenting with choledocholithiasis in early childhood and a review of the literature

“…12 Pappis et al reported 419 children with chronic haemolytic anaemia, 53 of whom developed choledocholithiasis; the youngest was 6.5 years old. 2 Debray et al reported neonatal haemolysis, rather than red cell membrane defect, in two patients as a predisposing factor for choledocholithiasis in infancy. 1 Choledocholithiasis due to haemolysis is of the black pigment stones type.…”

Management of Gallstones in the Pediatric Patient

“…Patients with thalassemia or HS and co-inherited Gilbert's syndrome have a higher incidence of cholelithiasis, suggesting that children with concomitant disease should have early gallbladder ultrasonography and closer follow-up [ 79 , 80 ]. As in patients with SCD, concomitant cholecystectomy with splenectomy has been successfully performed in patients with beta-thalassemia [ 81 ]. Feretis et al [ 82 ] suggest that patients with betathalassemia undergo simultaneous splenectomy and prophylactic cholecystectomy; however, this recommendation has not been further studied.…”