Exogenous Heme Functionally Reconstitutes Hepatic Cytochrome P-450 in Vivo

Farrell, Geoffrey C.; Correia, Maria Almira; Schmid, Rudi; Montellano, Paul R. Ortiz de; Kunze, Kent L.

doi:10.1016/b978-0-12-187701-9.50115-7

Microsomes, Drug Oxidations and Chemical Carcinogenesis 1980

DOI: 10.1016/b978-0-12-187701-9.50115-7

|View full text |Cite

Exogenous Heme Functionally Reconstitutes Hepatic Cytochrome P-450 in Vivo

Geoffrey C. Farrell¹,

Maria Almira Correia²,

Rudi Schmid³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2013

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

Sasaki

Matumoto

Ikenaka

et al. 2013

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Leghorn chickens were orally administered FZ once a day for 4 consecutive days. FZ-treated chickens showed an increase in multiple CYP-related activities, however, rats treated with FZ did not show these changes. In chickens, treatment with FZ also induced production of microsomal CYP2C6-like apoprotein. The present study demonstrated that FZ caused a multiple-type induction of CYP-related activities in chickens, but not in rats.

show abstract

Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

Sasaki

Matumoto

Ikenaka

et al. 2013

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

334 Leonard St

Brooklyn, NY 11211

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exogenous Heme Functionally Reconstitutes Hepatic Cytochrome P-450 in Vivo

Cited by 1 publication

References 5 publications

Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

Contact Info

Product

Resources

About