Examining the relationship between brominated flame retardants (BFR) exposure and changes of thyroid hormone levels around e-waste dismantling sites

Wang, Hongmei; Yuan, Zhongwei; Liu, Qian; Wang, Feifei; Nie, Jing; Qian, Yan

doi:10.1016/j.ijheh.2010.06.004

Cited by 65 publications

(49 citation statements)

References 74 publications

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“…This study finds out that when the house functions as an e-waste recycling workshop negatively associate with FT4 of children, suggests that living in an ewaste dismantling area or in a family-run informal e-waste workshop might cause changes in thyroid hormones, a conclusion differing from prior studies. Exposure to brominated flame retardants released from informal e-waste handling might result in changes in THs and TSH levels [60], whereas in that study, the TSH levels in the e-waste recycling occupational-exposed groups were lower than that in the non-occupational-exposed group. These results are consistent with several studies that found PBDEs were negatively associated with TSH [61][62][63].…”

Section: Discussioncontrasting

confidence: 63%

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

Liu¹

2012

Sixth International Conference on Environmental Mutagens in Human Populations

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Informal electronic waste (e-waste) recycling results in serious environmental pollution of polybrominated diphenyl ethers (PBDEs) and heavy metals. This study explored whether there is an association between PBDEs, heavy metal and key growth-and development-related hormones in children from Guiyu, an e-waste area in southern China. We quantified eight PBDE congeners using gas chromatographic mass spectrometry, lead and cadmium utilizing graphite furnace atomic absorption spectrometry, three thyroids with radioimmunoassay and two types of growth hormones by an enzyme-linked immune-sorbent assay (ELISA) in 162 children, 4 to 6 years old, from Guiyu. In blood, median total PBDE was 189.99 ng/g lipid. Lead and cadmium concentrations in blood averaged 14.53¡4.85 mg dL 21 and 0.77¡0.35 mg L 21 , respectively. Spearman partial correlation analysis illustrated that lead was positively correlated with BDE153 and BDE183. Thyroid-stimulating hormone (TSH) was positively correlated with almost all PBDE congeners and negatively correlated with insulin-like growth factor binding protein-3 (IGFBP-3), whereas free triiodothyronine (FT3) and free thyroxine (FT4) were negatively correlated with BDE154. However, no correlation between the hormones and blood lead or cadmium levels was found in this study. Adjusted multiple linear regression analysis showed that total PBDEs was negatively associated with FT3 and positively associated with TSH. Notably, FT4 was positively correlated with FT3, house functions as a workshop, and father's work involved in e-waste recycling and negatively correlated with vitamin consumptions.

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Section: Discussioncontrasting

confidence: 63%

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

Liu¹

2012

Sixth International Conference on Environmental Mutagens in Human Populations

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“…Significant associations between adverse birth outcomes including stillbirth, low birth weight, and premature delivery with PBDE concentrations were observed in Guiyu, a notorious e-waste recycling site in China (Wu et al, 2010a). Most epidemiological studies also suggested an association between PBDEs with clinical or subclinical hyperthyroidism (Chevrier et al, 2010;Wang et al, 2010), and with neuropsychological functioning, e.g., motor, cognitive and behavioral performance, and mental and physical development in children (Gascon et al, 2011;Herbstman et al, 2010;Roze et al, 2009). The potential adverse effects of the HFRs to the local residents in the present e-waste recycling sites still remain unknown.…”

Section: Estimated Daily Intake Of Hfrs Via the Eggsmentioning

confidence: 99%

Halogenated flame retardants in home-produced eggs from an electronic waste recycling region in South China: Levels, composition profiles, and human dietary exposure assessment

Zheng

Luo

et al. 2012

Environment International

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“…Four studies examined the association between e-waste exposure on workers and health outcomes, such as thyroid function [34][35][36] or DNA oxidative damage markers (micronucleated binucleated cells in peripheral blood or 8-OHdG) 31,36 .…”

Section: Resultsmentioning

confidence: 99%

“…Wang H. 35 reports decreased concentrations associated with e-waste exposure. Nevertheless, Han G and Yuan 34,36 reports increased concentrations in the exposed population.…”

Section: Paula Lechuga Vázquez Mª Luisa Paredes Rizomentioning

confidence: 99%

Efectos biológicos derivados de la exposición a PBDES en trabajadores del reciclaje de e-waste: revisión sistemática

Vázquez

Rizo

2014

Med. segur. trab.

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MEDICINA y SEGURIDAD del trabajo Octubre -diciembre 2014 Med Segur Trab (Internet) 2014 60 (237) AbstractIntroduction: PBDEs are potentially dangerous substances released during the e-waste recycling processes. Scientific evidence relates PBDEs with adverse health outcomes like cancer, endocrine disruptions and problems in the offspring. A high concentration of PBDEs has been found on biological samples (serum, hair, breast milk and umbilical cord) from exposed workers, so their exposure could imply a potential risk on workers health. Aim:To summarize the evidence between exposure to PBDEs contained in e-waste and adverse health outcomes on recycling industry workers. Materials and methods:A systematic review was done among the scientific literature published between 2003 and 2013 in seven data bases using Medical Subject Headings (MeSH) terms.Results: 301 articles were evaluated and 20 were included in the review. 65% were from China, 80% had a cross-sectional design. We assessed evidence of association between exposure to e-waste and levels of PBDEs in several biological samples. Workers showed high levels in the DNA damage markers. The effects from the exposure to PBDEs on the thyroid function were not consistent. Conclusions:Findings from most studies shows a correlation between the exposure to PBDEs and the alteration of the biological parameters on the recycling industry workers, but our ability to assess temporality associations was limited by the small number of prospective and longitudinal studies. Conventional industrial hygiene improvements in e-waste recycling facilities may reduce the exposure on workers to PBDEs. Med Segur Trab (Internet) 2014; 60 (237) 714-741Key words: PBDEs, e-waste, occupational exposure. ResumenIntroducción: Los PBDEs son sustancias potencialmente peligrosas liberadas del reciclaje de e-waste. La evidencia científica implica a los PBDEs en alteraciones en la salud como cáncer, alteraciones endocrinas y problemas en la descendencia. Se han encontrado elevadas concentraciones en muestras biológicas (suero, pelo, leche materna y cordón umbilical) de los trabajadores expuestos, por lo que su exposición implicaría un potencial riesgo para la salud para los trabajadores y su descendencia.Objetivo: Identificar la evidencia existente entre exposición a PBDEs contenidos en e-waste y los daños sobre la salud en trabajadores de la industria del reciclaje. Material y métodos:Se realizó una revisión sistemática de la literatura científica publicada entre 2003 y 2013, en siete bases de datos mediante términos MeSH. Las referencias se cribaron en función de los objetivos.Resultados: Se recuperaron 301 artículos y se incluyeron en la revisión 20. El 65% fueron realizados en China, el 80% respondían a un diseño transversal. Los estudios evidencian una asociación entre exposición a PBDEs y los niveles de PBDEs en distintas muestras biológicas. Los trabajadores presentaron mayores niveles de marcadores de daño al DNA. Los efectos de la exposición a PBDEs sobre la función tiroidea no fueron ...

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Examining the relationship between brominated flame retardants (BFR) exposure and changes of thyroid hormone levels around e-waste dismantling sites

Cited by 65 publications

References 74 publications

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

Halogenated flame retardants in home-produced eggs from an electronic waste recycling region in South China: Levels, composition profiles, and human dietary exposure assessment

Efectos biológicos derivados de la exposición a PBDES en trabajadores del reciclaje de e-waste: revisión sistemática

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