Exosomes in the pathogenesis and treatment of ocular diseases

Zhang, Zhihan; Liang, Xing; Zhou, Jing; Meng, Meijun; Gao, Ya; Yi, Guoguo; Fu, Min

doi:10.1016/j.exer.2021.108626

Cited by 10 publications

(8 citation statements)

References 150 publications

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“…Besides, CSSC-derived EVs decrease stromal scarring and regenerate normal corneal collagen ( 91 , 92 ). Also, adipose-derived MSC-derived Exos enhance corneal stromal cell proliferation, inhibit apoptosis, and are involved in extracellular matrix remodeling ( 87 , 93 ).…”

Section: Inflammation-related Diseasesmentioning

confidence: 99%

“…Additionally, different studies showed that exosomes mediated adaptive immune responses and participated in corneal allograft rejection ( 100 ). MSC-derived Exos prolong corneal graft survival by prohibiting the Th1 signaling pathway, reducing chemokines like CXCL9, CXCL10, and CXCL11, and upregulating regulatory T cells ( 87 , 101 ). Therefore, MSC-derived Exos might be potential therapeutic agents for refractory graft-versus-host disease and corneal transplant rejection ( 102 , 103 ).…”

Section: Inflammation-related Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Habibi

Zarei-Behjani²,

Falamarzi³

et al. 2023

Front. Immunol.

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Extracellular vesicles include exosomes, microvesicles, and apoptotic bodies. Their cargos contain a diverse variety of lipids, proteins, and nucleic acids that are involved in both normal physiology and pathology of the ocular system. Thus, studying extracellular vesicles may lead to a more comprehensive understanding of the pathogenesis, diagnosis, and even potential treatments for various diseases. The roles of extracellular vesicles in inflammatory eye disorders have been widely investigated in recent years. The term “inflammatory eye diseases” refers to a variety of eye conditions such as inflammation-related diseases, degenerative conditions with remarkable inflammatory components, neuropathy, and tumors. This study presents an overview of extracellular vesicles’ and exosomes’ pathogenic, diagnostic, and therapeutic values in inflammatory eye diseases, as well as existing and potential challenges.

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Section: Inflammation-related Diseasesmentioning

confidence: 99%

Section: Inflammation-related Diseasesmentioning

confidence: 99%

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Habibi

Zarei-Behjani²,

Falamarzi³

et al. 2023

Front. Immunol.

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show abstract

“…Recently, this peculiar activity of theirs has gained the attention of researchers. Indeed, MSCs secrete exosomes by triggering paracrine signaling on other cells [ 72 , 94 ]. Concisely, cells release these vesicles composed of different intracellular compounds such as nucleic acids, proteins and lipids, each one providing a specific biological function depending on the recipient cell [ 95 ].…”

Section: Subcellular Therapiesmentioning

confidence: 99%

Corneal Epithelial Regeneration: Old and New Perspectives

Nuzzi

Giuffrida

Luccarelli

et al. 2022

IJMS

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Corneal blindness is the fifth leading cause of blindness worldwide, and therapeutic options are still often limited to corneal transplantation. The corneal epithelium has a strong barrier function, and regeneration is highly dependent on limbal stem cell proliferation and basement membrane remodeling. As a result of the lack of corneal donor tissues, regenerative medicine for corneal diseases affecting the epithelium is an area with quite advanced basic and clinical research. Surgery still plays a prominent role in the treatment of epithelial diseases; indeed, innovative surgical techniques have been developed to transplant corneal and non-corneal stem cells onto diseased corneas for epithelial regeneration applications. The main goal of applying regenerative medicine to clinical practice is to restore function by providing viable cells based on the use of a novel therapeutic approach to generate biological substitutes and improve tissue functions. Interest in corneal epithelium rehabilitation medicine is rapidly growing, given the exposure of the corneal outer layers to external insults. Here, we performed a review of basic, clinical and surgical research reports on regenerative medicine for corneal epithelial disorders, classifying therapeutic approaches according to their macro- or microscopic target, i.e., into cellular or subcellular therapies, respectively.

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“…Current evidence indicates that sEVs can regulate long-distance organs or neighboring cells and modulate tumor progression and metastasis [10][11][12][13][14]. Moreover, sEVs have been pointed out as potential therapeutic molecules and might be key for early diagnosis on different eye-related disorders [15,16].…”

Section: Introductionmentioning

confidence: 99%

Oxidative-Induced Angiogenesis Is Modulated by Small Extracellular Vesicle miR-302a-3p Cargo in Retinal Pigment Epithelium Cells

et al. 2022

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Extracellular vesicles are released from cells under diverse conditions. Widely studied in cancer, they are associated with different diseases playing major roles. Recent reports indicate that oxidative damage promotes the release of small extracellular vesicle (sEVs) from the retinal pigment epithelium (RPE), with an angiogenic outcome and changes in micro-RNA (miRNA) levels. The aim of this study was to determine the role of the miRNA miR-302a-3p, included within RPE-released sEVs, as an angiogenic regulator in cultures of endothelial cells (HUVEC). ARPE-19 cell cultures, treated with H2O2 to cause an oxidative insult, were transfected with a miR-302a-3p mimic. Later, sEVs from the medium were isolated and added into HUVEC or ARPE-19 cultures. sEVs from ARPE-19 cells under oxidative damage presented a decrease of miR-302a-3p levels and exhibited proangiogenic properties. In contrast, sEVs from miR-302a-3p-mimic transfected cells resulted in control angiogenic levels. The results herein indicate that miR-302a-3p contained in sEVs can modify VEGFA mRNA expression levels as part of its antiangiogenic features.

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Exosomes in the pathogenesis and treatment of ocular diseases

Cited by 10 publications

References 150 publications

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Corneal Epithelial Regeneration: Old and New Perspectives

Oxidative-Induced Angiogenesis Is Modulated by Small Extracellular Vesicle miR-302a-3p Cargo in Retinal Pigment Epithelium Cells

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