Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Pajk, Melitta; Cselkó, Alexandra; Varga, Csaba; Pósa, Anikó; Tokodi, Margaréta; Boldogh, István; Goto, Sataro; Radák, Zsolt

doi:10.1007/s10522-017-9705-9

Cited by 17 publications

(12 citation statements)

References 41 publications

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“…This suggests that the response to enhanced NAD+ metabolism is tissue specific. Similar to the above experiments, supplementation with NAM for 5 weeks enhanced SIRT1 activity in young and aged rats [ 64 ]. However, combining exercise training with NAM supplementation decreased SIRT1 levels [ 64 ].…”

Section: Nad+ and Aging Musclesupporting

confidence: 63%

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A need for NAD+ in muscle development, homeostasis, and aging

Goody

Henry

2018

Skeletal Muscle

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Skeletal muscle enables posture, breathing, and locomotion. Skeletal muscle also impacts systemic processes such as metabolism, thermoregulation, and immunity. Skeletal muscle is energetically expensive and is a major consumer of glucose and fatty acids. Metabolism of fatty acids and glucose requires NAD+ function as a hydrogen/electron transfer molecule. Therefore, NAD+ plays a vital role in energy production. In addition, NAD+ also functions as a cosubstrate for post-translational modifications such as deacetylation and ADP-ribosylation. Therefore, NAD+ levels influence a myriad of cellular processes including mitochondrial biogenesis, transcription, and organization of the extracellular matrix. Clearly, NAD+ is a major player in skeletal muscle development, regeneration, aging, and disease. The vast majority of studies indicate that lower NAD+ levels are deleterious for muscle health and higher NAD+ levels augment muscle health. However, the downstream mechanisms of NAD+ function throughout different cellular compartments are not well understood. The purpose of this review is to highlight recent studies investigating NAD+ function in muscle development, homeostasis, disease, and regeneration. Emerging research areas include elucidating roles for NAD+ in muscle lysosome function and calcium mobilization, mechanisms controlling fluctuations in NAD+ levels during muscle development and regeneration, and interactions between targets of NAD+ signaling (especially mitochondria and the extracellular matrix). This knowledge should facilitate identification of more precise pharmacological and activity-based interventions to raise NAD+ levels in skeletal muscle, thereby promoting human health and function in normal and disease states.

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Section: Nad+ and Aging Musclesupporting

confidence: 63%

“…Similar to the above experiments, supplementation with NAM for 5 weeks enhanced SIRT1 activity in young and aged rats [ 64 ]. However, combining exercise training with NAM supplementation decreased SIRT1 levels [ 64 ]. NAM can inhibit SIRT1 and PARP-1 under stress conditions to preserve NAD+ levels.…”

Section: Nad+ and Aging Musclesupporting

confidence: 63%

A need for NAD+ in muscle development, homeostasis, and aging

Goody

Henry

2018

Skeletal Muscle

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“…During the process of aging and in several disease models, the demand on the NAD + pool far exceeds its availability [4–6]. While nicotinic acid [7] and nicotinamide [8–9] are long-standing vitamin B3 supplements known to restore depleted NAD + levels [10–12], it was only recently that NR + and its phosphorylated form, nicotinamide mononucleotide (NMN), have become orally available as nutraceutical precursors of NAD + [13–16]. This followed the identification of the biosynthetic pathways which use these ribosylated building blocks for the efficient synthesis of NAD + in humans.…”

Section: Introductionmentioning

confidence: 99%

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

Makarov

Migaud

2019

Beilstein J. Org. Chem.

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The β-anomeric form of nicotinamide riboside (NR+) is a precursor for nicotinamide adenine dinucleotide (NAD+), a redox cofactor playing a critical role in cell metabolism. Recently, it has been demonstrated that its chloride salt (NR+Cl−) has beneficial effects, and now NR+Cl− is available as a dietary supplement. Syntheses and studies of analogues and derivatives of NR+ are of high importance to unravel the role of NR+ in biochemical processes in living cells and to elaborate the next generation of NR+ derivatives and conjugates with the view of developing novel drug and food supplement candidates. This review provides an overview of the synthetic approaches, the chemical properties, and the structural and functional modifications which have been undertaken on the nicotinoyl riboside scaffold.

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“…NA and NAM are components of coenzyme I (NAD+) and coenzyme II (NADP+) in the human body, which act as electron carriers or hydrogen transporters in biological redox and are involved in lipid and sugar metabolism, energy metabolism, oxidative stress, and inflammation regulation [42,43]. Exogenous supplementation of NAM can improve NAD+ utilization, delay skeletal muscle aging, and facilitate cellular metabolism [44]. Increasing NAD+ levels promote sirtuin 1 (SIRT1) activity leading to deacetylation, which activates the peroxisome proliferator-activated receptor γ -coactivator 1α (PGC-1 α ) [45].…”

Section: Analysis Of Niacin and Nicotinamide Metabolismmentioning

confidence: 99%

Mechanism of the Effect of High-Intensity Training on Urinary Metabolism in Female Water Polo Players Based on UHPLC-MS Non-Targeted Metabolomics Technique

Wang¹,

Chen²,

Li³

et al. 2021

Preprint

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Objective: To study the changes in urine metabolism in female water polo players before and after high-intensity training by using ultra-high performance liquid chromatography-mass spectrometry, and to explore the biometabolic characteristics of urine after training and competition. Methods: Twelve young female water polo players (except goalkeepers) from Shanxi Province were selected. A 4-week formal training was started after one week of acclimatization according to experimental requirements. Urine samples (5 ml) were collected before formal training, early morning after 4 weeks of training, and immediately after 4 weeks of training matches, and labeled as T1, T2, and T3, respectively. The samples were tested by LC-MS after pre-treatment. XCMS, SIMCA-P 14.1, and SPSS16.0 were used to process the data and identify differential metabolites. Results: On comparing the immediate post-competition period with the pre-training period (T3 vs T1), 24 differential metabolites involved in 16 metabolic pathways were identified, among which niacin and niacinamide metabolism and purine metabolism were potential post-competition urinary metabolic pathways in the untrained state of the athletes. On comparing the immediate post-competition period with the post-training period (T3 vs T2), 10 metabolites involved in 3 metabolic pathways were identified, among which niacin and niacinamide metabolism was a potential target urinary metabolic pathway for the athletes after training. Niacinamide, 1-methylnicotinamide, 2-pyridone, L-Gln, AMP, and Hx were involved in two metabolic pathways before and after the training. Conclusion: Differential changes in urine after water polo games are due changes in the metabolic pathways of niacin and niacinamide.

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Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Cited by 17 publications

References 41 publications

A need for NAD+ in muscle development, homeostasis, and aging

A need for NAD+ in muscle development, homeostasis, and aging

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

Mechanism of the Effect of High-Intensity Training on Urinary Metabolism in Female Water Polo Players Based on UHPLC-MS Non-Targeted Metabolomics Technique

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