Examination of biofilm formation and risk of infection associated with the use of urinary catheters with leg bags

Rogers, J; Norkett, D.I; Bracegirdle, P.; Dowsett, A. B.; Walker, James T.; Brooks, Timothy; Keevil, C. W.

doi:10.1016/s0195-6701(96)90052-3

Cited by 22 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also describe a novel model of the catheterized lower urinary tract which, unlike previous models [14][15][16][17], includes the urethra. Catheters from this model were cultured using the same method as was used for the patient catheters.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical trials have generally focused on the number of bacteria in the urine [6,10] although a few have used scanning electron microscopy [11] or limited culture to examine the catheters themselves [12,13]. In vitro models of CAUTI have examined bacterial growth on the inside of the catheter and in the urine or in artificial urine [14–17]. No studies have assessed whole‐catheter cultures nor studied microbiological differences between the inside and outside of catheters.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A model of catheter‐associated urinary tract infection initiated by bacterial contamination of the catheter tip

Barford

Anson

et al. 2008

BJU International

View full text Add to dashboard Cite

extracted from selected patient catheter isolates and the DNA fragment of 16S ribosomal RNA was amplified by polymerase chain reaction and confirmed by DNA sequencing. The DNA sequences from the isolates obtained from different catheter sections and from urine in the same patient were compared. RESULTSAfter 1 day of catheterization there was significant bacterial growth on the outside of all the segments of patient catheters; there was significant growth on the inside of all segments by 4 days. Higher viable counts and a wider spectrum of genera were found on the outside than on the inside of these catheters. The same strains of bacteria, as determined by ≥ 98% similarity of the 16S ribosomal DNA sequence, were found on the outside and inside of catheters and in the urine. In the in vitro model, when the distal urethra was inoculated before inserting the catheter, the viable counts after incubation were variable along the outside of the catheter and the inside counts were uniformly high. By contrast, there was a different pattern after inoculating the inside of the distal end of the catheter, leading to an ascending biofilm on the inside. A smaller inoculum delayed but did not prevent infection in the model. CONCLUSIONThe present results are consistent with the hypothesis that contamination of the tip of the catheter while it is being inserted is a possible means by which bacteria gain access to the bladder.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A model of catheter‐associated urinary tract infection initiated by bacterial contamination of the catheter tip

Barford

Anson

et al. 2008

BJU International

View full text Add to dashboard Cite

show abstract

“…Contact with contaminated surfaces or infection by air-borne bacteria or fungal spores places surgical patients at risk [60, 61]. In fact, more than 60% of hospital related complications and up to 80% of infection associated deaths are attributable to biofilm infections [62, 63], and nearly 80% of known pathogenic bacteria have been implicated in device-related infections [64, 65], such as intravenous and urinary catheters [66], joint prostheses [67, 68], penile prostheses [69], contact lenses [70], fracture fixation devices [71, 72], breast implants [73, 74], pacemakers [75], endoscopes [76], cardiovascular and biliary stents [77], and coherent implants [78, 79]. Biofilms on these devices transmit bacteria and act as source of infection.…”

Section: Biofilm Formation and Biofoulingmentioning

confidence: 99%

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

Ramasamy

Lee

2016

BioMed Research International

216

126

View full text Add to dashboard Cite

Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant strains. In this context, recent developments in the material science and engineering fields and steady progress in the nanotechnology field have created opportunities to design new biomaterials and surfaces with anti-infective, antifouling, bactericidal, and antibiofilm properties. Here we review a number of the recently developed nanotechnology-based biomaterials and explain underlying strategies used to make antibiofilm surfaces.

show abstract

“…Bacterial biofilm has been recovered from an increasing number of device-associated infections, including joint prostheses, 30 penile prostheses, 35 fracture fixation devices, 36,37 intravenous 38 and urinary catheters, 39 peritoneal dialysis catheters, 40 contact lenses, 41 breast prostheses, 42,43 endoscopes, 44 cardiovascular 45 and biliary 46 stents, pacemakers, 47 and cochlear implants. 48 The evidence for biofilm as the leading cause of implant failure will be outlined for prosthetic joints, cardiovascular implants, and breast implants, as these have the most relevance to plastic and reconstructive surgeons.…”

Section: Scope Of Device-associated Infectionmentioning

confidence: 99%

The Role of Bacterial Biofilms in Device-Associated Infection

Deva

Adams

Vickery

2013

Plastic and Reconstructive Surgery

221

121

View full text Add to dashboard Cite

There is increasing evidence that bacterial biofilm is responsible for the failure of medical devices, leading to device-associated infection. As plastic surgeons, we are among the leading users of prostheses in surgery, and it is important that we are kept informed of this growing problem. This article summarizes the pathogenesis of device-associated infection, outlines the evidence for such infection in a number of medical devices, and outlines operative strategies aimed at reducing the risk of bacterial contamination at the time of device deployment. It also outlines strategies under investigation to combat the development of device-associated infection.

show abstract

Examination of biofilm formation and risk of infection associated with the use of urinary catheters with leg bags

Cited by 22 publications

References 6 publications

A model of catheter‐associated urinary tract infection initiated by bacterial contamination of the catheter tip

A model of catheter‐associated urinary tract infection initiated by bacterial contamination of the catheter tip

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

The Role of Bacterial Biofilms in Device-Associated Infection

Contact Info

Product

Resources

About