Exercise intensity modulates nitric oxide and blood pressure responses in hypertensive older women

Santana, Hugo; Moreira, Sérgio Rodrigues; Asano, Ricardo Yukio; Sales, Marcelo Magalhães; Córdova, Cláudio; Campbell, Carmen Sílvia Grubert; Espíndola, Foued Salmen; Sposito, Andrei C.; Nóbrega, Otávio de Tolêdo; Simões, Herbert Gustavo

doi:10.1007/s40520-013-0017-x

Cited by 50 publications

(47 citation statements)

References 29 publications

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“…These mechanisms might in part explain the PEH response, taking into account that bradykinin and NO release are related to PEH. 20,66 The present study has some limitations. We only evaluated insertion/deletion polymorphisms of the ACE gene, and did not include other polymorphisms or parameters of the RAAS, such as plasma renin levels, ACE plasma levels, angiotensin levels and angiotensinogen.…”

Section: Discussionmentioning

confidence: 85%

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

Goessler

Cornelissen

Oliveira

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Hypothesis/Introduction: Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses. Materials and methods: Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking the next morning. Results: Overall, systolic BP was somewhat lower following the walking session (p=.06), which could be attributed to a consistently lower systolic BP for 5 h after exercise (p-interaction<.04) compared with control rest. Similarly, II/ID individuals had a lower systolic BP (p-interaction=.02) and diastolic BP (p-interaction<.01) for 5 h after walking compared with control rest. Among DD individuals, a single walk did not induce a reduction in BP (p-interaction>.05). Conclusions: Our results showed that postexercise hypotension can occur after a walk at moderate intensity in carriers of the I allele; we were not able to demonstrate this in DD individuals. Our results suggest that genetic variation in the ACE gene might affect the BP response to exercise, although more research is needed to confirm these findings.

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Section: Discussionmentioning

confidence: 85%

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

Goessler

Cornelissen

Oliveira

et al. 2015

J Renin Angiotensin Aldosterone Syst

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“…Um deles avaliou a HPE até 15 minutos (Cal Abad et al, 2010) e outro até 20 minutos após o exercício (Jones et al, 2007). Outros avaliaram até 60 minutos (Casonatto et al, 2011;Christofaro et al, 2008;MacDonald et al, 1999MacDonald et al, , 2000Rossow et al, 2010;Santana et al, 2011Santana et al, , 2013, até 90 minutos (Forjaz, Matsudaira, et al, 1998;Forjaz, Santaella, et al, 1998;Lizardo et al, 2007) e até 120 minutos (Cunha et al, 2006) após o exercício. Outros estudos verificaram a resposta ambulatorial da HPE, observando essa em até 7 horas (Mota et al, 2009;Pescatello et al, 1999) ou em 24 horas (Ferreira et al, 2013;Forjaz et al, 2000Forjaz et al, , 2004Pescatello et al, 2003Pescatello et al, , 2004.…”

Section: Discussionunclassified

“…Um estudo (Santana et al, 2011) citou se houve perdas e retiradas (tabela 2). Foi possível observar ainda que 14 dos 20 artigos selecionados são randomizadoscontrolados (Casonatto et al, 2011;Christofaro et al, 2008;Ferreira et al, 2013;Forjaz et al, 2000Forjaz et al, , 2004Forjaz, Matsudaira, et al, 1998;Forjaz, Santaella, et al, 1998;Jones et al, 2007;Mota et al, 2009;Pescatello et al, 1999Pescatello et al, , 2003Pescatello et al, , 2004Santana et al, 2011Santana et al, , 2013. Neste estudo, a randomização foi um crité-rio de entrada para seleção dos artigos elegí-veis, porém, a maioria não citou quais os métodos utilizados, não sendo possível verificá-los quanto a sua adequação.…”

Section: Perdas E Retiradasunclassified

“…A magnitude da HPE foi obtida calculando a diferença dos valores de pressão obtidos entre a condição pós-exercício e pré-exercício (Cal Abad, da Silva, Mostarda, da Silva, & Irigoyen, 2010;Casonatto et al, 2011;Christofaro et al, 2008;Cunha et al, 2006;Forjaz et al, 2004;Forjaz, Matsudaira, et al, 1998;Forjaz, Santaella, et al, 1998;Lizardo et al, 2007;MacDonald, MacDougall, & Hogben, 1999;MacDonald et al, 2000;Mota et al, 2009;Pescatello et al, 1999Pescatello et al, , 2003Pescatello et al, , 2004Rossow et al, 2010;Santana et al, 2011Santana et al, , 2013 ou entre a sessão exercício e a sessão controle (Ferreira et al, 2013;Forjaz et al, 2000;Jones et al, 2007), citadas como estatisticamente significante nos artigos (p≤ 0.05).…”

