Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis

Wei, Jizhen; Song, Yeqing; Du, Zhi‐Hao; Yu, Feiyan; Zhang, Yimei; Jiang, Nan; Ge, Xuejun

doi:10.1007/s10735-020-09896-3

Cited by 54 publications

(86 citation statements)

References 46 publications

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“…[43] This osteogenesis promotion effects has been proved in a periodontitis caused bone loss model in mouse. [43] The osteogenesis effect of GMSCs derived exosomes was also confirmed in animal experiments model. GMSCs-Exos effectively promoted GMSCs osteogenic differentiation in combination with a 3D PLA porous scaffold, such as effectively promoted calcium deposition and the high expression of osteogenic markers: RUNX2, VEGFA, OPN and COL1A1 [44].…”

Section: Osteogenesis Effectsmentioning

confidence: 89%

“…Besides, the SHEDs-Exos can promoted BMSCs osteogenesis and inhibited adipogenesis, manifested as high expression of RUNX2 and p-Smad5, decrease expression of PPARγ. [ 43 ] This osteogenesis promotion effects has been proved in a periodontitis caused bone loss model in mouse. [ 43 ]…”

Section: Biological Function Of Exosomes Derived From Oral Tissue Stementioning

confidence: 99%

“…[ 43 ] This osteogenesis promotion effects has been proved in a periodontitis caused bone loss model in mouse. [ 43 ]…”

Section: Biological Function Of Exosomes Derived From Oral Tissue Stementioning

confidence: 99%

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Exosomes from oral tissue stem cells: biological effects and applications

et al. 2020

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As natural nanoparticles, exosomes are a type of extracellular vesicles that are enclosed by a lipid bilayer and contain various cargos, including miRNA, mRNA, DNA and proteins. Exosomes have rapidly gained attention as a highly promising cell-free therapy. Because the cargo of exosomes changes with the changes in parent cells and status, exosomes from different types of cells may exhibit different biological effects. Considering the particularity of oral tissue stem cells, their exosomes were isolated and used to examine their related biological functions and the possibility of replacing stem cells. A variety of exosomes of oral tissue stem cells were studied, and the results revealed many special biological characteristics of these exosomes and their parent cells, especially immunomodulation, osteogenesis, odontogenesis, neuroprotection, nerve regeneration, wound healing, skin regeneration and vascularization. The oral tissue stem cell exosomes may be loaded with drugs or genes and act as tools for tumor treatment. The relevant results showed that exosomes from oral tissue stem cells were potent therapeutic tools. The present review focuses on the biological function and application of oral tissue stem cell-derived exosomes.

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Section: Osteogenesis Effectsmentioning

confidence: 89%

Section: Biological Function Of Exosomes Derived From Oral Tissue Stementioning

confidence: 99%

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Exosomes from oral tissue stem cells: biological effects and applications

et al. 2020

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“…They are derived from endosomes, which mature into multivesicular bodies and then fuse with the plasma membrane to release sEV into the extracellular space (Figure 1). They have a size ranging from 30 to 150 nm (depending on the literature 13,17,19,21‐23 ) and can be easily transported through biological fluids. They are released from almost all cell types and can be found in most body fluids, including blood, saliva, urine, and breast milk 23,24 .…”

Section: Sev a Type Of Extracellular Vesiclesmentioning

confidence: 99%

“…They have a size ranging from 30 to 150 nm (depending on the literature 13,17,19,21‐23 ) and can be easily transported through biological fluids. They are released from almost all cell types and can be found in most body fluids, including blood, saliva, urine, and breast milk 23,24 . They are particles with a bilayer membrane composed of various lipids and proteins and containing essential biomolecules derived from their parent cells 25 .…”

Section: Sev a Type Of Extracellular Vesiclesmentioning

confidence: 99%

Mesenchymal stem cell‐derived small extracellular vesicles as cell‐free therapy: Perspectives in periodontal regeneration

Novello

Pellen‐Mussi

Jeanne

2021

J of Periodontal Research

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Mesenchymal stem cells (MSC) are involved in the regeneration of the different missing or compromised periodontal tissues. MSC‐derived small extracellular vesicles (sEV) have recently been explored as a favorable substitution for stem cell therapy, as they are capable of producing therapeutic effects comparable to those of their parent cells, with advantages over cell therapy. The aim of this review is to evaluate the use of mesenchymal stem cells (MSC)‐derived sEV as cell‐free therapy in periodontal regeneration. A review of the scientific literature on sEV and their use in periodontal regeneration was performed. The main characteristics of sEV are described, and their mechanisms of action and potential biological effects in periodontal regeneration are studied. A summary of existing preclinical studies conducted in animals is performed. The results indicate that sEV derived from MSC are emerging as a promising new therapeutic tool in the field of periodontal regeneration and may become an ideal therapeutic option. In this review, we have summarized recent advances in this regard in order to better understand this newly emerging treatment. First results in vivo are promising and show a favorable potential for cell‐free therapy in periodontal regeneration.

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