Evidence of myocardial hibernation in the septic heart*

Levy, Richard J.; Piel, David; Acton, Paul D.; Zhou, Rong; Ferrari, Victor A.; Karp, Joel S.; Deutschman, Clifford S.

doi:10.1097/01.ccm.0000189943.60945.77

Cited by 171 publications

(93 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with other studies documenting myocardial depression in sepsis in both animal models [23] and humans [24,25]. By 24 h, when sepsis had become established, haemodynamic function had improved, despite persisting hyperlactataemia and a marked increase in clinical severity.…”

Section: Discussionsupporting

confidence: 80%

Temporal changes in tissue cardiorespiratory function during faecal peritonitis

2011

View full text Add to dashboard Cite

This long-term septic model exhibited an early decline in tissue oxygenation, the degree of which related to predicted mortality. Clinical and biochemical deterioration, however, progressed despite cardiovascular recovery. Early circulatory dysfunction may thus be an important trigger for downstream processes that result in multi-organ failure. Furthermore, the utility of tissue PO2 monitoring to highlight the local oxygen supply-demand balance, and dynamic O2 challenge testing to assess microcirculatory function merit further investigation.

show abstract

Section: Discussionsupporting

confidence: 80%

Temporal changes in tissue cardiorespiratory function during faecal peritonitis

2011

View full text Add to dashboard Cite

show abstract

“…Hypothermia and reduced metabolism, the hallmarks of hibernation, are frequently seen in experimental sepsis and in septic neonates (50,51,52). Furthermore, evidence of myocardial hibernation has recently been demonstrated in the septic heart in the absence of ischemia or hypoxia (38).…”

Section: Metabolic Down-regulation and Hibernationmentioning

confidence: 99%

“…Sepsis is one disease process in which cellular hibernation has been proposed to underlie organ failure (2,38,49). During sepsis, there is often profound organ dysfunction with histologic absence of injury and minimal cell death (49).…”

Section: Metabolic Down-regulation and Hibernationmentioning

confidence: 99%

Mitochondrial Dysfunction, Bioenergetic Impairment, and Metabolic Down-Regulation in Sepsis

Levy

2007

Shock

Self Cite

135

View full text Add to dashboard Cite

Mitochondrial dysfunction is thought to play an important role in the pathogenesis of many different disease states. It has been proposed that an acquired defect in oxidative phosphorylation prevents cells from using molecular oxygen for adenosine triphosphate production and potentially causes sepsis-induced organ dysfunction. This concept, termed cytopathic hypoxia, however, has been difficult to prove because impaired oxidative phosphorylation has never been shown to cause sepsis-induced organ failure or to be a reversible phenomenon. Presented here is are view of oxidative phosphorylation, evidence of defective electron-transport-chain function in the heart and other organ systems during sepsis, and support for a link between mitochondrial dysfunction and pathologic metabolic down-regulation.

show abstract

“…In a previous study, we have demonstrated that sepsis also causes diastolic dysfunction associated with an, increase in both the left ventricular filling pressure (LVEDP) and the rate constant (tau) for left ventricular relaxation time during hyperdynamic state of sepsis (1-day post-sepsis) (Chopra and Sharma, 2007). Other investigators have also provided evidence for altered cardiodynamic responses in both animal and clinical models of sepsis (Brahmbhatt et al, 2005;Levy et al, 2005;Meldrum et al, 2005;Sharma, 2007).…”

Section: Introductionmentioning

confidence: 92%