Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology

Forte, Elvira; McLellan, Micheal A.; Skelly, Daniel A.; Rosenthal, Nadia

doi:10.3390/ijms22042071

Cited by 3 publications

(2 citation statements)

References 200 publications

(198 reference statements)

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“…Mouse cardiac cell populations have been extensively reviewed since the rise of single-cell technologies. [60][61][62] While cardiomyocyte studies require special sample preparation due to their size, 63 single-cell analysis of the adult mouse heart has focused mainly on fibroblasts, immune, and vascular cells. 14,[64][65][66] Multiomic approaches are now also highlighting the epigenetic and regulatory differences between the species.…”

Section: Systems: Comparing Mouse and Human Cardiac Cellsmentioning

confidence: 99%

Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics

Palmer,

Rosenthal,

Teichmann

et al. 2024

Circulation Research

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Throughout our lifetime, each beat of the heart requires the coordinated action of multiple cardiac cell types. Understanding cardiac cell biology, its intricate microenvironments, and the mechanisms that govern their function in health and disease are crucial to designing novel therapeutical and behavioral interventions. Recent advances in single-cell and spatial omics technologies have significantly propelled this understanding, offering novel insights into the cellular diversity and function and the complex interactions of cardiac tissue. This review provides a comprehensive overview of the cellular landscape of the heart, bridging the gap between suspension-based and emerging in situ approaches, focusing on the experimental and computational challenges, comparative analyses of mouse and human cardiac systems, and the rising contextualization of cardiac cells within their niches. As we explore the heart at this unprecedented resolution, integrating insights from both mouse and human studies will pave the way for novel diagnostic tools and therapeutic interventions, ultimately improving outcomes for patients with cardiovascular diseases.

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Section: Systems: Comparing Mouse and Human Cardiac Cellsmentioning

confidence: 99%

Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics

Palmer,

Rosenthal,

Teichmann

et al. 2024

Circulation Research

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“…Noteworthily, there are relatively static CFs and no MFs in a healthy heart ( Hall et al, 2021 ). Recent single-cell multi-omics studies have elevated our knowledge of CFs in cardiac fibrosis ( Forte et al, 2021a ). For example, new CFs have been found, presenting as early as 1 day after MI ( Shi et al, 2021 ), which can promote inflammation and recruit leukocytes.…”

Section: Pathophysiology Of Post-mi Cardiac Fibrosismentioning

confidence: 99%

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Yin

Pan

et al. 2023

Front. Pharmacol.

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Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.

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