Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma

Schleich, Florence; Zanella, Delphine; Stefanuto, Pierre‐Hugues; Bessonov, Kyrylo; Smolinska, Agnieszka; Dallinga, Jan W.; Henket, Monique; Paulus, Virginie; Guissard, Françoise; Graff, Sophie; Moermans, Catherine; Wouters, Emiel F.M.; Steen, Kristel Van; Schooten, Frederik‐Jan van; Focant, Jean‐François; Louis, Renaud

doi:10.1164/rccm.201811-2210oc

Cited by 126 publications

(139 citation statements)

References 35 publications

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“…36 An editorial about the study labeled adult asthma as ''less active Type 2 immunity'' with either ''eosinophilic or neutrophilic'' involvement. 37 An editorial reviewing the work of Schleich et al, 38 which investigated the volatile gas exhalate of asthmatics, stated there ''is a need for type 2 and increasingly nontype 2 asthma.'' inflammatory profiling.…”

Section: Pediatric Asthmamentioning

confidence: 99%

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Hopp

2020

Pediatric Allergy, Immunology, and Pulmonology

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The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.

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Section: Pediatric Asthmamentioning

confidence: 99%

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Hopp

2020

Pediatric Allergy, Immunology, and Pulmonology

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“…Easy-to-use devices measuring exhaled air parameters were highlighted on several occasions as valuable support for the rapid, noninvasive and early detection of asthma, especially in symptomatic children [21]. Molecular biomarkers such as exhaled volatile organic compounds (VOCs) can be detected by electronic nose technology for metabolomic analyses [22] and VOCs measured by gas chromatography-time-of-flight mass spectrometry have been able to discriminate between various asthma inflammatory phenotypes [23]. The Inflammacheck (Exhalation Technology, Cambridge, UK) device could detect exhaled hydrogen peroxide as a marker of lung disease, including mild and severe asthma [24].…”

Section: Biomarkersmentioning

confidence: 99%

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

et al. 2020

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The European Respiratory Society (ERS) International Congress 2019 in Madrid, Spain, was a platform for scientific discussion of the highest quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory field. This article discusses some of the high-quality research studies presented at that Congress, with a focus on airway diseases, including asthma, COPD, small airways, bronchiectasis and cough, presented through the Airway Diseases, Asthma and COPD Assembly (Assembly 5) of the ERS. The authors establish the key take-home messages of these studies, compare their findings and place them into context of current understanding.

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“…As previously said, the definition of severe asthma requires the exclusion of poor adherence to ICS/LABA. We have previously shown that monitoring a set of VOCs permitted to detect the presence of sputum eosinophilic and neutrophilic inflammation [7,8]. As inhaled corticosteroids act in part by decreasing local eosinophilic inflammation, this suggests that VOCs are promising biomarkers that would possibly be used to detect poor adherence to ICS.…”

Section: @Erspublicationsmentioning

confidence: 99%