Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters
Krishna D. Reddy,
Burha Rasool,
Farideh Badichi Akher
et al.
Abstract:Secondary active membrane transporters use the electrochemical energy of ion gradients to concentrate their substrates. Transporters within the same family often evolve to use different ions, driven by physiological needs or bioavailability. How such functional differences arise despite similar threedimensional protein structures is mostly unknown. We used phylogenetics and ancestral sequence reconstruction on prokaryotic glutamate transporters to recapitulate the evolutionary transition from Na+-coupled (GT-N… Show more
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