Evolving Evidence in Idiopathic Intracranial Hypertension

Mollan, Susan P; Moss, Heather E.; Hamann, Steffen

doi:10.3390/life11111225

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The combined FARB scores revealed a severe degree of cerebral sinus stenosis in both groups (2.5 ± 1.9 in the non-obese group and 2.6 ± 2.1 in the obese group, p = 0.93). Furthermore, when categorizing the binary combined FARB score into high-grade stenosis (1-2) and low-grade stenosis (3)(4)(5)(6)(7)(8), no difference was found. Upon multivariate analysis, scleral flattening was the only variable independently associated with non-obesity (OR 2.4, 95% CI 1.02-5.9. p = 0.004) (Table 4).…”

Section: Resultsmentioning

confidence: 92%

“…Patients may also present without papilledema, given other radiographic findings, such as an empty sella and transverse venous sinus stenosis [ 1 ]. IIH can cause severe headaches and vision loss [ 2 ], and is typically found in obese women of a childbearing age [ 3 , 4 , 5 , 6 ]. Given the association with obesity, weight loss is one of the first treatment recommendations given to patients with IIH [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension

Horev,

Ben-Arie,

Zlotnik

et al. 2024

JCM

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While the typical patient with idiopathic intracranial hypertension (IIH) is an obese female of childbearing age, there are unique patient populations, such as non-obese females, that have not been well studied. Characterizing this subpopulation may increase awareness our of it, which may prevent underdiagnosis and improve our understanding of IIH’s underlying pathophysiology. We retrospectively reviewed electronic medical records and compared the clinical and radiological characteristics of non-obese (BMI < 30) and obese (BMI > 30) female patients with IIH. Two hundred and forty-six patients (age 32.3 ± 10) met our inclusion criteria. The non-obese patients (n = 59, 24%) were significantly younger than the obese patients (29.4 ± 9.9 vs. 33.2 ± 10.2, p = 0.004) and had higher rates of severe papilledema (Friesen 4–5; 25.4% vs. 11.8%, p = 0.019), scleral flattening (62.7% vs. 36.9%, p = 0.008), and optic nerve dural ectasia (78.0% vs. 55.6%, p = 0.044). Non-obese patients also had a tendency to have a higher lumbar puncture opening pressure (368 ± 92.7 vs. 344 ± 76.4, p = 0.062). Non-obese patients were three times more likely to present with a combination of scleral flattening and optic nerve dural ectasia (OR = 3.00, CI: 1.57–5.72, χ2 = 11.63, α < 0.001). Overall, non-obese females with IIH were found to have a more fulminant presentation, typified by higher rates of severe papilledema and radiological findings typical for IIH.

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension

Horev,

Ben-Arie,

Zlotnik

et al. 2024

JCM

View full text Add to dashboard Cite

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The expanding spectrum of idiopathic intracranial hypertension

Biousse

Newman

2022

Eye

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Understanding the pathophysiology of idiopathic intracranial hypertension (IIH): a review of recent developments

Colman,

Boonstra,

Nguyen

et al. 2023

J Neurol Neurosurg Psychiatry

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Idiopathic intracranial hypertension (IIH) is a condition of significant morbidity and rising prevalence. It typically affects young people living with obesity, mostly women of reproductive age, and can present with headaches, visual abnormalities, tinnitus and cognitive dysfunction. Raised intracranial pressure without a secondary identified cause remains a key diagnostic feature of this condition, however, the underlying pathophysiological mechanisms that drive this increase are poorly understood. Previous theories have focused on cerebrospinal fluid (CSF) hypersecretion or impaired reabsorption, however, the recent characterisation of the glymphatic system in many other neurological conditions necessitates a re-evaluation of these hypotheses. Further, the impact of metabolic dysfunction and hormonal dysregulation in this population group must also be considered. Given the emerging evidence, it is likely that IIH is triggered by the interaction of multiple aetiological factors that ultimately results in the disruption of CSF dynamics. This review aims to provide a comprehensive update on the current theories regarding the pathogenesis of IIH.

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Evolving Evidence in Idiopathic Intracranial Hypertension

Abstract: Idiopathic intracranial hypertension (IIH) is an enigmatic disorder characterized by raised intracranial pressure (ICP) with no known cause and it affects both children and adults [...]

Cited by 3 publications

References 23 publications

Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension

Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension

The expanding spectrum of idiopathic intracranial hypertension

Understanding the pathophysiology of idiopathic intracranial hypertension (IIH): a review of recent developments

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