2013
DOI: 10.1038/ni.2647
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Abstract: The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-α (IFN-α) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-α-treated LNPCs were rich in molecules with antiviral activity. Moreover, exosomes from LNPCs were internalized by hepatocytes, which mediated the intercellu… Show more

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Cited by 453 publications
(435 citation statements)
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“…We conclude that the restricted antiviral protein signature in EBV-driven LCL is not selectively conferred to exosomes. This finding is distinct from exosomes released by cells that are exposed to IFN-α, which carry an elaborate antiviral proteome (28).…”
Section: Latent Ebv-infected Exosomes Do Not Display An Antiviral Promentioning
confidence: 88%
See 1 more Smart Citation
“…We conclude that the restricted antiviral protein signature in EBV-driven LCL is not selectively conferred to exosomes. This finding is distinct from exosomes released by cells that are exposed to IFN-α, which carry an elaborate antiviral proteome (28).…”
Section: Latent Ebv-infected Exosomes Do Not Display An Antiviral Promentioning
confidence: 88%
“…Recent studies in IFN-exposed DCs suggested that exosomes incorporate and transfer antiviral proteins (28). To investigate the possibility that latent EBV-infected cells release antiviral proteins via exosomes, we performed label-free mass spectrometric proteomics on LCLs whose proliferation is EBVdriven and, among others, CD40L-stimulated uninfected B cells with identical genetic background as a physiologically relevant control (Dataset S1).…”
Section: Latent Ebv-infected Exosomes Do Not Display An Antiviral Promentioning
confidence: 99%
“…Interferon-␣-stimulated cells induce exosomes that can carry antiviral molecules (46). Increase of VLP release in Rab27a KD cells might be related to inhibition of release of exosomes carrying antiviral molecules.…”
Section: Discussionmentioning
confidence: 99%
“…Nowadays, exosomes are recognized as the natural carriers of many signal molecules that mediate cell-cell communication and exert critical influences on tumorigenesis, 17 autoimmune diseases, 18 infections, 19,20 and cardiovascular diseases. 21,22 The biogenesis of exosomes starts with the formation of late endosomes, also called multivesicular bodies (MVBs), which originate from reverse invagination of the cellular plasma membrane.…”
Section: Exosomes' Biogenesis Biodistribution and Transportationmentioning
confidence: 99%