2020
DOI: 10.1186/s13046-019-1507-2
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Abstract: Background: Cancer-associated fibroblasts (CAFs) have been intensively studied in recent studies with aims of finding more concrete evidence on their mechanism of involvement in tumor progression, which is currently unknown. CAFs can secrete exosomes which are loaded with proteins, lipids and RNAs, all of which affect tumor microenvironment. The present study identified microRNA-93-5p (miR-93-5p) as a novel exosomal cargo responsible for the pro-tumorigenic effects of CAFs on colorectal cancer (CRC). Methods: … Show more

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Cited by 87 publications
(63 citation statements)
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References 29 publications
(38 reference statements)
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“…Among the many constituents of the TME, CAFs may contribute significantly to cancer pathogenesis and response(s) to therapy. Identifying CAFs and eradicating them during treatment, particularly when they may exist at the margin of the radiotherapy PTV, could improve efficacy of the treatments [ 79 , 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among the many constituents of the TME, CAFs may contribute significantly to cancer pathogenesis and response(s) to therapy. Identifying CAFs and eradicating them during treatment, particularly when they may exist at the margin of the radiotherapy PTV, could improve efficacy of the treatments [ 79 , 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…6 ). 367 369 In addition, the formation of a hypoxic microenvironment and the EMT driven by CAFs can also confer radioresistance onto cancer cells. 370 373 In particular, we concluded that CSCs played an important role in the poor efficacy of RT and that CSCs survived more easily due to their potential innate radioresistance, which was partially induced by CAFs.…”
Section: Therapeutic Resistance Caused By Cafsmentioning
confidence: 99%
“…Importantly, this effect was reversible with the addition of anti-FGF-1 or anti-FGF3 treatments. Additional CAF effects in colorectal cancers include maintenance of cancer cell stemness, as described by Liu et al when CAF-conditioned media was observed to promote clonogenicity of colorectal cancer cells, which in turn conferred radioresistance through CAF-derived exosomes [ 91 , 92 ]. When exploring esophageal cancers, Zhao et al demonstrated that CAFs expressing α-SMA enhanced progression of esophageal squamous cell carcinomas by promoting Shh expression, and notably this effect was partially reversible in vitro and in vivo by using cyclopamine to inhibit the Hedgehog signaling pathway [ 50 ].…”
Section: Caf Promotion Of Tumor Growth and Maintenance Of Stemnessmentioning
confidence: 99%