Evolving Knowledge of Hemangiomas and Vascular Malformations

Eichenfield, Lawrence F.

doi:10.1001/archderm.134.6.740

Cited by 22 publications

(16 citation statements)

References 25 publications

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“…They accelerate during puberty, pregnancy as well as trauma like in our case. 9,10,11 The lesion was present in the buccal mucosa, for years till the trauma triggered it to expand with inflammation and pain.…”

mentioning

confidence: 99%

Intraoral Venous Malformation With Phleboliths – A Case Report With Review of the Literature.

Amin¹,

Hegde²,

Shetty³

et al. 2017

IJAR

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mentioning

confidence: 99%

Intraoral Venous Malformation With Phleboliths – A Case Report With Review of the Literature.

Amin¹,

Hegde²,

Shetty³

et al. 2017

IJAR

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“…(Burrows et al, 1998 (Mulliken, Glowacki, 1982;Mulliken, Young, 1988;Brevière et al, 1999;Breugem et al, 2001). Síndromes malformativas congênitas são mais associadas às malformações vasculares do que aos hemangiomas (Einchenfield, 1998 Não houve nenhum caso de paciente portador de malformação vascular, mesmo que concomitante à presença do hemangioma.…”

Section: Avaliação Do Contorno Facialunclassified

“…São incluídos neste grupo todas as malformações congênitas do sistema vascular, tais como as malformações arteriais, venosas, linfáticas, capilares e suas combinações, os tumores vasculares benignos, como os hemangiomas, hemangioendoteliomas, angiomas em tufos, glomangiomas, granulomas piogênicos e também os tumores vasculares malignos, como os hemangioendoteliossarcomas e os angiossarcomas (Mulliken, Glowacki, 1982;Jackson et al , 1993;Enjolras et al, 1997;Einchenfield, 1998;Drolet et al , 1999, Metry, Herbert, 2000 Por longo período de tempo não houve consenso em relação à terminologia e classificação destas lesões, com impacto negativo nas indicações terapêuticas, muitas vezes aplicadas de forma heterogênea e não parametrizada.…”

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“…Na atualidade, classificações baseadas no aspecto biológico das lesões, são as mais aceitas (Mulliken, Glowacki, 1982;Einchenfield, 1998;Metry, Herbert, 2000;Enjolras et al, 2001 O termo hemangioma foi então definido como uma neoplasia propriamente dita, apresentando proliferação endotelial pré-natal ou pós-natal, crescimento por hiperplasia e hipertrofia celular, com características microscópicas e ultramicroscópicas de tecido neoplásico, sendo facilmente cultivado em culturas celulares (Mulliken, Young, 1988) Os hemangiomas apresentam crescimento acelerado durante a infância e um significativo potencial de regressão espontânea, durante os primeiros anos de vida. Os hemangiomas são os tumores vasculares benignos mais freqüentes dentre todas as lesões vasculares tumorais (Low, 1994;Einchenfield., 1998;Drolet, 1999).…”

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“…Podem adquirir dimensões variadas e apresentarem um comportamento bastante agressivo, na dependência do tipo vascular predominante (Mulliken, Young, 1988;Breugem et al, 2001) Nos últimos anos, diferentes subtipos de tumores vasculares têm sido diagnosticados, baseados nos recentes achados de biologia molecular e estudos genéticos (Enjolras et al, 1997;Cattean et al, 1998;Einchenfield, 1998;Drolet et al, 1999,. Enjolras et al, 2001 A incidência dos hemangiomas cutâneos varia de 2.5 a 5 % em recém-nascidos caucasianos.…”

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Estudo crítico dos resultados obtidos no tratamento dos hemangiomas cutâneos cervicofaciais

Goldenberg¹

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Endothelial cell tumors

Bell

2003

Microscopy Res & Technique

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Historically, there has been much debate on the nature of infantile hemangiomas as either congenital malformations or benign neoplasms. Some vascular lesions that are present at birth and evidence no proliferative growth are considered to be congenital malformations; other post-natal vascular tumors pursue aggressive and possibly lethal clinical courses. The literature of the last two decades has been reviewed with a hope of clarifying the pathogenesis and underlying molecular lesions of this diverse set of lesions. Genetic investigations of two diseases associated with vascular tumors and abnormalities, von Hippel-Lindau disease, and Hereditary Hemorrhagic Telangiectasia have greatly added to our knowledge of vascular proliferation and provided a tantalizing clue to the pathogenesis of hemangioblastomas. Mutations have also been described in infantile hemangiomas. All of the entities considered, vascular neoplasms as well as malformations, have been examined for the expression of vascular growth factors, their receptors, and factors that appear to promote cell proliferation. Similarly, factors that either block or promote apoptosis have also been examined in various vascular lesions. These studies have in large confirmed our expectations about proliferating tumors that show upregulation of growth promoting factors and inhibition of those that promote apoptosis. In conclusion, although much has been learned about vascular physiology and the control of endothelial proliferation, and while understanding about the molecular pathogenesis of the two inherited diseases mentioned above is detailed but not yet complete, understanding of the pathogenesis of benign and malignant endothelial tumors remains vague.

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Evolving Knowledge of Hemangiomas and Vascular Malformations

Cited by 22 publications

References 25 publications

Intraoral Venous Malformation With Phleboliths – A Case Report With Review of the Literature.

Intraoral Venous Malformation With Phleboliths – A Case Report With Review of the Literature.

Estudo crítico dos resultados obtidos no tratamento dos hemangiomas cutâneos cervicofaciais

Endothelial cell tumors

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