Evidence of oxidative damage and reproductive dysfunction accompanying 4-vinylcyclohexene diepoxide exposure in female Wistar rats

Abolaji, Amos O.; Adedara, Isaac A.; Abajingin, Ayodeji O.; Fatunmibi, Ore J.; Ladipo, Emmanuel O.; Farombi, Ebenezer O.

doi:10.1016/j.reprotox.2016.09.009

Cited by 15 publications

(10 citation statements)

References 53 publications

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“…In the present study, iNOS expression levels were increased in the ovaries of the EMF-exposed group. Increased iNOS expression in the ovary was detected in earlier studies about ovarian ischemia or toxicity (Abolaji et al, 2016;Refaie and El-Hussieny, 2018). In male mice, exposure to 50-Hz EMF for 4 h/day has been shown to cause increased NOS levels in brain tissue (Duan et al, 2013).…”

Section: Discussionmentioning

confidence: 80%

The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue

et al. 2020

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Exposure to an electromagnetic field (EMF) can have adverse effects on many organs and tissues, including the reproductive system. This study aimed to investigate the effects of EMF exposure during prenatal and postnatal periods on ovarian development in rat offspring. In this study, rat pups born from eight pregnant rats were used. EMF exposure was initiated on the first day of pregnancy and continued until the 42nd postnatal day. The blood and ovarian tissue samples of female offspring in sham and EMF groups were collected when they reached the age of 42 days. Follicle-stimulating hormone levels were significantly higher in the EMF group than in the sham group. Estradiol levels were significantly lower in the EMF group than in the sham group. Tissue-inducible nitric oxide synthase (iNOS) levels and expression were significantly greater in the EMF group than in the sham group. In the EMF group, congestion, bleeding areas, and degeneration of follicle structures were observed in ovarian tissue. The findings suggest that exposure to 50-Hz, 3-mT EMF used in this study during prenatal and postnatal periods may lead to impaired ovarian structure and function in female offspring. EMF may affect ovarian physiology by increasing iNOS levels and may lead to fertility disorders.

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Section: Discussionmentioning

confidence: 80%

The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue

et al. 2020

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“…These experimental results are consistent with the following literature data. Previous studies have shown that psychological disorders, oxidative stress and inflammation are associated with infertility [1,5,6,14]. Aksoy et al have showed that oxidative stress is one of the main causes of infertility due to ovarian I/R injury [41].…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies have also shown that proinflammatory cytokines increase in anxiety disorders [13]. Therefore, oxidative stress and inflammation have been recognized among the basic reasons of reproductive dysfunction in many studies [14]. The act of oxidative stress and inflammation in pathologies like spontaneous abortions, embryopathies, preeclampsia, fetal growth restriction, preterm, and miscarriage affecting female reproductive processes is well known [15,16].…”

Section: Introductionmentioning

confidence: 99%

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Kadıoğlu¹,

Gündoğdu²,

Kurt³

et al. 2020

Clinical and Experimental Obstetrics & Gynecology

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The aim of the study was to examine the possible effect of Rhodiola rosea root extract (RRE) on ovarian damage, infertility (IF), delay in conception (DC), decrease in the number of offspring (NO) in female rats that have been stressed with compulsory immobilization method (CIM) and on retardation of intrauterine physical development (IPD) in offspring. Materials and methods: Female Albino Wistar rats were divided like: healthy (HG), stress-induced control (SC), and stress + 50 mg/kg RRE (S + REG) groups including sixteen rats in each group. Six rats from each group were killed for conducting biochemical and histopathological examinations in ovarian tissues and others were observed for IF, DC, NO, and IPD. Results: It was found that RRE significantly prevented the increase in oxidative parameters and proinflammatory cytokine levels in ovarian tissue of animals stressed with CIM. RRE suppressed the increase in IF rate and DC whereas caused a decrease in NO and in IPD retardation. Conclusion: These results suggested RRE may have beneficial effects in the treatment of stress induced reproductive dysfunction. Content: The effect of RRE on oxidative and inflammatory changes in ovarian tissue and reproductive changes of animals exposed to stress with compulsory immobilization method.

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“…Therefore, thiol-containing proteins can be targeted by epoxides in cells representing one of the mechanisms of VCH metabolites toxicity. In rodents, VCH and its metabolites have been associated mainly with ovarian damage characterized by the death of primary and primordial follicles [13–15]. Besides, exposure to VCH or its epoxides has been shown to cause toxic effects in various organs in rodents [15–19].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous exposure to vinylcyclohexene and methylmercury in Drosophila melanogaster: biochemical and molecular analyses

Piccoli

Segatto

Oliveira

et al. 2019

BMC Pharmacol Toxicol

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BackgroundExposure to vinylcyclohexene (VCH) and methylmercury (MeHg+) can induce oxidative stress and gene modulation. Several studies have been evaluating the effects of VCH and MeHg+, but little is known about interactive effects between them. This work aimed to assess the exposure and co-exposure effects of MeHg+ and VCH on oxidative stress and gene modulation in Drosophila melanogaster.MethodsReactive species production, glutathione S-transferase (GST) and acetylcholinesterase (AChE) activities were evaluated after exposure and co-exposure to VCH (1 mM) and MeHg+ (0.2 mM) for one or three days in the head and body (thorax and abdomen) of flies. The expression of genes related to redox state and inflammatory response was evaluated after exposure and co-exposure to VCH and MeHg+ for three days.ResultsSurvival decreased only in flies co-exposed to VCH and MeHg+ for three days. All treatments increased total reactive species production after one day of exposure. However, no significant changes were observed in the head after three days of exposure. One day of exposure to VCH caused an increase in the head GST activity, whereas MeHg+ induced an increase after three days of exposure. Regarding the body, all treatments increased GST activity after one day of exposure, but only the flies exposed to MeHg+ presented an increase in GST activity after three days of exposure. Treatments did not alter AChE activity in the head. As for gene expression, there was a significant increase in the Relish transcription factor gene in the flies’ body, but Nrf2, Keap1, Jafrac1, TrxR1, and NF-κβ were not altered.ConclusionThe results suggest that exposure to VCH and MeHg+ induce oxidative stress and activation of an inflammatory response in fruit flies.

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Evidence of oxidative damage and reproductive dysfunction accompanying 4-vinylcyclohexene diepoxide exposure in female Wistar rats

Cited by 15 publications

References 53 publications

The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue

The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Simultaneous exposure to vinylcyclohexene and methylmercury in Drosophila melanogaster: biochemical and molecular analyses

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