Exercise Training on Disease Control and Quality of Life in Asthmatic Children

Fanelli, Adriana; Cabral, Anna; Neder, J. Alberto; Martins, Mílton A.; Carvalho, Celso Ricardo Fernandes

doi:10.1249/mss.0b013e3180d099ad

Cited by 185 publications

(251 citation statements)

References 22 publications

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“…These effects have been mainly attributed to an improvement in the ventilatory capacity and physical fitness as well as a decrease in dyspnea, exercise-induced bronchospasm severity, and use of corticosteroids (7,13,36,46). These clinical benefits have also suggested a possible anti-inflammatory effect of aerobic training on asthma.…”

Section: Discussionmentioning

confidence: 99%

“…The performance of aerobic training in asthmatic patients triggers several beneficial effects such as the improvement in physical fitness and ventilatory capacity and a decrease in asthma-related symptoms, exercise-induced bronchospasm, and daily use of inhaled steroids (7,13,36,46). Aerobic training has been shown to modulate the immune response in healthy individuals; however, its effect depends on training intensity (42).…”

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confidence: 99%

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Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling

Vieira¹,

Andrade²,

Duarte³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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In addition, some studies demonstrated that aerobic training decreases chronic allergic inflammation in the airways; however, its effects on the pulmonary vessels and parenchyma have not been previously evaluated. Our objective was to test the hypothesis that aerobic conditioning reduces inflammation and remodeling in pulmonary vessels and parenchyma in a model of chronic allergic lung inflammation. Balb/c mice were sensitized at days 0, 14, 28, and 42 and challenged with ovalbumin (OVA) from day 21 to day 50. Aerobic training started on day 21 and continued until day 50. Pulmonary vessel and parenchyma inflammation and remodeling were evaluated by quantitative analysis of eosinophils and mononuclear cells and by collagen and elastin contents and smooth muscle thickness. Immunohistochemistry was performed to quantify the density of positive cells to interleukin (IL)-2, IL-4, IL-5, interferon-␥, IL-10, monocyte chemotatic protein (MCP)-1, nuclear factor (NF)-B p65, and insulin-like growth factor (IGF)-I. OVA exposure induced pulmonary blood vessels and parenchyma inflammation as well as increased expression of IL-4, IL-5, MCP-1, NF-B p65, and IGF-I by inflammatory cells were reduced by aerobic conditioning. OVA exposure also induced an increase in smooth muscle thickness and elastic and collagen contents in pulmonary vessels, which were reduced by aerobic conditioning. Aerobic conditioning increased the expression of IL-10 in sensitized mice. We conclude that aerobic conditioning decreases pulmonary vascular and parenchymal inflammation and remodeling in this experimental model of chronic allergic lung inflammation in mice.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling

Vieira¹,

Andrade²,

Duarte³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…(5) Although swimming is considered an ideal modality for individuals with asthma, there are reports suggesting that elite swimmers have shown a high incidence of bronchial hyperresponsiveness and asthma symptoms, as well as a high number of eosinophils and neutrophils in induced sputum, when compared with athletes in other endurance sports, (11) suggesting that the chronic exposure to chlorine derivatives induces airway inflammation. (24) The higher incidence of asthma among amateur swimmers not previously diagnosed with asthma reinforces the hypothesis that the type of sport can truly be an essential factor in the development of asthma symptoms. Curiously, counter to the idea that individuals with asthma tend to choose swimming precisely because of their respiratory problem, (9) most of the subjects interviewed in the present study reported that the choice was based exclusively on personal preference for the sport.…”

Section: Discussionmentioning

confidence: 58%

Frequência de sintomas de asma e de redução da função pulmonar entre crianças e adolescentes nadadores amadores

