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Cited by 5 publications
(3 citation statements)
References 8 publications
(11 reference statements)
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“…It has been used against metastatic BRAF V600E -PTC that is refractory to radioiodine, but response has been variable and relapse is common [6]. Numerous mechanisms can promote resistance through bypass of pharmacologic BRAF V600E inhibition, which enables rebound of ERK1/2 [7, 8]. Another mechanism of resistance involves up-regulation of pro-angiogenic molecules such as the tyrosine kinases (TKs) in the microenvironment [9].…”
Section: Introductionmentioning
confidence: 99%
“…It has been used against metastatic BRAF V600E -PTC that is refractory to radioiodine, but response has been variable and relapse is common [6]. Numerous mechanisms can promote resistance through bypass of pharmacologic BRAF V600E inhibition, which enables rebound of ERK1/2 [7, 8]. Another mechanism of resistance involves up-regulation of pro-angiogenic molecules such as the tyrosine kinases (TKs) in the microenvironment [9].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the prognosis of thyroid cancer, of which the majority are PTC, shows clinical diversity among patients related to age, tumor histology and size, extra‐thyroidal extension, metastasis, and thyroid follicular cell avidity for iodide. Many patients develop resistance within ∼12 months of initiation of therapy . It has become more urgent to discover the underlying mechanisms and develop new therapeutic strategies for thyroid cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Many patients develop resistance within ∼12 months of initiation of therapy. 21 It has become more urgent to discover the underlying mechanisms and develop new therapeutic strategies for thyroid cancer.…”
Section: Discussionmentioning
confidence: 99%
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