“…There are many ways of slicing a molecule to obtain scaffold–decoration pairs for training a decorator model . Recently, the exhaustive slicing of single bonds according to RECAP rules has been explored. , Whereas this approach appears natural at a glance, it is not always effective for a wet lab chemist attempting to synthesize the proposed compounds . Whereas the default RECAP rules, which include 11 bond cleavage types (amide, amine, ester, urea, ether, olefin, quaternary nitrogen, aliphatic carbon with aromatic nitrogen, lactam nitrogen with aliphatic carbon, aromatic carbon with aromatic carbon, and sulphonamide), aim to slice the molecules and identify preferred structural motifs, they still leave some cleaving possibilities out.…”