Exosome Releasing HSPD1 Assists HNF1A in Regulating the Invasion Ability and Radiosensitivity of Esophageal Squamous Cell Carcinoma Cells via Activating EMT
Abstract:Background: Concurrent chemoradiotherapy is the standard scheme for locally advanced non-surgical esophageal squamous cell carcinoma (ESCC). But there are frequently different results due to tumor heterogeneity. HNF1A and HSPD1 have been shown to be associated with the invasion, proliferation, apoptosis, and chemical resistance in multiple cancers. The aim of this study was to investigate the effects of HNF1A and HSPD1 on invasion and radiosensitivity of ESCC.Methods: HNF1A was overexpressed by lentivirus tran… Show more
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