Evolving Magnetically Levitated Plasma Proteins Detects Opioid Use Disorder as a Model Disease

Ashkarran, Ali Akbar; Olfatbakhsh, Tina; Ramezankhani, Milad; Crist, Richard C.; Berrettini, Wade H.; Milani, Abbas S.; Pakpour, Sepideh

doi:10.1002/adhm.201901608

Cited by 27 publications

(40 citation statements)

References 25 publications

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“…We have recently levitated plasma proteins using superparamagnetic iron oxide nanoparticles and revealed that the levitated plasma proteins create ellipsoidal patterns [238]. Using machine learning and liquid chromatography mass spectroscopy approaches, we then demonstrated that the patterns of the levitated plasma proteins contain useful information regarding the health spectrum of plasma donors [239]. This strategy can be very helpful and feasible for monitoring the interactions between gut microbiota patterns and CAD.…”

Section: Microbiota and Nanomedicine-based Approachesmentioning

confidence: 99%

Gut microbiota and cardiovascular disease: opportunities and challenges

et al. 2020

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Coronary artery disease (CAD) is the most common health problem worldwide and remains the leading cause of morbidity and mortality. Over the past decade, it has become clear that the inhabitants of our gut, the gut microbiota, play a vital role in human metabolism, immunity, and reactions to diseases, including CAD. Although correlations have been shown between CAD and the gut microbiota, demonstration of potential causal relationships is much more complex and challenging. In this review, we will discuss the potential direct and indirect causal roots between gut microbiota and CAD development via microbial metabolites and interaction with the immune system. Uncovering the causal relationship of gut microbiota and CAD development can lead to novel microbiome-based preventative and therapeutic interventions. However, an interdisciplinary approach is required to shed light on gut bacterial-mediated mechanisms (e.g., using advanced nanomedicine technologies and incorporation of demographic factors such as age, sex, and ethnicity) to enable efficacious and high-precision preventative and therapeutic strategies for CAD. Key points The causal relationship between gut microbiota and CAD development has yet to be confirmed. It is imperative to understand the potential direct and indirect causal roots between gut microbiota and CAD development via microbial metabolites and interaction with the immune system. Dynamic elements including our diet and demographic factors such as age, sex, and ethnicity can also affect our gut microbiota and CAD development and complicate this matter. Interdisciplinary approaches are required to shed light on the factors involved in the modulation of gut microbiota and its association with CAD development. Elucidating the system-level multifaceted web of factors involved in microbiome-mediated mechanisms and human health and disease can guide novel preventative and therapeutic interventions for CAD.

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Section: Microbiota and Nanomedicine-based Approachesmentioning

confidence: 99%

Gut microbiota and cardiovascular disease: opportunities and challenges

et al. 2020

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“…59 Specifically, our supervised classification analysis demonstrated proof-of-concept that the movement of levitating proteins in MagLev has disease detection capacity, with potential use in a point-of-care device. 59 More specifically, we found that MagLev optic images of levitated proteins, subjected to machine-learning analysis, offer valuable information on the individual's health status ( Figure 4). 59 In addition, the levitated ellipsoidal patterns of proteins can be separated and analyzed with proteomic approaches to learn more about the role of important proteins in disease development.…”

Section: ■ Biomolecular Coronamentioning

confidence: 90%

“…59 More specifically, we found that MagLev optic images of levitated proteins, subjected to machine-learning analysis, offer valuable information on the individual's health status ( Figure 4). 59 In addition, the levitated ellipsoidal patterns of proteins can be separated and analyzed with proteomic approaches to learn more about the role of important proteins in disease development. 59 Based on these results, the MagLev platform may have the capacity for rapid discrimination of patients at risk of fatal COVID-19 progressive disease (e.g., by exacerbating cardiovascular diseases 3−5 ) and also accelerate the development of biomarker(s) to identify such patients.…”

Section: ■ Biomolecular Coronamentioning

confidence: 96%

“…59 In addition, the levitated ellipsoidal patterns of proteins can be separated and analyzed with proteomic approaches to learn more about the role of important proteins in disease development. 59 Based on these results, the MagLev platform may have the capacity for rapid discrimination of patients at risk of fatal COVID-19 progressive disease (e.g., by exacerbating cardiovascular diseases 3−5 ) and also accelerate the development of biomarker(s) to identify such patients. The use of nonplasma biological fluids (e.g., tear, saliva, and urine) is preferred but will require testing, for the reasons mentioned in the Biomolecular Corona section.…”

Section: ■ Biomolecular Coronamentioning

confidence: 99%

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Emerging Biomolecular Testing to Assess the Risk of Mortality from COVID-19 Infection

Mahmoudi

2020

Mol. Pharmaceutics

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 and COVID-19) has produced an unprecedented global pandemic. Though the death rate from COVID-19 infection is ∼2%, many infected people recover at home. Among patients for whom COVID-19 is deadly are those with pre-existing comorbidities. Therefore, identification of populations at highest risk of COVID-19 mortality could significantly improve the capacity of healthcare providers to take early action and minimize the possibility of overwhelming care centers, which in turn would save many lives. Although several approaches have been used/ developed (or are being developed/suggested) to diagnose COVID-19 infection, no approach is available/proposed for fast diagnosis of COVID-19 infections likely to be fatal. The central aim of this short perspective is to suggest a few possible nanobased technologies (i.e., protein corona sensor array and magnetic levitation) that could discriminate COVID-19-infected people while still in the early stages of infection who are at high risk of death. Such discrimination technologies would not only be useful in protecting health care centers from becoming overwhelmed but would also provide a powerful tool to better control possible future pandemics with a less social and economic burden.

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“…However, oil and some surfactants are inevitably used in the preparation process, as a result, microspheres often lack good biocompatibility. [ 30,31 ] Emulsion method faces the similar problem. This has become the main factor restricting the further development of microfluidic and emulsion technology.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Zhang

Wang

et al. 2020

Macro Materials & Eng

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Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

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Evolving Magnetically Levitated Plasma Proteins Detects Opioid Use Disorder as a Model Disease

Cited by 27 publications

References 25 publications

Gut microbiota and cardiovascular disease: opportunities and challenges

Gut microbiota and cardiovascular disease: opportunities and challenges

Emerging Biomolecular Testing to Assess the Risk of Mortality from COVID-19 Infection

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

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