Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy

Zhang, Zhiqiang; Chen, Lei; Chen, Xueheng; Qin, Yiran; Tian, Chao; Dai, Xuening; Meng, Runqi; Zhong, Yuanyuan; Liang, Wenyan; Cheng, Shen; Zhang, Jinguo; Zhang, Bin; Wei, Xiqing

doi:10.1016/j.bbrc.2022.10.001

Cited by 12 publications

(6 citation statements)

References 46 publications

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“…The functions of cardiomyocyte autophagy may have conflicting conclusion in DCM [ 137 – 140 ]. The exosomes derived from hUCMSCs were reported to improve cardiac insufficiency and ventricular remodeling, through suppressing excessive autophagy mediated by the AMPK-ULK1 pathway in DCM rats [ 141 ]. These findings offer empirical support for the therapeutic efficacy of MSCs-exosomes in the management of DCM (Fig.…”

Section: Mscs Derived Exosomes and Diabetic Complicationsmentioning

confidence: 99%

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Jiao,

Chen,

Tang

et al. 2024

Cell Death Dis

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Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.

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Section: Mscs Derived Exosomes and Diabetic Complicationsmentioning

confidence: 99%

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Jiao,

Chen,

Tang

et al. 2024

Cell Death Dis

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“…To illustrate the intricate nature of the effects of SCEVs in complex cardiovascular pathologies affecting the myocardium and the vasculature alike, systemic administration of MSC-Exo in a doxorubicin-induced dilated cardiomyopathy mouse model has been shown to not only improve cardiac function and reduce cardiomyocyte apoptosis but to decrease the inflammatory cell infiltration as well via modulation of macrophage polarization by the activation of the JAK2/STAT6 pathway [ 152 ]. Moreover, it has been observed that human umbilical cord mesenchymal stromal cell-derived EVs (UC-MSC-EVs) reduce autophagy-related protein levels in cardiomyocytes in a type-2 diabetic cardiomyopathy model by inhibition of the AMPK-ULK1 pathway [ 153 ]. These data indicate that SCEVs have inherent flexibility to exert comparable beneficial effects in cardiovascular pathologies with a distinct underlying pathomechanism.…”

Section: Role Of Stem Cell-derived Extracellular Vesicles In Heart Di...mentioning

confidence: 99%

Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases

McDonald,

Mohak,

Fabian

2024

Pharmaceutics

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Cardiovascular disease constitutes a noteworthy public health challenge characterized by a pronounced incidence, frequency, and mortality rate, particularly impacting specific demographic groups, and imposing a substantial burden on the healthcare infrastructure. Certain risk factors, such as age, gender, and smoking, contribute to the prevalence of fatal cardiovascular disease, highlighting the need for targeted interventions. Current challenges in clinical practice involve medication complexities, the lack of a systematic decision-making approach, and prevalent drug therapy problems. Stem cell-derived extracellular vesicles stand as versatile entities with a unique molecular fingerprint, holding significant therapeutic potential across a spectrum of applications, particularly in the realm of cardio-protection. Their lipid, protein, and nucleic acid compositions, coupled with their multifaceted functions, underscore their role as promising mediators in regenerative medicine and pave the way for further exploration of their intricate contributions to cellular physiology and pathology. Here, we overview our current understanding of the possible role of stem cell-derived extracellular vesicles in the clinical management of human cardiovascular pathologies.

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“…Currently, hUMSCs are used to treat more than a dozen diseases [ 12 ], including endocrine and metabolic diseases (including but not limited to type 1 diabetes [ 31 ], type 2 diabetes [ 32 ], diabetic foot [ 33 ], diabetic nephropathy [ 34 ], diabetic cardiomyopathy [ 33 , 35 ] diabetic retinopathy [ 36 ] and other complications), liver diseases (including but not limited to hepatitis [ 37 ], fatty liver [ 38 ], cirrhosis [ 39 , 40 ], and liver cancer [ 41 ]), autoimmune diseases (including but not limited to systemic lupus erythematosus [ 42 ] and rheumatoid arthritis [ 43 ]), CNS diseases (including but not limited to brain injury [ 44 ], SCI [ 45 ], cerebrovascular disease [ 46 ], and Alzheimer's disease [ 47 ]), cardiovascular system diseases (including but not limited to myocardial infarction [ 48 ], heart failure [ 49 ], myocardial ischaemia [ 50 ], and myocarditis [ 51 ]), respiratory diseases (including but not limited to acute lung injury [ 52 ], bronchial asthma [ 53 ], and chronic obstructive pulmonary disease [ 54 ]), infectious diseases (including but not limited to coronavirus [ 55 ], influenza virus [ 56 ], HIV [ 57 ] and other viral infections), graft-versus-host disease [ 58 ] and osteoporosis [ 59 ], etc . (Fig.…”

Section: Therapeutic Role Of Humscsmentioning

confidence: 99%

Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury

Shen,

Lu,

Cai

et al. 2024

Stem Cell Res Ther

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Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However, due to the complexity of the central nervous system (CNS), achieving successful clinical translation remains a significant challenge. Human umbilical cord mesenchymal stem cells (hUMSCs) possess distinct advantages, such as easy collection, lack of ethical concerns, high self-renewal ability, multilineage differentiation potential, and immunomodulatory properties. hUMSCs are promising for regenerating the injured spinal cord to a significant extent. At the same time, for advancing SCI treatment, the appropriate benefit and risk evaluation methods play a pivotal role in determining the clinical applicability of treatment plans. Hence, this study discusses the advantages and risks of hUMSCs in SCI treatment across four dimensions—comprehensive evaluation of motor and sensory function, imaging, electrophysiology, and autonomic nervous system (ANS) function—aiming to improve the rationality of relevant clinical research and the feasibility of clinical translation.

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Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy

Cited by 12 publications

References 46 publications

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases

Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury

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