Exercise improves cytokine profile in HIV-infected people: A randomized clinical trial

Pedro, Rafael Evangelista; Cândido, Nádia Biage; Guariglia, Débora Alves; Melo, Berildo de; Bertolini, Dennis Armando; Peres, Sidney Barnabé; Moraes, Solange Marta Franzói de

doi:10.1016/j.cyto.2017.06.019

Cited by 17 publications

(23 citation statements)

References 39 publications

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“…All Randomized and Case controlled trials that reported inflammatory biomarkers as an outcome were included. Two (2) studies employed the combination of aerobic and Resistance Exercises [35, 36, 61, 62]. Three (3) studies involved Resistance exercises only [44, 64, 80] while three studies utilized just aerobic exercises [59, 60, 63] Studies on Resistance exercises had two studies with Control groups that maintained their normal daily activities/habits [44, 80] and a study [64], with ‘No-exercise’ group as control.…”

Section: Resultsmentioning

confidence: 99%

“…For Aerobic exercise studies; Bonato et al [56], involved a ‘Strength-walk’ control group, Dudgeon et al [60] had a ‘No-exercise’ control while Roos et al [63], engaged a control group that maintained their standard clinic management. For the studies that combined both aerobic and resistant exercises; Pedro et al [62], utilized Recreational activities as control, and Dudgeon et al [61], maintained a ‘No-exercise’ control.…”

Section: Resultsmentioning

confidence: 99%

“…Participants were all HIV adults both male and female with CD4+ cell count ranging from ≤150 cell/mm 3 to ≥1000 cells/mm 3 with the mean age of between 18 to 60 years and were consistent on ART regimen. Three studies had participants located in Brazil [44, 62, 80], two studies were in Columbia [60, 61] while three studies were done in South Africa, USA, and New Zealand respectively [58, 63, 64].…”

Section: Resultsmentioning

confidence: 99%

“…For the inflammatory biomarkers; three studies [44, 59, 63] reported on high sensitivity CRP, four studies reported on Interleukin-6 [60, 61, 64, 80]; three studies reported on either Interleukin-10 [44, 62, 64] and Interleukin-1β [60, 64, 80]. Also, two studies reported on Interleukin-4, 6, 10 [62, 64] or Interleukin-8 [44, 62], while one study each reported on either interleukin-5 [62], Tumor Necrosis Factor [64], Soluble Tumor Necrosis Factor-II Receptor [61], Interferon-gamma [64], Interleukin-2 [64].…”

Section: Resultsmentioning

confidence: 99%

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Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

et al. 2019

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Background Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release of heat shock protein, immune function alteration or reduced tissue hypoxia, have been highlighted as possible mechanisms by which increasing physical activity may reduce plasma pro-inflammatory cytokines in uninfected individuals and should be appraised in the literature for evidence of similar benefits in people living with HIV (PLWH). Therefore, we evaluated the effects of physical exercises on 1) inflammatory biomarkers and 2) cardiopulmonary function (VO 2 Max) in PLWH. Method A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to January 2018. Only randomized control trials investigating the effects of either aerobic or resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted with random effect models using the Review Manager (RevMan) computer software. Result Twenty-three studies met inclusion criteria ( n = 1073 participants at study completion) comprising male and female with age range 18–65 years. Three meta-analyses across three sub-groups comparisons were performed. The result showed no significant change in biomarkers of inflammation (IL-6 and IL-1β) unlike a significant (Z = 3.80, p < 0.0001) improvement in VO 2 Max. Overall, the GRADE evidence for this review was of moderate quality. Conclusion There was evidence that engaging in either aerobic or resistance exercise, or a combination of both exercises, two to five times per week can lead to a significant improvement in cardiopulmonary function but not biomarkers of inflammation (IL-6 and IL-1β). However, this should not be interpreted as “No evidence of effect” because the individual trial studies did not attain sufficient power to detect treatment effects. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate. Electronic supplementary material The online version of this article (10.1186/s12879-019-3960-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

et al. 2019

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“…O programa oferecido nesse projeto proporcionou melhorias na composição corporal 22 , na citocinas circulantes 23 e na atividade autonômica, como a variabilidade da frequência cardíaca entre os participantes 11 , o que mostra a grande importância de programas como esse de serem oferecidos a essa população. No entanto, não se pode esquecer uma dimensão importante que é a manutenção dessas pessoas na prática de atividade física, e nesse sentido, os dados do presente estudo podem ser importantes para o planejamento de ações futuras.…”

Section: Discussionunclassified

Adesão e aderência a um programa de exercício físico em pessoas vivendo com HIV/AIDS

Oliveira

Guariglia

Loch

2018

Rev Bras Ativ Fís Saúde

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O objetivo do estudo foi identificar barreiras percebidas à prática de atividade física antes e após participarem de um programa de exercícios físicos (EF), bem como aspectos ligados à adesão e a aderência à este programa, em pessoas vivendo com HIV/aids, especificamente: motivos referidos para faltas as sessões, número de desistências ao longo do programa, continuidade de prática após seis meses ao término do programa e motivos para eventuais não continuidades. Dezenove sujeitos participaram de 14 semanas de um programa de EF. Foram coletadas informações sobre barreiras percebidas para a prática de atividade física, os motivos de faltas ou desistência e a continuidade após seis meses ao término do programa. Para análise dos dados utilizou-se estatística descritiva, o teste de McNemar para verificar as diferenças nas frequências de cada barreira, e de Wilcoxon para comparar o número médio de barreiras no momento pré e pós programa. A média de assiduidade às sessões foi de 58,5% e os principais motivos relatados para as faltas foram “problemas de saúde” e “compromissos pessoais”. Cerca de 40% das pessoas que iniciaram o programa não chegaram até o final do mesmo. A maior parte das desistências aconteceu entre a 11a e a 20a sessão. Não houve diferenças significativas nas barreiras referidas pré e pós programa, nem no número médio de barreiras. Somente 21% dos sujeitos referiram estar praticando EF após seis meses. Programas de EF devem considerar estes achados e buscar elaborar ações mais sustentáveis e de maior impacto a longo prazo na saúde dos sujeitos.

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Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens

Xiang

Chen

Zhang

et al. 2021

Sci. China Life Sci.

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Exercise improves cytokine profile in HIV-infected people: A randomized clinical trial

Cited by 17 publications

References 39 publications

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

Adesão e aderência a um programa de exercício físico em pessoas vivendo com HIV/AIDS

Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens

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