Fiks

Santos

Antunes³

et al. 2009

J. bras. pneumol.

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Objective: To investigate the incidence of asthma symptoms in young amateur swimmers, and to describe the clinical treatment of the children with asthma in a private sports club in the city of São Paulo, Brazil. Methods: The study included 171 amateur swimmers, ranging from 6 to14 years of age. All of the participants or their legal guardians were asked to complete the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, and 119 were submitted to pulmonary function testing at rest. Results: The overall incidence of asthma symptoms (ISAAC score ≥ 6) among the swimmers was 16.8%. Of the 119 swimmers submitted to spirometry, 39 (32.7%) presented spirometric alterations (FEV 1 /FVC < 0.75). Among those with an ISAAC score ≥ 6, there were 10 (31.2%) who stated that they were receiving no asthma treatment. Of those who reported receiving pharmacological treatment, 24% made use of bronchodilators but not of corticosteroids. Conclusions: The incidence of asthma symptoms and pulmonary function alterations among amateur swimmers within the 6-14 age bracket was high. In addition, a relevant proportion of these athletes were receiving no treatment.Keywords: Asthma/therapy; Asthma/diagnosis; Child; Swimming; Exercise. ResumoObjetivo: Investigar a frequência de sintomas de asma entre crianças e adolescentes nadadores amadores e descrever o tratamento clínico entre as crianças asmáticas em um clube esportivo privado na cidade de São Paulo. Métodos: Foram incluídos no estudo 171 nadadores amadores de 6 a 14 anos de idade. Todos os participantes ou seus responsáveis foram solicitados a responder o questionário International Study of Asthma and Allergies in Childhood (ISAAC), e 119 realizaram prova de função pulmonar em repouso. Resultados: A frequência geral de sintomas de asma (ISAAC ≥ 6 pontos) entre os nadadores foi de 16,8%. Entre os 119 nadadores que realizaram a espirometria, 39 (32,7%) apresentaram alterações espirométricas (VEF 1 /CVF < 0,75). Entre os sujeitos com escore ISAAC ≥ 6, 10 (31,2%) alegaram não realizar nenhum tipo de tratamento para a doença. Daqueles que afirmaram realizar tratamento medicamentoso, 24% faziam uso de broncodilatadores mas não de corticosteroides. Conclusões: A frequência de sintomas de asma e de alterações da função pulmonar em nadadores amadores de 6 a 14 anos foi elevada. Além disso, uma proporção considerável destes atletas não recebia tratamento.

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“…Aerobic physical training triggers several beneficial effects in asthmatic patients such as improvement in physical fitness and ventilatory capacity and a decrease in asthma-related symptoms, exerciseinduced bronchospasm, and daily use of inhaled steroids (15)(16)(17)(18). Other investigators have demonstrated that asthmatic patients submitted to an aerobic physical training program also present improved respiratory and peripheral muscle strength and function (19,20).…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

Durigan

Peviani

Russo

et al. 2009

Braz J Med Biol Res

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We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trained (C); 2) ovalbumin sensitized (OA, 20 μg per mouse); 3) non-sensitized and trained at 50% maximum speed -low intensity (PT50%); 4) non-sensitized and trained at 75% maximum speed -moderate intensity (PT75%); 5) OA-sensitized and trained at 50% (OA+PT50%), 6) OA-sensitized and trained at 75% (OA+PT75%). There was no difference in muscle fiber cross-sectional area among groups and no difference in atrogin-1 and MuRF1 expression between C and OA groups. All exercised groups showed significantly decreased expression of atrogin-1 compared to C (1.01 ± 0.2-fold): PT50% = 0.71 ± 0.12-fold; OA+PT50% = 0.74 ± 0.03-fold; PT75% = 0.71 ± 0.09-fold; OA+PT75% = 0.74 ± 0.09-fold. Similarly significant results were obtained regarding MuRF1 gene expression compared to C (1.01 ± 0.23-fold): PT50% = 0.53 ± 0.20-fold; OA+PT50% = 0.55 ± 0.11-fold; PT75% = 0.35 ± 0.15-fold; OA+PT75% = 0.37 ± 0.08-fold. A short period of OA did not induce skeletal muscle atrophy in the mouse tibialis anterior muscle and aerobic training at low and moderate intensity negatively regulates the atrophy pathway in skeletal muscle of healthy mice or mice with allergic lung inflammation.

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Exercise Training on Disease Control and Quality of Life in Asthmatic Children

Abstract: Supervised exercise training might be associated with beneficial effects on disease control and quality of life in asthmatic children. These data suggest an adjunct role of physical conditioning on clinical management of patients with more advanced disease.

Cited by 185 publications

References 22 publications

Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling

Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling

Frequência de sintomas de asma e de redução da função pulmonar entre crianças e adolescentes nadadores amadores

Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

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