Excitatory Factors in Ventricular Tachycardia Resulting from Myocardial Ischemia. Potassium a Major Excitant

Harris, Andrew; Bisteni, A; Russell, Raymond A.; Brigham, John C.; Firestone, John E.

doi:10.1126/science.119.3085.200

Cited by 272 publications

(69 citation statements)

References 7 publications

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“…The relevance of the potassium ion to the occurrence of lethal ventricular arhythmias soon after the production of acute myocardial ischaemia has been the subject of a number of experimental studies. Some authors have deduced a causal relationship between cumulative potassium loss and the incidence of ventricular arrhythmias in the early stages of experimental myocardial infarction (Harris, Bisteni, Russell, Brigham & Firestone, 1954;Regan, Harman, Lehan, Burke & Oldewurtel, 1967) while others have failed to show any relationship (Wexler & Patt, 1960;Thomas et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Marshall

Parratt

1975

British J Pharmacology

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1The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (1-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG600 1, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Marshall

Parratt

1975

British J Pharmacology

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“…Increased extracellular K+, has been considered to be a major factor in the production of electrical changes in ischaemia (Harris et al 1954;Soloff et al 1960;Ettinger et al 1973;Kaplinsky et al 1979). …”

Section: Discussionmentioning

confidence: 99%

“…The accumulation of extracellular K+ has been implicated in the production of the early electrophysiological changes induced by acute myocardial ischaemia (Harris, Bisteni, Russel, Brigham & Firestone, 1954; Soloff, De los Santos & Oppenheimer, 1960;Ettinger, Regan, Oldewurtel & Khan, 1973; Kaplinsky, Ogawa, Balke & Dreifus, 1979). Studies employing K+-sensitive electrodes have shown Intracavitary recordings of the paced endocardial evoked response and monophasic action potentials are sensitive indices of the electrophysiological changes produced by regional myocardial ischaemia (Donaldson, Taggart, Nashat, Abed, Rickards & Noble, 1983).…”

Section: Introductionmentioning

confidence: 99%

Differential effects of ischaemia and hyperkalaemia on myocardial repolarization and conduction times in the dog.

Donaldson¹,

Nashat²,

Noble³

et al. 1984

The Journal of Physiology

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SUMMARY1. The role of increased extracellular K+ concentration ([K+]O) in the production of the early electrophysiological changes induced by myocardial ischaemia, was evaluated by recordings of monophasic action potentials and the paced endocardial evoked response.2. Changes in the duration of local repolarization and conduction time were evaluated during ischaemia, K+ infusion and hypoxia. 7. Absolute reduction in repolarization time during K+ infusion was more marked at the apex than at the base in the epicardial recordings.8. The superimposition of hypoxia on hyperkalaemia resulted in marked slowing of repolarization and conduction time.9. Many but not all of the early electrophysiological abnormalities of acute ischaemia in the intact heart can be related to raised [K+]O.

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“…The mean starting concentration was 4.8 + 0.5 mM. The electrodes were classified in three groups: (1) [ Figure 4 shows data from one of three similar experiments. Panel b shows a potassium distribution map of ischemia in the LAD area after occlusion combined with high-K perfusion of the remainder of the heart.…”

Section: Laboratory Investigation-myocardial Ischemiamentioning

confidence: 99%

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

et al. 1988

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An experimental approach is described to quantitate inhomogeneity in extracellular K concentration ([Ks ]out) in the presence of ischemia and to relate this inhomogeneity to the electrophysiologic changes. Extracellular potassium concentration and local direct-current electrograms from the same sites were measured in isolated perfused pig hearts with the use of multiple electrodes.Dispersion of [K' lout is described under three conditions: (1) during regional ischemia in the "central zone" and the "borderzone," (2) during global ischemia, and (3)

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Excitatory Factors in Ventricular Tachycardia Resulting from Myocardial Ischemia. Potassium a Major Excitant

Cited by 272 publications

References 7 publications

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Differential effects of ischaemia and hyperkalaemia on myocardial repolarization and conduction times in the dog.

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

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