Excited-state intramolecular proton transfer (ESIPT)-based fluorescent probes for biomarker detection: design, mechanism, and application

Abstract

Biomarkers are essential in biology, physiology, and pharmacology, thus their detection is of extensive importance. Fluorescent probes provide effective tools for the detection of biomarkers exactly. Excited state intramolecular proton...

AIEE Active Azomethine-Based Rhodamine Derivative For Ultrasensitive Multichannel Detection of Au3+ Through a Fluorimetrically, Electrochemically, and RGB-Based Sensing Assay

“…In addition to their remarkable catalytic feature, researchers have shown a significant degree of interest in gold species owing to their high bioactivity at appropriate levels . Several disorders, such as rheumatoid arthritis, cancer, asthma, and HIV, have been commonly treated with gold-based medications. − Moreover, the deposition of larger amounts of gold species (particularly its ionic form Au 3+ ) may cause health risks in creatures like fish, water fleas, fairy shrimp, flukes, and green algae because of their potential interactions with biomolecules like enzymes and DNA. , There are multiple reports of 200 μM AuCl 3 ingestion causing harm to major human organs, including the kidney, liver, and central nervous system. − …”

Pattern Recognition and Visual Detection of Aldehydes Using a Single ESIPT Dye

“…To be more specific, there is a significant fluorescence response of BS1 in the presence of FA under acidic conditions, and the response is less important at higher pH values (Figure S8). Since, of the molecules BS1 – BS3, only BS1 incorporates an intramolecular hydrogen-bonding interaction between its amino NH and benzothiazole N, which should lead to an excited-state intramolecular proton transfer (ESIPT) process, it is possible that the ESIPT process is responsible for the fluorescence response of BS1 in the presence of FA. − This possibility urged us to further investigate the detailed reaction mechanism between BS1 and FA.…”

Circularly polarized luminescence of natural products lycorine and narciclasine: role of excited-state intramolecular proton-transfer and test of pH sensitivity

“…62,63 ESIPT was first hypothesized in 1955 64 to interpret methyl salicylate spectroscopic data and its role has since been recognized in many molecular systems through experiments and calculations. [65][66][67][68][69][70] The phenomenon and the correspondingly observed spectroscopic signature show strong dependence on the strength of the intramolecular H-bonding and on solvent interactions; even the possible occurrence of intermolecular proton transfer has been observed. 62 For this reason, one may expect different results in different solvents.…”