Examining the Potential for South American Arboviruses to Spread Beyond the New World

Peña-García, Víctor Hugo; McCracken, Michael K.; Christofferson, Rebecca C.

doi:10.1007/s40588-017-0076-4

Cited by 8 publications

(7 citation statements)

References 103 publications

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“…These pressures are a major driver of new zoonotic pathogens that are able to cross from one species to another. For example, expansion of the geographic range of the arthropod vectors had a considerable effect on the spread of arboviruses (Pena-Garcia, McCracken and Christofferson 2017 ; Sukhralia et al . 2019 ).…”

Section: Modern Vaccinologymentioning

confidence: 99%

Development of vaccines at the time of COVID-19

et al. 2020

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In December 2019, a working group of the European Academy of Microbiology assembled to discuss various aspects of vaccines and vaccinations. The meeting was organised by Jörg Hacker and Eliora Z. Ron and took place in the offices of the Leopoldina (German National Academy of Sciences Leopoldina). Several important issues were addressed and a major part of the discussion focused on the need to develop new vaccines, especially to protect against pathogens that constitute a pandemic threat. Following the rapid and unpredicted spread of COVID-19 in the first seven months of 2020, the need to develop vaccines for pandemic viruses rapidly has been clearly established. Thus, this paper will concentrate on points that were highlighted by the recent COVID-19 pandemic and lessons learnt therefrom.

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Section: Modern Vaccinologymentioning

confidence: 99%

Development of vaccines at the time of COVID-19

et al. 2020

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“…As many of them are the etiological agents of relevant human pathologies, they pose a special threat in vulnerable countries around the world. Tropical countries of South America, such as Brazil, are specially in risk for arboviruses outbreaks due to the suitable warm weather, abundance of insect vectors, deforestation, high population concentration near forest areas, social-economical disparities, and overburden of the public healthcare system ( Peña-García et al., 2017 ; Figueiredo, 2019 ; Medeiros and Vasconcelos, 2019 ). Many endemic outbreaks along the history, as well the recent introduction of arboviruses in Brazil, have risen the alarm of scientific and medical communities concerning the risk of new outbreaks, co-circulation of those viruses, and increasing of more severe cases ( Metsky et al., 2017 ; Zanotto and Leite, 2018 ; Lorenz et al., 2019 ; Gutierrez et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

Geddes

Brustolini

Cavalcante

et al. 2021

Front. Cell. Infect. Microbiol.

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Arboviruses pose a major threat throughout the world and represent a great burden in tropical countries of South America. Although generally associated with moderate febrile illness, in more severe cases they can lead to neurological outcomes, such as encephalitis, Guillain-Barré syndrome, and Congenital Syndromes. In this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. Here, we presented a comprehensive genome-wide transcriptome analysis of human primary astrocytes infected with Chikungunya, Mayaro, Oropouche, or Zika viruses. Analyses of differentially expressed genes (DEGs), pathway enrichment, and interactomes have shown that Alphaviruses up-regulated genes related to elastic fiber formation and N-glycosylation of glycoproteins, with down-regulation of cell cycle and DNA stability and chromosome maintenance genes. In contrast, Oropouche virus up-regulated cell cycle and DNA maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. Zika virus infection only up-regulated eukaryotic translation machinery while down-regulated interferon pathways. Reactome and integration analysis revealed a common signature in down-regulation of innate immune response, antiviral response, and inflammatory cytokines associated to interferon pathway for all arboviruses tested. Validation of interferon stimulated genes by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) corroborated our transcriptome findings. Altogether, our results showed a co-evolution in the mechanisms involved in the escape of arboviruses to antiviral immune response mediated by the interferon (IFN) pathway.

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“…Dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) are endemic arboviruses in tropical and subtropical regions of the world. Environmental changes and vector density, along with migration and immigration patterns of people contribute to the dissemination of these viruses and enable the occurrence of outbreaks or epidemics [1]. CHIKV belongs to the family Togaviridae (genus Alphavirus), DENV and ZIKV to the family Flaviviridae (genus Flavivirus).…”

Section: Introductionmentioning

confidence: 99%

Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil

et al. 2021

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Background The co-circulation of types of arbovirus in areas where they are endemic increased the risk of outbreaks and limited the diagnostic methods available. Here, we analyze the epidemiological profile of DENV, CHIKV and ZIKV at the serological and molecular level in patients with suspected infection with these arboviruses in the city of Juazeiro do Norte, Ceará, Brazil. Methods In 2016, the Central Public Health Laboratory (LACEN) of Juazeiro do Norte received 182 plasma samples from patients who visited health facilities with symptoms compatible with arbovirus infection. The LACEN performed serological tests for detection of IgM/IgG to DENV and CHIKV. They then sent these samples to the Retrovirology Laboratory of the Federal University of São Paulo and Faculty of Medical of the ABC where molecular analyses to confirm the infection by DENV, ZIKV and CHIKV were performed. The prevalence of IgM/IgG antibodies and of infections confirmed by RT-qPCR were presented with 95% confidence interval. Results In serologic analysis, 125 samples were positive for antibodies against CHIKV and all were positive for antibodies against DENV. A higher prevalence of IgG against CHIKV (63.20% with 95% CI: 45.76–70.56) than against DENV (95.05% with 95% CI: 78.09–98.12) was observed. When the samples were submitted to analysis by RT-qPCR, we observed the following prevalence: mono-infection by ZIKV of 19.23% (95% CI: 14.29–34.82) patients, mono-infection by CHIKV of 3.84% (95% CI: 2.01–5.44) and co-infection with ZIKV and CHIKV of 1.09% (95% CI: 0.89–4.56). Conclusion The serologic and molecular tests performed in this study were effective in analyzing the epidemiological profile of DENV, CHIKV and ZIKV in patients with suspected infection by these arboviruses in the city of Juazeiro do Norte, Ceará/Brazil.

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Examining the Potential for South American Arboviruses to Spread Beyond the New World

Cited by 8 publications

References 103 publications

Development of vaccines at the time of COVID-19

Development of vaccines at the time of COVID-19

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil

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