Evolution and Clinical Trend of SARS-CoV-2 Variants

Lorente-González, Miguel; Suarez-Ortiz, Miguel; Landete, Pedro

doi:10.1016/j.opresp.2022.100169

Cited by 19 publications

(22 citation statements)

References 8 publications

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“…This could be due to the fact that Delta variant is more efficient at evading immune responses than previous strains. 275,276 Omicron variant may cause a less severe cytokine response, but it is important to note that CS can still occur in some individuals infected with this variant. 277 The chemokines recruit more inflammatory cells to the inflamed region, including monocytes and phagocytes.…”

Section: Cytokine Storm Syndrome In Covid-19mentioning

confidence: 99%

“…Although the Delta variant has been found to have higher morbidity and mortality rates, it produces lower cytokine levels than other variants. This could be due to the fact that Delta variant is more efficient at evading immune responses than previous strains 275,276 . Omicron variant may cause a less severe cytokine response, but it is important to note that CS can still occur in some individuals infected with this variant 277 .…”

Section: Csmentioning

confidence: 99%

“…The original Alpha strain had a greater tendency to affect the lower respiratory tract and lung tissue, while Delta and Omicron variants tend to case symptoms like runny nose and sneezing more frequently 274 . Despite the fact that the Delta variation is considered to be the one associated with increased morbidity and death 275 . Although the Delta variant has been found to have higher morbidity and mortality rates, it produces lower cytokine levels than other variants.…”

Section: Csmentioning

confidence: 99%

“…274 Despite the fact that the Delta variation is considered to be the one associated with increased morbidity and death. 275 Although the Delta variant has been found to have higher morbidity and mortality rates, it produces lower cytokine levels than other variants. This could be due to the fact that Delta variant is more efficient at evading immune responses than previous strains.…”

Section: Cytokine Storm Syndrome In Covid-19mentioning

confidence: 99%

See 3 more Smart Citations

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

Qudus

Tian

Sirajuddin

et al. 2023

Journal of Medical Virology

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In patients with severe COVID-19, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm, which is a hyperinflammatory medical condition caused by the excessive and uncontrolled release of pro-inflammatory cytokines. High levels of numerous crucial pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-2, IL-6, tumor necrosis factor-α, interferon (IFN)-γ, IFN-induced protein 10 kDa, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1, and IL-10 and so on, have been found in severe COVID-19. They participate in cascade amplification pathways of pro-inflammatory responses through complex inflammatory networks. Here, we review the involvements of these critical inflammatory cytokines in SARS-CoV-2 infection and discuss their potential roles in triggering or regulating cytokine storm, which can help to understand the pathogenesis of severe COVID-19. So far, there is rarely effective therapeutic strategy for patients with cytokine storm besides using glucocorticoids, which is proved to result in fatal side effects. Clarifying the roles of key involved cytokines in the complex inflammatory network of cytokine storm will help to develop an ideal therapeutic intervention, such as neutralizing antibody of certain cytokine or inhibitor of some inflammatory signal pathways.

show abstract

Section: Cytokine Storm Syndrome In Covid-19mentioning

confidence: 99%

Section: Csmentioning

confidence: 99%

Section: Csmentioning

confidence: 99%

Section: Cytokine Storm Syndrome In Covid-19mentioning

confidence: 99%

See 2 more Smart Citations

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

Qudus

Tian

Sirajuddin

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Although the inhibitors of SARS-CoV-2 entry as well as different vaccines have been developed to prevent the SARS-CoV-2 infection and eradicate the COVID-19 pandemic. However, several mutations in the genome of SARS‐CoV‐2 lead to new variants of viruses such as the Alpha, Delta, and Omicron variants which are linked to the altered transmissibility and pathogenicity [10] , [11] . For instance, the mutated protein in the Omicron variant results in the enhanced affinity to ACE2 associated with accelerated internalization and fusion process [12] .…”

Section: Introductionmentioning

confidence: 99%