Evidence that angiotensin-(1–7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors

Fontes, Marco Antônio Peliky; Silva, L.C.S.; Campagnole‐Santos, Maria José; Khosla, M. C.; Guertzenstein, P.G.; Santos, Robson Augusto Souza

doi:10.1016/0006-8993(94)91171-1

Cited by 141 publications

(145 citation statements)

References 18 publications

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“…A natriuretic effect of Ang-(1-7) in isolated rat kidneys (16) or in denervated rat kidneys in vivo (17) has also been described. Ongoing studies strongly suggest that these biological effects are mediated by specific receptors (10,11). These data indicate that Ang-(1-7) could be involved in the mediation of important central and peripheral actions of the RAS.…”

Section: Introductionmentioning

confidence: 90%

“…There is growing evidence that the actions of Ang-(1-7) in the kidney or other sites are mediated by specific receptors (3,10,11,17,22,45,52,53). In the kidney the antidiuretic action of Ang-(1-7) in water-loaded rats is blocked by the selective Ang- (1-7) antagonist A-779 which shows very low affinity for classical angiotensin II receptors (AT 1 and AT 2 subtypes) (22).…”

Section: Angiotensin-(1-7) and Angiotensin Receptorsmentioning

confidence: 99%

“…Although further studies are obviously needed to demonstrate the existence of specific Ang-(1-7) receptors, the observations made with the Ang-(1-7) analogue D-Ala 7 -Ang-(1-7) (A-779) in the brain (10,11,45,55) and in the periphery (22) strongly suggest that a non-AT 1 , non-AT 2 receptor mediates the biological actions of Ang-(1-7).…”

Section: Angiotensin-(1-7) and Angiotensin Receptorsmentioning

confidence: 99%

“…In vitro this peptide is a potent vasopressin secretagogue (5) and possesses a potent prostaglandin-releasing activity in several cell lines (6,7). Microinjection of this angiotensin into the dorsomedial or ventrolateral medulla produces significant changes in mean arterial pressure and heart rate, comparable to those produced by Ang II (8)(9)(10)(11). Furthermore, intracerebroventricular infusion of Ang-(1-7) in rats increased baroreceptor reflex sensitivity, an effect that was opposite to that observed with Ang II infusion (12).…”

Section: Introductionmentioning

confidence: 95%

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Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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Section: Introductionmentioning

confidence: 90%

Section: Angiotensin-(1-7) and Angiotensin Receptorsmentioning

confidence: 99%

Section: Angiotensin-(1-7) and Angiotensin Receptorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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“…During the last decade, studies using the selective angiotensin-(1-7) (Ang-(1-7)) antagonist D-Ala 7 -Ang-(1-7) (A-779) (Santos et al, 1994) provided pharmacological evidence for an Ang-(1-7) receptor distinct from the classical Ang II receptors AT 1 and AT 2 (Fontes et al, 1994;Ferrario et al, 1998;Santos et al, 2000;Heringer-Walther et al, 2001). These findings were recently corroborated by the identification of an Ang-(1-7) receptor, the G protein-coupled receptor Mas .…”

Section: Introductionmentioning

confidence: 99%

Evidence for a functional cardiac interaction between losartan and angiotensin‐(1–7) receptors revealed by orthostatic tilting test in rats

Moura¹,

Santos²,

Fontes³

2005

British J Pharmacology

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1 Studies have shown that the angiotensin II (Ang II) AT 1 receptor antagonist, losartan, accentuates the orthostatic hypotensive response in anesthetized rats, and there is evidence indicating that this effect is not exclusively mediated by AT 1 receptors. 2 We investigated whether the pronounced orthostatic cardiovascular response observed in losartantreated rats involves an interference with angiotensin-(1-7) (Ang-(1-7)) receptors. 3 Urethane-anesthetized rats were submitted to orthostatic stress (901 head-up tilt for 2 min). Intravenous injection of losartan (1 mg kg À1 , n ¼ 9) significantly accentuated the decrease in mean arterial pressure (MAP) induced by head-up tilt (À3376% after losartan vs À1578% control tilt). This effect was accompanied by a significant bradycardia (À873% after losartan vs À373% control tilt). Another AT 1 antagonist, candesartan, did not potentiate the decrease of MAP and did not change the cardiac response induced by head-up tilt. Strikingly, administration of the Ang-(1-7) antagonist, A-779 (10 nmol kg À1 , n ¼ 5), totally reversed the bradicardiac effect caused by losartan and this effect was accompanied by a tendency towards attenuation of the hypotensive response caused by losartan. 4 These findings indicate that the marked orthostatic cardiovascular response is specific for losartan, and that it may be due, in part, to an interaction of this antagonist with Ang-(1-7) receptors, probably at the cardiac level.

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Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT2 subtype receptors at nucleus reticularis ventrolateralis in the rat

Lin¹,

Chan

2001

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Evidence that angiotensin-(1–7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors

Cited by 141 publications

References 18 publications

Renal actions of angiotensin-(1-7)

Renal actions of angiotensin-(1-7)

Evidence for a functional cardiac interaction between losartan and angiotensin‐(1–7) receptors revealed by orthostatic tilting test in rats

Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT2 subtype receptors at nucleus reticularis ventrolateralis in the rat

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