As a result of the analysis of 1850 medical records of consultations, examination of 1159 patients of pediatric and adult therapeutic dental appointments and an in-depth examination of 89 patients, it was found that the prevalence of the dry form of exfoliative cheilitis in people of different ages is 1.55%, the exudative form of exfoliative cheilitis occurs in 0.27% of cases among patients with pathology of the oral mucosa and lips. Local and general unfavorable factors are observed in patients with cheilitis with a slightly higher, but statistically insignificant, frequency than among healthy people, but the role of psycho-emotional stress in exacerbating the disease is noted in 43.5% of patients.