Exazerbation eines Morbus Hailey-Hailey durch Infektion mit Herpes-simplex-Virus Nachweis mittels Polymerasekettenreaktion

Schirren, Hella; Schirren, Carl Georg; Schlüpen, Eva-Maria; Volkenandt, Matthias; Kind, Peter

doi:10.1007/s001050050289

Cited by 22 publications

(4 citation statements)

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“…Dies können unter anderem Dyskeratosis follicularis Darier [22], Pemphigus foliaceus [37], Mycosis fungoides [38], Sezary-Syndrom [8], Ichthyosis vulgaris [62], Pemphigus benignus familiaris Hailey-Hailey [55], Verbrennungen [1,42] und natürlich am häufigsten das atopische Ekzem sein. Zusätzlich werden mit "Kaposi's varizelliforme Eruption" auch Infektionen durch verschiedene andere Viren, wie beispielsweise Kuh-oder Katzenpockenviren, bezeichnet [3,66].…”

Section: Aktuelle Definitionenunclassified

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Eczema herpeticatum

Wetzel

Wollenberg

2004

Hautarzt

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Patients affected by atopic dermatitis tend to develop viral infections. Probably the most feared complication of atopic dermatitis is eczema herpeticum, a disseminated infection with herpes simplex virus. A monomorphic eruption of dome-shaped blisters, pustules and erosions in the eczematous skin lesions along with severe systemic illness leads to the diagnosis. The clinical diagnosis may be confirmed by polymerase chain reaction, viral culture, electron microscopy with negative staining, Tzanck test, immunofluorescence tests or serology. While intravenous acyclovir is still regarded as standard treatment of eczema herpeticum, several recently-developed antiviral drugs provide therapeutic options.

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Section: Aktuelle Definitionenunclassified

“…Die PCR weist hochsensitiv die Anwesenheit von HSV-DNA nach, kann zwischen HSV-1 und HSV-2 unterscheiden und ist auch ohne intakte Bläschen durchführbar [55]. Vorteil der Viruskultur ist die Bestätigung einer manifesten Virusinfektion durch den Nachweis aktiver Virionen.…”

Section: Diagnostikunclassified

Eczema herpeticatum

Wetzel

Wollenberg

2004

Hautarzt

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“…Analogously, 5 lal of the same suspension was used as template for the amplification of a 92-bp fragment of the gene encoding for a HSV-specific DNA polymerase as described previously [13] under the same amplification conditions. Primer sequences were used as described by Cao et al [14].…”

Section: Molecular Detection Of Vzvmentioning

confidence: 99%

Molecular evidence for the existence of disseminated zoster as a distinct entity in an immunosuppressed renal transplant patient

Schlüpen

Nachbar

et al. 1995

J Mol Med

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Immunosuppressed renal transplant recipient are at substantially increased risk for the development of varicella zoster virus infections. They are also more prone than immunocompetent patients to develop atypical zoster and to experience a protracted course, and among them there is a higher frequency of generalized infections with possible fatal outcome. While establishing the diagnosis is essential to provide adequate therapy, conventional laboratory methods frequently fail to confirm the suspected infection. We report on a 47-year-old renal transplant recipient who developed multiple necrotic cutaneous ulcers under immunosuppressive treatment. While electron-microscopic analysis (negative staining) revealed no viral structures, varicella zoster virus specific DNA was detected by polymerase chain reaction in material obtained by a swab from these ulcers. Atypical herpetic infection should also be considered as a cause of disseminated ulcerative or necrotic skin lesions in immunosuppressed patients. Assays based on polymerase chain reaction are useful for the rapid confirmation or rejection of the suspected diagnosis of atypical herpetic infection.

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“…Hailey–Hailey disease is a condition marked by chronic recalcitrant skin lesions localized mainly to flexural areas of the body 2 . Exacerbation of the disease can be induced by infections with Candida albicans , 4 herpes simplex virus, 5,6 pyogenic bacteria, 7 by contact sensitivity and allergy patch testing, 6,8 ultraviolet B radiation 9 and mechanical trauma 8 …”

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confidence: 99%