Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies

Archibald, Jessica; MacMillan, Erin L.; Enzler, Alinda; Jutzeler, Catherine R.; Schweinhardt, Petra; Kramer, John L.K.

doi:10.1016/j.neuroimage.2020.116794

Cited by 15 publications

(14 citation statements)

References 70 publications

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“…Our hypotheses regarding stress and mPFC glutamate were primarily informed on the basis of preclinical studies that were able to measure synaptic glutamate and post-synaptic excitatory currents, while MRS glutamate signal is primarily driven by intracellular glutamate and cannot be used to make direct inferences about glutamate transmission or synaptic release. Despite this limitation, prior fMRS studies and metaanalyses suggest that pain or stressful stimuli can induce reliable changes in MRS metabolites that are consistent with expected changes based on preclinical studies 29,31,51 . Our acute stress manipulation did evoke a significant increase in glutamate for healthy individuals with low levels of recent perceived stress.…”

Section: Discussionmentioning

confidence: 99%

“…Here, we examine changes in glutamate following an acute stressor and how these changes relate to perceived stress using magnetic resonance spectroscopy (MRS), a method that has been widely used to examine in vivo changes in glutamatergic metabolites [29][30][31] . We first examine glutamate metabolites in a sample of healthy adults with varying levels of recent perceived stress before and after an acute stressor that was designed to be unpredictable, minimally controllable, and include a social threat component.…”

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confidence: 99%

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Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

et al. 2021

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Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy control samples and a third sample of unmedicated participants with MDD who completed the Maastricht acute stress task, and one sample of healthy control participants who completed a no-stress control manipulation. In healthy controls, we find that the magnitude of mPFC glutamate response to the acute stressor decreases as individual levels of perceived stress increase. This adaptative glutamate response is absent in individuals with MDD and is associated with pessimistic expectations during a 1-month follow-up period. Together, this work shows evidence for glutamatergic adaptation to stress that is significantly disrupted in MDD.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

et al. 2021

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“…Due to the heterogeneity of the study designs, it was not possible to use the pre-existing quality assessment tools. Thus, according to the categories considered relevant by the authors, the risk of bias (ROB) for the included studies was assessed based on the combination of quality assessment measures suggested in the Cochrane Handbook (Higgins et al, 2019) and categories used in the recent systematic review articles on MRS or on tDCS (Archibald et al, 2020;Shiozawa et al, 2014) Cramer Rao lower bounds [CRLB]) and (j) clearly reported outcome.…”

Section: Risk Of Biasmentioning

confidence: 99%

Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review

Choi

Iordanishvili

Shah

et al. 2021

Human Brain Mapping

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A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable approach enabling the modulation of neuronal excitability and energy in humans is to stimulate the brain using transcranial direct current stimulation (tDCS) and then to observe the effect on neurometabolites using magnetic resonance spectroscopy (MRS). In this way, a well-defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region. This systematic review was guided by the preferred reporting items for systematic reviews and meta-analysis and summarises recent literature studying the effect of tDCS on neurometabolites in the human brain as measured by proton or phosphorus MRS. Limitations and recommendations are discussed for future research. The findings of this review provide clear evidence for the potential of using tDCS and MRS to examine and understand the effect of neurometabolites in the in vivo human brain.

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“…The amino acid transmitter glutamate is the main excitatory neurotransmitter in the brain [122]. Glutamate plays a key role in pain perception, and functional imaging studies have demonstrated elevated levels of glutamate in patients with chronic pain syndromes [123,124]. Glutamate also interacts with opioid receptor functioning, particularly with the µ-opioid receptor, to influence sensitivity to pain [125].…”

Section: E3 Glutamate Receptor Antagonistsmentioning

confidence: 99%

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

Rajkumar¹

2022

Preprint

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Suicidal behaviour is a public health problem whose magnitude is both substantial and increasing. Since many individuals seek medical treatment following a suicide attempt, strategies aimed at reducing further attempts in this population are a valid and feasible secondary prevention approach. An evaluation of the available evidence suggests that existing treatment approaches have limited efficacy in this setting, highlighting the need for innovative approaches to suicide prevention. Existing research on the neurobiology of social pain has highlighted the importance of this phenomenon as a risk factor for suicide, and has also yielded several attractive targets for pharmacological preventive strategies. In this paper, the available evidence related to these targets is synthesized and critically evaluated. The way in which social pain is related to the “anti-suicidal” properties of recently approved treatments, such as ketamine and psilocybin, is also examined. Such strategies may be effective for the short-term reduction of suicidal ideation and behaviour in individuals who have made a suicide attempt suicide prevention, particularly in cases where social pain is identified as a contributory factor. These pharmacological approaches may be effective regardless of the presence or absence of a specific psychiatric diagnosis.

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Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies

Cited by 15 publications

References 70 publications

Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

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