2015
DOI: 10.3892/ijo.2015.2914
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Abstract: Abstract.Hydrogen sulfide (H 2 S) takes part in a diverse range of intracellular pathways and hss physical and pathological properties in vitro and in vivo. However, the effects of H 2 S on cancer are controversial and remain unclear. The present study investigates the effects of H 2 S on liver cancer progression via activating NF-κB pathway in PLC/PRF/5 hepatoma cells.

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Cited by 56 publications
(43 citation statements)
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“…It has been reported that COX-2 pathway is closely associated with tumor cell growth and is a crucial molecule in the development of malignant tumors, and angiogenesis (15,16), anti-apoptosis (17), invasiveness (18) and proliferation (19). In the present study, we found that NS-398 (an inhibitor of COX-2) increased caspase-3 expression, which is consistent with previous research results (17,31). In addition, treatment of cells with 400 µmol/l NaHS for 24 h promoted the expression level of COX-2, along with the NaHS-induced pro-proliferative effect and anti-apoptosis.…”
Section: Discussionsupporting
confidence: 82%
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“…It has been reported that COX-2 pathway is closely associated with tumor cell growth and is a crucial molecule in the development of malignant tumors, and angiogenesis (15,16), anti-apoptosis (17), invasiveness (18) and proliferation (19). In the present study, we found that NS-398 (an inhibitor of COX-2) increased caspase-3 expression, which is consistent with previous research results (17,31). In addition, treatment of cells with 400 µmol/l NaHS for 24 h promoted the expression level of COX-2, along with the NaHS-induced pro-proliferative effect and anti-apoptosis.…”
Section: Discussionsupporting
confidence: 82%
“…H 2 S promotes the supply of nutrients and blood to the tumor cells and tissues (24). Our latest research also demonstrated that exogenous H 2 S promoted cancer cell proliferation/ anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathway (31). Furthermore, to the best of our knowledge, no study exists focused on the effect of exogenous H 2 S on C6 glioma cells and its potential mechanisms.…”
Section: Introductionmentioning
confidence: 92%
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“…In the liver, H 2 S can exert hepatoprotective effects via miR-34a-mediated modulation of the nuclear factor erythroid 2-related factor 2 signaling pathway (41). Recently, our group demonstrated that exogenous H 2 S promoted PLC/PRF/5 cell proliferation, anti-apoptosis, angiogenesis and migration by amplifying the activation of the NF-κB signaling pathway (24). To further investigate the effect of exogenous H 2 S on PLC/PRF/5 cells, PLC/PRF/5 cells were treated with 500 µmol/l NaHS for 24 h. The results revealed that exogenous H 2 S increased PLC/PRF/5 cell growth, angiogenesis and migration, as evidenced by an increase in cell viability, migration, expression of MMP-2 and production of VEGF, and a decrease in apoptotic rate and expression of caspase-3 (one of the apoptotic factors) (42), which is consistent with the findings of our previous study (23).…”
Section: The Stat3-cox-2 Signaling Pathway Participates In Nahs-inducmentioning
confidence: 99%
“…In the liver, H 2 S can be catalyzed by both cystathionine b-synthase (CBS) and cystathionine g-lyase (CSE) (23). Accumulating studies have demonstrated that H 2 S is involved in the pathophysiological progression of tumors (24)(25)(26)(27). However, the potential mechanism of H 2 S in cancer is unclear and controversial.…”
Section: Introductionmentioning
confidence: 99%