Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model
Magdalena Migalska,
Kazimierz Węglarczyk,
Katarzyna Dudek
et al.
Abstract:The immune system is as much shaped by the pressure of pathogens as it is by evolutionary trade-offs that constrain its structure and function. A perfect example comes from the major histocompatibility complex (MHC), molecules that initiate adaptive immune response by presentation of foreign antigens to T cells. The remarkable, population-level polymorphism of MHC genes is assumed to result mainly from a co-evolutionary arms race between hosts and pathogens, while the limited, within-individual number of funct… Show more
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