Exophthalmic Goître Combined With Myasthenia Gravis

Rennie, George E.

doi:10.5694/j.1326-5377.1919.tb30632.x

Cited by 9 publications

(10 citation statements)

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“…The association of Graves disease with myasthenia gravis was first described in 1908 [13]. Since then, this association has often been reported [14–17].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Lakhal¹,

Blel

Fysekidis

et al. 2008

Anaesthesia

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Summary Autoimmune thyroxicosis and myasthenia gravis are often associated. In both diseases, clinical features may include neuromuscular weakness, making their distinction challenging. We report a patient with known Graves disease who presented with generalised fatigue, initially attributed solely to thyrotoxicosis, and who experienced severe respiratory failure linked to associated myasthenia gravis that was unmasked by medication used in the perioperative management of his thyroxicosis. Anaesthetists should always consider myasthenia gravis in cases of hyperthyroidism presenting with neuromuscular features.

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“…The association of Graves disease with myasthenia gravis was first described in 1908 [13]. Since then, this association has often been reported [14–17].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Lakhal¹,

Blel

Fysekidis

et al. 2008

Anaesthesia

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“…The hypothesis that they are separate diseases is supported by several features, such as the greater frequency of thymic disease and serum AchRAb in GMG compared to OMG (6 -8). The coexistence of other autoimmune diseases in MG is well recognized (1,10,11,21,22), including the association with AITD (8, 10 -20). However, the influence of AITD on the clinical expression of MG has not been defined.…”

Section: Discussionmentioning

confidence: 99%

Mild Clinical Expression of Myasthenia Gravis Associated with Autoimmune Thyroid Diseases¹

Marinò

Ricciardi

Pinchera³

et al. 1997

The Journal of Clinical Endocrinology & Metabolism

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Myasthenia gravis (MG) may occur in association with autoimmune thyroid diseases (AITD). The aim of this study was to evaluate the features of MG associated with AITD compared to those of MG without AITD. A total of 129 MG patients (34 men and 95 women; age range, 11-81 yr) were subdivided into: group A, 56 MG patients with AITD [25 with autoimmune thyroiditis and 31 with Graves' disease (GD)]; group B, 21 MG patients with nonautoimmune thyroid diseases; and group C, 52 MG patients without thyroid disease. The severity of MG was ranked according to the Osserman score. Laboratory evaluation included assays for antithyroid and antiacetylcholine receptor (AchRAb) antibodies. Ocular MG (Osserman's class 1) was more frequent in group A (41.0%) than in group B (14.2%; P < 0.03) or C (21.4%; P < 0.03). Severe generalized MG (classes > or = 2B) was more frequent in groups B (57.1%; P < 0.03) and C (51.9%; P < 0.02) than in group A (28.5%). GD patients with clinical evidence of ophthalmopathy had a higher frequency (P = 0.05) of ocular MG (57.8%) than GD patients without clinical ophthalmopathy (16.6%). Thymic disease was less frequent in group A (26.7%) than in group B (71.4%; P = 0.001) or C (59.7%; P = 0.001). The prevalence of thymic hyperplasia was 17.8%, 38.0%, and 40.3% in groups A, B, and C, respectively; the prevalence of thymoma was 8.9%, 33.4%, and 19.4%. When only patients with generalized MG were considered, thymic disease was less frequent (P < 0.02) in group A (40.6%) than in the remaining groups (69.4%). AchRAb was more frequent in groups B (57.1%) and C (57.6%; P < 0.03) than in group A (35.7%). In conclusion, MG associated with AITD has a mild clinical expression, with preferential ocular involvement and lower frequency of thymic disease and AchRAb. This supports the hypothesis that ocular and generalized MG are separate diseases with different spectra of associated diseases. Nonautoimmune thyroid diseases have no influence on the features of MG. The association of ocular MG and AITD might be due to a common autoimmune mechanism and/or a peculiar genetic background.

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“…Intramuscular prostigmine methylsulfate was administered in the immediate postopera¬ tive period and continued for 1 week, when a course of pyridostigmine bromide therapy was again instituted.…”

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confidence: 99%

Myasthenic Syndrome with Associated Neuropathy

Steidl¹,

Oswald²,

Kottke³

1962

Arch Neurol

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Exophthalmic Goître Combined With Myasthenia Gravis

Cited by 9 publications

References 0 publications

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Mild Clinical Expression of Myasthenia Gravis Associated with Autoimmune Thyroid Diseases¹

Myasthenic Syndrome with Associated Neuropathy

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Exophthalmic Goître Combined With Myasthenia Gravis

Cited by 9 publications

References 0 publications

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter

Mild Clinical Expression of Myasthenia Gravis Associated with Autoimmune Thyroid Diseases1

Myasthenic Syndrome with Associated Neuropathy

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Mild Clinical Expression of Myasthenia Gravis Associated with Autoimmune Thyroid Diseases¹