Evolving changes in Doppler mitral flow velocity pattern in rats with hypertensive hypertrophy

Masuyama, Tohru; Yamamoto, Keiji; Sakata, Yasushi; Doi, Ryohei; Nishikawa, Nagahiro; Kondo, Hiroya; Ono, Keiko; Kuzuya, Tsunehiko; Sugawara, Motoaki; Hori, Masatsugu

doi:10.1016/s0735-1097(00)01000-7

Cited by 83 publications

(57 citation statements)

References 20 publications

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“…However, there was no SHR with an E/A below 1.0, which is frequently seen in patients with hypertension and is a criterion for diastolic dysfunction in humans. The normal value of E/A is almost 2.0 in rats (34) .…”

Section: Discussionmentioning

confidence: 82%

Noninvasive Evaluation of the Time Course of Change in Cardiac Function in Spontaneously Hypertensive Rats by Echocardiography

et al. 2005

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Section: Discussionmentioning

confidence: 82%

Noninvasive Evaluation of the Time Course of Change in Cardiac Function in Spontaneously Hypertensive Rats by Echocardiography

et al. 2005

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“…All subjects in this study had hypertension, and the LV mass index was greater in the DHF patients than in the hypertensive patients without heart failure ( Table 2). Our animal experiments and a recent clinical study have demonstrated that progressive LV hypertrophy is associated with the development of LV fibrosis (27,28), and LV fibrosis plays a crucial role in the enhancement of LV stiffness and the transition from asymptomatic diastolic dysfunction to DHF (27,29,30). LV hypertrophy was not independently associated with the prevalence of DHF (Table 3), and the noninvasive assessment of LV fibrosis is currently difficult.…”

Section: Diastolic Dysfunction and Dhfmentioning

confidence: 74%

Difference of Clinical Characteristics between Hypertensive Patients with and without Diastolic Heart Failure: The Roles of Diastolic Dysfunction and Renal Insufficiency

et al. 2008

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Clinical characteristics were compared between hypertensive patients with and without heart failure in the absence of reduced ejection fraction (EF) to gain insights into the effects of renal insufficiency on the prevalence of diastolic heart failure. Study subjects consisted of 691 hypertensive patients with an EF >40%. Patients with serum creatinine >2.5 mg/dL were excluded from the study. The Framingham heart failure criteria were met by 198 patients, and competing risks of the prevalence of heart failure were analyzed. The multiple logistic regression analysis revealed that obesity, female gender, creatinine clearance (CCr), and a ratio of transmitral E velocity to early diastolic mitral annular velocity (E /E ′) >15 were independently associated with the prevalence of heart failure with preserved EF. Patients with 60≤ CCr <90 mL/min represented higher E /E ′ ratio and lower E ′ velocity than the patients with CCr≥90 mL/min, although there was no difference in the prevalence of heart failure between the two groups. These indices were not different between the patients with 60≤ CCr <90 mL/min and CCr <60 mL/min, although the prevalence of heart failure was higher in the patients with CCr <60 mL/min. The hemoglobin concentration was significantly decreased and the brachial-ankle pulse wave velocity was significantly elevated in patients with CCr <60 mL/min. Thus, progressive left ventricular diastolic dysfunction and renal insufficiency are competing risks of the prevalence of diastolic heart failure in hypertensive patients. Renal insufficiency may exert its effects through the modulation of extracardiac factors such as anemia and arterial stiffening rather than through the promotion of

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“…Peak early diastolic filling velocity (E velocity), peak filling velocity at atrial contraction (A velocity) and their ratio (E/A ratio) were measured for consecutive five cardiac cycles. 22 …”

Section: Animal Preparationmentioning

confidence: 99%

Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin–angiotensin system in hypertensive rats

et al. 2009

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Diabetes mellitus (DM) is a major risk factor for heart failure, independent of coronary artery disease or hypertension (HT). Therefore, our study was designed to examine the mechanisms of DM-induced left ventricular (LV) diastolic dysfunction. In this study, we made five different 10-week treatment groups of Dahl salt-sensitive rats as follows: Control; a low-salt (0.5% NaCl) diet, HT; a high-salt (5% NaCl) diet, DM; a low-salt diet with streptozotocin (STZ) injection (30 mg kg À1 i.p.), HT+DM; a highsalt diet with STZ injection, and the Olmesartan group; a high-salt diet with STZ treated with an angiotensin receptor blocker, olmesartan (1 mg kg À1 day À1 ). Cardiac diastolic dysfunction with a preserved systolic function was noted in the HT group, and was most prominently noted in the HT+DM group, characterized by enhanced cardiac fibrosis, whereas the extent of HT and myocardial hypertrophy was comparable between the two groups. Myocardial expressions of collagen III, transforming growth factor-b2, angiotensin-converting enzyme (ACE), angiotensin II type-1 receptor and myocardial oxidative stress (evaluated by 4-hydroxy-2-nonenal-modified protein) were mostly enhanced in the HT+DM group. Importantly, there was a positive correlation between the extent of diastolic dysfunction and that of myocardial ACE expression. All these cardiac abnormalities induced by DM and HT were ameliorated in the olmesartan group. These results indicate that DM accelerates diastolic dysfunction in hypertensive heart disease through activation of the renin-angiotensin system, with subsequent inflammatory and oxidative stresses and myocardial fibrosis, suggesting that an inhibition of the system is effective for the treatment of diastolic dysfunction in this combined disorder.

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Evolving changes in Doppler mitral flow velocity pattern in rats with hypertensive hypertrophy

Cited by 83 publications

References 20 publications

Noninvasive Evaluation of the Time Course of Change in Cardiac Function in Spontaneously Hypertensive Rats by Echocardiography

Noninvasive Evaluation of the Time Course of Change in Cardiac Function in Spontaneously Hypertensive Rats by Echocardiography

Difference of Clinical Characteristics between Hypertensive Patients with and without Diastolic Heart Failure: The Roles of Diastolic Dysfunction and Renal Insufficiency

Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin–angiotensin system in hypertensive rats

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