Exhaled Nitric Oxide Measurement Is Not Useful for Predicting the Response to Inhaled Corticosteroids in Subjects With Chronic Cough

Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath

“…Of these, six 69,71,72,[82][83][84]86,87 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK. l Nine studies [73][74][75][76][77]81,85,88,89,91 recruited patients who could be considered 'difficult to diagnose' and are located at other points along the diagnostic pathway. These patients had already undergone some of the tests in the UK pathway and had tested negative for asthma thus far.…”

“…One further study 71,72 reported a subset of difficult-to-diagnose patients from a larger cohort of patients at position A (see Figure 8). Of these, seven studies 73,74,76,77,81,85,88 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK. l One study 78 recruited patients with suspected EIB.…”

“…These studies are Schneider et al, 69 Schneider et al, 71,72 Schleich et al, 77 Prieto et al, 76 El Halawani et al, 78 Hsu et al, 73 Hahn et al, 74 Pedrosa et al, 85 Heffler et al, 82 Smith et al 83 (de la Barra et al 84 reports additional analyses to Smith et al 83 ) Smith et al, 86 Bobolea et al, 88 Cordeiro et al 87 and Katsoulis et al…”

“…Quality assessment of studies relevant to the decision problem Sixteen studies (18 citations 69,[71][72][73][74][76][77][78][80][81][82][83][84][85][86][87][88]92 ) exploring FeNO measurement for the diagnosis of asthma in adults were assessed for quality according to QUADAS-2 criteria for diagnostic accuracy studies. 38 Although based on the same data as the study by Smith et al, 83 the study by de la Barra et al 84 was assessed separately as the analysis was different.…”

“…those patients presenting with clinical signs of asthma or a subset thereof or patients at a definable point in the UK pathway). However, it was unclear in seven cases 73,74,76,77,81,87,92 whether a consecutive sample was recruited.…”