Section: Perdas E Retiradasunclassified

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Magnitude da hipotensão pós-exercício aeróbio agudo: Uma revisão sistemática dos estudos randomizados

Marques-Silvestre¹,

Brasileiro-Santos²,

Oliveira³

et al. 2014

Motricidade

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ARTIGO DE REVISÃO | REVIEW ARTICLE RESUMOObjetivou-se revisar sistematicamente estudos randomizados sobre a magnitude da hipotensão pós-exercício (HPE) em adultos. Consultaram-se as bases Pubmed, Scielo e Lilacs, combinando os indexadores "exercise" e "hypotension", sendo encontrados 1336 estudos. Destes, excluíram-se 1268 por títu-los, 37 por resumos, 10 não randomizados, 1 por repetição de dados, restando 20. Estes foram avaliados segundo os itens de randomização, mascaramento, sigilo de alocação, análise por intenção de tratar e quantitativamente pela Escala de Jadad. As reduções das pressões sistólica (PAS) e diastólica (PAD) em normotensos foram inferiores à dos hipertensos (−9±3 vs −11±6 mmHg e −5±2 vs −8±6 mmHg, respetivamente). Em ambos os grupos, os indivíduos ativos apresentaram HPE maior que os sedentários (normotensos: PAS −10±4 vs −8±1 mmHg; PAD −5±1 vs −4±1 mmHg; hipertensos: PAS −16±4 vs −9±2 mmHg; PAD −7±4 vs −5±3 mmHg, respetivamente). Nestes estudos, a magnitude da HPE variou entre −4 a −19 mmHg para PAS e −2 a −9 mmHg para PAD, valores que dependem tanto das características da amostra, seus estágios pressóricos iniciais, sexo e nível de atividade física, como também do protocolo de exercício utilizado, não havendo consenso sobre a influência da sua duração ou da intensidade do exercício. Palavras-chave: exercício, pressão arterial, hipotensão pós-exercício ABSTRACTThe objective was to carry out a systematic review of randomized trials on the magnitude of post exercise hypotension (PEH) in adults. 1336 studies were retrieved from PubMed, Scielo and Lilacs, after searching "exercise" and "hypotension". 1268 papers were excluded by titles, 37 by abstracts, 10 were nonrandomized, 1 by repeating data, leaving 20. These studies were evaluated according to the randomization, blinding, allocation concealment, analysis by intention to treat and quantitatively by the Jadad Scale. The average reductions in systolic (SBP) and diastolic (DBP) of the normotensive were lower than hypertensive (−9±3 vs. −11±6 mmHg and −12±2 vs. −8±6 mmHg, respectively) in both groups, active individuals had greater PEH than sedentary individuals (normotensive SBP −10±4 vs. −8±1 mmHg, PAD −5±1 vs. −4±1; hypertensive SBP −16±4 vs −9±2 mmHg; PAD −7±4 vs. −5±3 mmHg, respectively). In randomized studies the magnitude of PEH ranged from −4 to −19 mmHg for SBP and −2 to −9 mm Hg for DBP values according to the sample characteristics (blood pressure early stages, gender and level of physical activity) and the exercise protocols selected (i.e., there is no consensus on the influence of duration and intensity).

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“…Mean arterial pressure (MAP) is a product of cardiac output and systematic vascular resistance (MacDonald., 2002). Given that PEH May be result from reductions in cardiac output, total peripheral resistance, or both (Santana et al, 2013). Therefore, the calculation of this parameter can help us when discussing the results.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

Phys. educ. stud.

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Exercise intensity modulates nitric oxide and blood pressure responses in hypertensive older women

Abstract: Exercise intensity and NO release may exert a role in eliciting PEH in mildly hypertensive elderly women.

Cited by 50 publications

References 29 publications

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients

Magnitude da hipotensão pós-exercício aeróbio agudo: Uma revisão sistemática dos estudos randomizados

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