2010
DOI: 10.1038/nature08956
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients.1,2 Fire et al. first demonstrated that long, double stranded RNAs mediate RNAi in Caenorhabditis elegans,3 and Elbashir et al. opened the pathway to the use of RNAi for human therapy by showing that small interfering RNAs (siRNAs: ca. 21 base pair double stranded RNA) can elicit RNAi in mammalian cells without producing an interferon response.4 We are current… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

9
1,676
1
15

Year Published

2011
2011
2019
2019

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 2,244 publications
(1,701 citation statements)
references
References 25 publications
9
1,676
1
15
Order By: Relevance
“…58 In a few patients, gene knockdown and siRNA delivery to biopsied melanoma tumors was demonstrated, but no clinical effects have yet been reported. 59 Targeted liposomes. Integrin antibodies have also been used to construct liposomes that efficiently knock down gene expression in specific subsets of immune cells in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…58 In a few patients, gene knockdown and siRNA delivery to biopsied melanoma tumors was demonstrated, but no clinical effects have yet been reported. 59 Targeted liposomes. Integrin antibodies have also been used to construct liposomes that efficiently knock down gene expression in specific subsets of immune cells in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…Nanoparticles have been proposed as carriers for drugs, genes and therapies to treat various diseases 1 The potential of targeting nanomedicines has already been illustrated in practice [5][6][7] . Among these general approaches, the role of nanomedicines exploiting active targeting via specific ligands is increasing in prominence [8][9][10] .…”
mentioning
confidence: 99%
“…2 RNAi is a naturally occurring biological process which results in specific silencing of a target gene by short sequences of RNA known as small interfering RNAs (siRNAs), 3 with a subsequent reduction in the expression of the corresponding protein. Introduction of chemically synthesized siRNA into cells to reduce expression of a specific gene can be used to determine gene function or for therapeutic purposes.…”
mentioning
confidence: 99%