Evolutionary diversification of type-2 HDAC structure, function and regulation in Nicotiana tabacum

Nicolas-Francès, Valérie; Grandperret, Vincent; Liegard, Benjamin; Jeandroz, Sylvain; Vasselon, Damien; Aimé, Sébastien; Klinguer, Agnès; Lamotte, Olivier; Julio, Emilie; Borne, François Dorlhac de; Wendehenne, David; Bourque, Stéphane

doi:10.1016/j.plantsci.2018.01.007

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…In our current study, SbHDA1, SbHDA3, and SbHDA8 were down-regulated following NaCl treatment and induced by application of ABA, consistent with previous findings. In addition, the NtHD2s helps tobacco to improve the adaptability against salt stress [53]; In rice [32], through yeast two-hybrid screening analysis, it was found that HDA705 can interact with Hsf B1 family protein (RHSF10), and salt responsive WD40 protein (SRWD) to regulate stress response. The above results indicate that sorghum SbHDACs could respond to different abiotic stresses.…”

Section: Discussionmentioning

confidence: 99%

Characterization of histone deacetylases and their roles in response to abiotic and PAMPs stresses in Sorghum bicolor

Fang

Jiang

et al. 2022

BMC Genomics

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Background Histone deacetylases (HDACs) play an important role in the regulation of gene expression, which is indispensable in plant growth, development, and responses to environmental stresses. In Arabidopsis and rice, the molecular functions of HDACs have been well-described. However, systematic analysis of the HDAC gene family and gene expression in response to biotic and abiotic stresses has not been reported for sorghum. Results We conducted a systematic analysis of the sorghum HDAC gene family and identified 19 SbHDACs mainly distributed on eight chromosomes. Phylogenetic tree analysis of SbHDACs showed that the gene family was divided into three subfamilies: RPD3/HDA1, SIR2, and HD2. Tissue-specific expression results showed that SbHDACs displayed different expression patterns in different tissues, indicating that these genes may perform different functions in growth and development. The expression pattern of SbHDACs under different stresses (high and low temperature, drought, osmotic and salt) and pathogen-associated molecular model (PAMPs) elf18, chitin, and flg22) indicated that SbHDAC genes may participate in adversity responses and biological stress defenses. Overexpression of SbHDA1, SbHDA3, SbHDT2 and SbSRT2 in Escherichia coli promoted the growth of recombinant cells under abiotic stress. Interestingly, we also showed that the sorghum acetylation level was enhanced when plants were under cold, heat, drought, osmotic and salt stresses. The findings will help us to understand the HDAC gene family in sorghum, and illuminate the molecular mechanism of the responses to abiotic and biotic stresses. Conclusion We have identified and classified 19 HDAC genes in sorghum. Our data provides insights into the evolution of the HDAC gene family and further support the hypothesis that these genes are important for the plant responses to abiotic and biotic stresses.

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Section: Discussionmentioning

confidence: 99%

Characterization of histone deacetylases and their roles in response to abiotic and PAMPs stresses in Sorghum bicolor

Fang

Jiang

et al. 2022

BMC Genomics

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“…The AtHD2D gene also contributes to plant development and abiotic stress responses ( Han et al., 2016 ). HD2s have been thoroughly studied in dicots as well as in monocots, such as Nicotiana tabacum ( Nicolas-Frances et al., 2018 ), Solanum chacoense ( Demetriou et al., 2009 ), Dimocarpus longan ( Kuang et al., 2012 ; Grandperret et al., 2014 ), Zea mays ( Dangl et al., 2001 ; Pandey et al., 2002 ; Demetriou et al., 2009 ), Oryza sativa ( Fu et al., 2007 ; Ding et al., 2012 ), and Hordeum vulgare ( Demetriou et al., 2009 ; Grandperret et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide identification and expression analysis of the HD2 protein family and its response to drought and salt stress in Gossypium species

Bano

Fakhrah²,

Lone³

et al. 2023

Front. Plant Sci.

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Histone deacetylase 2 (HD2) proteins play an important role in the regulation of gene expression. This helps with the growth and development of plants and also plays a crucial role in responses to biotic and abiotic stress es. HD2s comprise a C2H2-type Zn2+ finger at their C-terminal and an HD2 label, deacetylation and phosphorylation sites, and NLS motifs at their N-terminal. In this study, a total of 27 HD2 members were identified, using Hidden Markov model profiles, in two diploid cotton genomes (Gossypium raimondii and Gossypium arboretum) and two tetraploid cotton genomes (Gossypium hirsutum and Gossypium barbadense). These cotton HD2 members were classified into 10 major phylogenetic groups (I-X), of which group III was found to be the largest with 13 cotton HD2 members. An evolutionary investigation showed that the expansion of HD2 members primarily occurred as a result of segmental duplication in paralogous gene pairs. Further qRT-PCR validation of nine putative genes using RNA-Seq data suggested that GhHDT3D.2 exhibits significantly higher levels of expression at 12h, 24h, 48h, and 72h of exposure to both drought and salt stress conditions compared to a control measure at 0h. Furthermore, gene ontology, pathways, and co-expression network study of GhHDT3D.2 gene affirmed their significance in drought and salt stress responses.

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“…In rice, OsIDS1 physically interacts with the transcriptional corepressors OsTPR1 and OsHDA1 ( Cheng et al, 2018 ). Additionally, another subfamily of HDAC, HD2 (Histone Deacetylase 2), was shown to be plant-specific ( Gu et al, 2011 ; Nicolas-Francès et al, 2018 ). In Poplar lignin, the PtHDT1 mutant of Populus tomentosa , an HD2 subfamily member, has thinner stem nodes, more wood fiber cells, thicker wood fiber cell walls, and higher lignin than the wild type ( Kornet and Scheres, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of the Histone Deacetylases Gene Family in Hemp Reveals Genes Regulating Cannabinoids Synthesis

et al. 2021

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Histone deacetylases (HDACs) play crucial roles nearly in all aspects of plant biology, including stress responses, development and growth, and regulation of secondary metabolite biosynthesis. The molecular functions of HDACs have been explored in depth in Arabidopsis thaliana, while little research has been reported in the medicinal plant Cannabis sativa L. Here, we excavated 14 CsHDAC genes of C. sativa L that were divided into three relatively conserved subfamilies, including RPD3/HDA1 (10 genes), SIR2 (2 genes), and HD2 (2 genes). Genes associated with the biosynthesis of bioactive constituents were identified by combining the distribution of cannabinoids with the expression pattern of HDAC genes in various organs. Using qRT-PCR and transcription group analysis, we verified the expression of candidate genes in different tissues. We found that the histone inhibitor Trichostatin A (TSA) affected the expression of key genes in the cannabinoid metabolism pathway and the accumulation of synthetic precursors, which indirectly indicates that histone inhibitor may regulate the synthesis of active substances in C. sativa L.

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Evolutionary diversification of type-2 HDAC structure, function and regulation in Nicotiana tabacum

Cited by 8 publications

References 40 publications

Characterization of histone deacetylases and their roles in response to abiotic and PAMPs stresses in Sorghum bicolor

Characterization of histone deacetylases and their roles in response to abiotic and PAMPs stresses in Sorghum bicolor

Genome-wide identification and expression analysis of the HD2 protein family and its response to drought and salt stress in Gossypium species

Identification of the Histone Deacetylases Gene Family in Hemp Reveals Genes Regulating Cannabinoids Synthesis

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