Exercise endurance and fuel utilization: a reevaluation of the effects of fasting

Koubi, Harry; Desplanches, Dominique; Gabrielle, C; Cottet-Émard, J. M.; Semporé, B.; Favier, R.

doi:10.1152/jappl.1991.70.3.1337

Cited by 51 publications

(33 citation statements)

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“…The increased running distance with continued exercise, and the augmentation of this increase by EODF confirmed previous findings (Koubi et al, 1991;Pirke et al, 1993). Muscle contraction during exercise induces a cascade of cardiovascular and muscoskeletal adaptations resulting in improved delivery and utilization of oxygen and nutrients in the working muscles (Taivassalo et al, 2000), thus, enhancing exercise endurance (Kubukeli et al, 2002).…”

Section: Discussionsupporting

confidence: 86%

“…Previous findings showed that EODF induces hyperactivity in rats (Koubi et al, 1991;Pirke et al, 1993). In our experi-…”

Section: Effect Of Eodf And/or Voluntary Exercise On Physical Activitysupporting

confidence: 60%

“…Data shows that the increase in hippocampal neurogenesis following DR paradigms might involve BDNF signaling pathway (Lee et al, 2002;Hubka, 2006). Interestingly, EODF induces hyperactivity in rodents given access to running wheels (Koubi et al, 1991;Pirke et al, 1993), suggesting simultaneous effect on cognitive functions and BDNF activity. Despite the beneficial effect of either voluntary exercise or EODF alone, no studies examined changes in cognitive functions following concurrent exercise and EODF treatments.…”

Section: Introductionmentioning

confidence: 99%

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Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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Substantial data suggest that cognitive function can be influenced by many lifestyle activities associated with changes in energy metabolism such as exercise and diet. In the current study, we investigated the combined effects of voluntary exercise (access to running wheels) and dietary restriction (every other day fasting, EODF) on spatial memory formation and on the levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of Wistar male rats. Spatial learning and memory formation was assessed using the radial arm water maze (RAWM) paradigm, while BDNF protein was measured using ELISA test. Voluntary exercise and/or EODF were instituted for 6 weeks. Voluntary exercise alone significantly enhanced short-term, intermediate-term, and long-term memory formation, and increased BDNF protein levels in the hippocampus. EODF enhanced mean running wheel activity by approximately twofold. However, EODF did not modulate the effects of exercise on memory formation and expression of BDNF. In addition, EODF alone had no effect on memory and BDNF protein in the hippocampus. In conclusion, results of this study indicate that exercise enhanced while EODF had neutral effect on both spatial memory formation and hippocampus BDNF levels.

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Section: Discussionsupporting

confidence: 86%

“…Previous findings showed that EODF induces hyperactivity in rats (Koubi et al, 1991;Pirke et al, 1993). In our experi-…”

Section: Effect Of Eodf And/or Voluntary Exercise On Physical Activitysupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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“…A small portion (20-30 mg) of muscle or liver sample was hydrolyzed in KOH for measurement of glycogen by a method derived from Keppler and Decker 13 Catecholamines were extracted from plasma and assayed by high-pressure liquid chromatography with electrochemical detection as described previously. 14 …”

Section: Analytic Methodsmentioning

confidence: 99%

Metabolic and hormonal responses to exercise in the anti-obese Lou/C rats

et al. 2004

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OBJECTIVE: Lou/C rats are a substrain of Wistar rats that exhibit a spontaneous low caloric intake and no development of obesity with age. Recently, we reported that Lou/C rats, compared to equally food-restricted Wistar counterparts, show lower resting levels of plasma glucose, epinephrine and liver glycogen. To further explore this metabolic particularity, we used exercise (swimming 60 min) as a situation of high-energy demand, to test the ability of Lou/C rats to maintain euglycemia. DESIGN: Male Lou/C rats (14-week-old) were compared to age-matched male Wistar rats fed either ad libitum (WAL) or Wistar rats whose food was chronically restricted (WFR) to the same caloric intake as the Lou/C rats. RESULTS: In spite of low liver glycogen stores (B50% of normal values), Lou/C rats were able to maintain euglycemia during exercise even though liver glycogen breakdown was blunted. The decreased use of glycogen during exercise in Lou/C rats was associated with a reduced epinephrine response compared to WFR animals. By contrast, WFR were also able to maintain euglycemia during exercise but at the expense of a significant (Po0.01) decrease in liver and muscle glycogen content. Plasma free fatty acid and glycerol concentrations were increased (Po0.01) similarly in all three groups during exercise. In a separate experiment conducted in isolated hepatocytes from 24 h fasted Lou/C and Wistar rats, it was found that gluconeogenic flux from glycerol was found to be significantly (Po0.01) higher in Lou/C than in Wistar rats (5.470.2 vs 3.770.1 mmol/min/g dry cells). Resting and exercising plasma leptin levels were also significantly (Po0.05) lower in Lou/C than in the two other groups. CONCLUSION: It is concluded that Lou/C rats have the particularity to rely spontaneously less on their liver glycogen stores to meet their energy demands during exercise while maintaining euglycemia.

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“…Plasma insulin was determined by radio immuno assay (RIA) using a speci®c kit (CIS bio international, Oris industries SA). Plasma levels of adrenaline and noradrenaline were evaluated by high-performance liquid chromatography, following the method of Koubi et al (1991). Plasma 17-û oestradiol was measured by RIA using the ESTR-CTRIA kit (CIS bio International).…”

Section: Blood Measurementsmentioning

confidence: 99%

Effects of glucose ingestion at the onset of moderate-intensity, prolonged exercise in women as compared to men

et al. 2000

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To test glucose tolerance during exercise, the effects of oral glucose ingestion (0.5 g x kg(-1)) on plasma glucose and hormonal responses (insulin, catecholamines) were investigated in 11 women [mean (SEM) age 21.6 (1.3) years] and 10 men [22.0 (0.3) years] during cycle ergometer exercise (30 min at 60% maximum oxygen consumption, VO(2max)). The two groups exhibited similar VO(2max) values, when expressed per kg of lean body mass. Venous blood samples (5 ml) were withdrawn immediately before the exercise, during the exercise (at 3, 5, 10, 15 and 30 min) and at the 30th min of the recovery period. Glucose was ingested orally between the 2nd and the 3rd min of the exercise. As compared to men, plasma glucose concentrations were lower in women during exercise (P < 0.05 at 3, 15 and 30 min) and at the 30th min of the recovery period (P < 0. 001), while plasma insulin concentrations were higher in women during exercise (P < 0.05 at 3, 15 and 30 min). The ratio of the area under the curve for glucose over the area under the curve for insulin was lower in women during exercise (P < 0.0002). A linear relationship between glucose and insulin concentrations was found only for women during exercise (r = 0.615, P < 0.0001). No gender difference was observed for the catecholamine concentration during exercise. In conclusion, this study postulates that an oral glucose load given at the onset of a prolonged and moderate exercise bout induced lesser plasma glucose and greater insulin concentrations in women as compared to men. These data argue in favour of a greater glucose tolerance in women during exercise.

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Exercise endurance and fuel utilization: a reevaluation of the effects of fasting

Cited by 51 publications

References 0 publications

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Metabolic and hormonal responses to exercise in the anti-obese Lou/C rats

Effects of glucose ingestion at the onset of moderate-intensity, prolonged exercise in women as compared to men

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