Exhaled nitric oxide level during and after heavy exercise in athletes with exercise-induced hypoxaemia

Kippelen, Pascale; Caillaud, Corinne; Robert, E; Masmoudi, Kaouthar; Préfaut, Christian

doi:10.1007/s00424-002-0816-y

Cited by 20 publications

(22 citation statements)

References 50 publications

(70 reference statements)

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“…There was discordance among the tests for the frequency of cough. Bradykinin induced the most cough and exercise-induced the least (20). To our knowledge, the study by Suguikawa et al (3) is the sole paper that have objectively monitored cough in relation to exercise.…”

Section: Discussionmentioning

confidence: 99%

Cough and Exhaled Nitric Oxide Levels: What Happens with Exercise?

et al. 2013

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Cough associated with exertion is often used as a surrogate marker of asthma. However, to date there are no studies that have objectively measured cough in association with exercise in children. Our primary aim was to examine whether children with a pre-existing cough have an increase in cough frequency during and post-exercise. We hypothesized that children with any coughing illness will have an increase in cough frequency post-exercise regardless of the presence of exercise-induced broncho-constriction (EIB) or atopy. In addition, we hypothesized that Fractional exhaled nitric oxide (FeNO) levels decreases post-exercise regardless of the presence of EIB or atopy. Children with chronic cough and a control group without cough undertook an exercise challenge, FeNO measurements and a skin prick test, and wore a 24-h voice recorder to objectively measure cough frequency. The association between recorded cough frequency, exercise, atopy, and presence of EIB was tested. We also determined if the change in FeNO post exercise related to atopy or EIB. Of the 50 children recruited (35 with cough, 15 control), 7 had EIB. Children with cough had a significant increase in cough counts (median 7.0, inter-quartile ranges, 0.5, 24.5) compared to controls (2.0, IQR 0, 5.0, p = 0.028) post-exercise. Presence of atopy or EIB did not influence cough frequency. FeNO level was significantly lower post-exercise in both groups but the change was not influenced by atopy or EIB. Cough post-exertion is likely a generic response in children with a current cough. FeNO level decreases post-exercise irrespective of the presence of atopy or EIB. A larger study is necessary confirm or refute our findings.

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Section: Discussionmentioning

confidence: 99%

Cough and Exhaled Nitric Oxide Levels: What Happens with Exercise?

et al. 2013

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“…7 Prior to FeNO measurement, strenuous physical exercise, eating, drinking, or smoking must be avoided for at least 1 hour. [10][11][12] Some foods containing nitrates may increase FeNO levels, 10 and caffeinated food and beverages showed conflicting associations with FeNO. 13,14 Smoking causes acute and chronic reduction in FeNO levels.…”

Section: Subject-related Factorsmentioning

confidence: 99%

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease

Kim

Eckel

Kim

et al. 2016

Allergy Asthma Immunol Res

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“…The increased attention to personalised medicine, which for asthma includes basing treatment on objective airway inflammation,11 is reflected by interest in our previous systematic review 12. We present an update to our previous review12 by providing an overview of three recent related Cochrane reviews,13–15 each of which addressed a different question as per the Participants Intervention Camparator Outcomes (PICO) framework.…”

Section: Introductionmentioning

confidence: 99%