Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma

Romieu, Isabelle; Barraza‐Villarreal, Albino; Escamilla-Núñez, Consuelo; Almstrand, Ann-Charlotte; Díaz-Sánchez, David; Sly, Peter D.; Olin, Anna‐Carin

doi:10.1016/j.jaci.2007.12.004

Cited by 127 publications

(124 citation statements)

References 32 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…In previous work from the CCCEH, pregnant Dominican and AfricanAmerican women, aged [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (2,15). A PAH mixture that reproduced the PAH exposure of the CCCEH participants (Table 1) was produced for our cellular experiments.…”

Section: Pah Mixturementioning

confidence: 99%

“…Several pathways appear important. In one, air pollutants such as diesel, particulate matter, and metals, known triggers of asthma, may induce oxidative stress pathways, causing the formation of excessive reactive oxygen species in the airways and tissue inflammation (3,4,(26)(27)(28)(29). In a second pathway, exposure to diesel may provide a strong adjuvant for allergic sensitization, and such exposure was shown to up-regulate allergic immune mechanisms in the airways (4,(30)(31)(32)(33).…”

Section: Treatment With Pahs Reduces the Function Of B 2 Ar (Procatermentioning

confidence: 99%

See 1 more Smart Citation

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Factor

Akhmedov

McDonald

et al. 2011

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Incomplete combustion produces a pollutant mixture that includes polycyclic aromatic hydrocarbons (PAHs). Previous work by the Columbia Center for Children's Environmental Health (CCCEH) and others linked exposure to PAH with symptoms of asthma and other adverse health effects in young children. Inhaled b 2 -adrenergic agonists are mainstays in the treatment of reactive airway diseases. These exogenous catecholamines engage membrane-bound b 2 -adrenergic receptors (b 2 AR) on airway epithelial and smooth muscle cells to cause airway dilation. We hypothesized that exposure to PAH might similarly interfere with the function of b 2 AR in airway epithelial or smooth muscle cells, reducing the efficacy of a medication important for the treatment of asthma symptoms. A PAH mixture was devised, based on ambient levels measured prenatally among a cohort of pregnant women participating at the CCCEH. Primary airway epithelial and smooth muscle cells were exposed to varying concentrations of the PAH mixture, and expression, function, and signaling of b 2 AR were assessed. Murine tracheal epithelial cells and human airway smooth muscle cells, after exposure to a PAH mixture, exhibited reduced expression and function of b 2 AR. These findings support our hypothesis that environmentally relevant PAHs can impede b 2 AR-mediated airway relaxation, and suggest a new paradigm where air pollutants not only contribute to the pathogenesis of childhood asthma, but also diminish responsiveness to standard therapy.

show abstract

Section: Pah Mixturementioning

confidence: 99%

Section: Treatment With Pahs Reduces the Function Of B 2 Ar (Procatermentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Factor

Akhmedov

McDonald

et al. 2011

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

show abstract

“…Escamilla-Nuñez et al 2008;Romieu et al 2008). Recent epidemiological studies report neuro-inflammation in otherwise healthy children residing in MCMA (Calderón-Garcidueñas et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Impact of environmental and social attitudes, and family concerns on willingness to pay for improved air quality: a contingent valuation application in Mexico City

Filippini

Martínez-Cruz

2016

Lat Am Econ Rev

View full text Add to dashboard Cite

By means of a single-bounded, referendum format contingent valuation, this paper estimates willingness to pay (WTP) for improved air quality among residents of Mexico City Metropolitan Area (MCMA). Findings from this paper illustrate heterogeneity in WTP associated with environmental and social attitudes, and family concerns. For instance, WTP is higher than average if respondents state a very high priority to air pollution but smaller than average if respondent's household contains more adults than the sample median. This contingent valuation exercise provides elements to carry out cost-benefit analysis of environmental policies both recently implemented and currently under discussion in the MCMA context. For instance, a cost-benefit analysis using estimates from this paper suggests benefits from improved air quality surpass the costs of investing in hybrid buses. Usefulness of this study is underscored by pointing out recent evidence suggesting that (1) air pollution in MCMA has larger health impacts than in similar cities located in developed countries, and (2) policies tackling air pollution in MCMA have had no impact on pollution levels.

show abstract

“…7 Several oxidative stress markers are measurable in EBC. 8 The tar phase of smoke contains the hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ). 9 H 2 O 2 is a direct marker of air-space oxidative burden and measurable in EBC.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Levels in Exhaled Breath Condensate Associated With COPD and Smoking

Inonu¹,

Doruk²,

Sahin³

et al. 2012

Respir Care

View full text Add to dashboard Cite

BACKGROUND: COPD is characterized by chronic air-flow limitation. Smoking is the most important factor in the pathogenesis of COPD. Smoking is associated with increased oxidative stress in the lungs. In this study our aim was to evaluate the differences in the burden of oxidative stress in patients with COPD, smokers, and non-smokers by measuring hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), and 8-isoprostane levels in the exhaled breath condensate (EBC) samples. METHODS: Eighty subjects were included in the study. Group I (no. ‫؍‬ 25) had COPD, Group II (no. ‫؍‬ 26) was smokers, and Group III (no. ‫؍‬ 29) was nonsmokers. The severity of the COPD and dyspnea was assessed according to the results of pulmonary function tests (PFTs) and Medical Research Council (MRC) scale. RESULTS: The mean age of the subjects was 58 ؎ 8.9 years. While 8-isoprostane and H 2 O 2 levels were significantly higher in subjects with COPD (44.8 ؎ 40.2 pg/mL and 1.9 ؎ 0.8 mol/L) and smokers (41.3 ؎ 26 pg/mL and 1.7 ؎ 0.7 mol/L) than non-smokers (15.8 ؎ 6.9 pg/mL and 0.8 ؎ 0.4 mol/L), levels were similar between smokers and COPD subjects. MDA levels were similar between the 3 groups (P ‫؍‬ .31). There was no correlation between 8-isoprostane and H 2 O 2 levels and PFT parameters. There was a significant positive correlation between dyspnea grade on the MRC scale and 8-isoprostane levels (r ‫؍‬ 0.805, P < .001). CON-CLUSIONS: Even if respiratory function tests are within normal limits, oxidant burden in lungs of smokers is equivalent to that in COPD patients. 8-isoprostane could be useful in assessing symptom severity and health status of COPD patients.

show abstract

Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma

Cited by 127 publications

References 32 publications

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Impact of environmental and social attitudes, and family concerns on willingness to pay for improved air quality: a contingent valuation application in Mexico City

Oxidative Stress Levels in Exhaled Breath Condensate Associated With COPD and Smoking

Contact Info

Product

Resources

About

Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma

Cited by 127 publications

References 32 publications

Polycyclic Aromatic Hydrocarbons Impair Function of β2-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Polycyclic Aromatic Hydrocarbons Impair Function of β2-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Impact of environmental and social attitudes, and family concerns on willingness to pay for improved air quality: a contingent valuation application in Mexico City

Oxidative Stress Levels in Exhaled Breath Condensate Associated With COPD and Smoking

Contact Info

Product

Resources

About

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells

Polycyclic Aromatic Hydrocarbons Impair Function of β₂-Adrenergic Receptors in Airway Epithelial and Smooth Muscle Cells