Evidence of immunosuppression by Demodex canis

Barriga, Omar O.; Al-Khalidi, Nahad W.; Martin, S. L.; Wyman, Milton

doi:10.1016/0165-2427(92)90067-z

Cited by 41 publications

(36 citation statements)

References 10 publications

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“…The role of increased TGF-β mRNA expression in PBMC from dogs with GD remains to be further characterized and might be complex. However, increased TGF-β mRNA expression may be associated with the immunosuppression seen in dogs with GD [3,20,28]. It is also possible that TGF-β might be secreted to protect cytotoxic immunity, such as that of CD8 + T cells [5].…”

Section: Discussionmentioning

confidence: 98%

“…Canine demodicosis is classified as either localized (LD) or generalized (GD) depending on the extent of the skin lesions, and their immunological responses differ [3,28]. The decrease in the mitogen-stimulated response of peripheral blood mononuclear cells (PBMC) is more severe in GD than in LD [3,25]. Caswell et al [5] reported that the cell-mediated immune response may suppress the development of GD.…”

mentioning

confidence: 99%

“…on the skin surface [8]. It has been thought that immunodeficiency may contribute to the development of demodicosis [3,20,28]. Canine demodicosis is classified as either localized (LD) or generalized (GD) depending on the extent of the skin lesions, and their immunological responses differ [3,28].…”

mentioning

confidence: 99%

“…It has been thought that immunodeficiency may contribute to the development of demodicosis [3,20,28]. Canine demodicosis is classified as either localized (LD) or generalized (GD) depending on the extent of the skin lesions, and their immunological responses differ [3,28]. The decrease in the mitogen-stimulated response of peripheral blood mononuclear cells (PBMC) is more severe in GD than in LD [3,25].…”

mentioning

confidence: 99%

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Evaluation of Cytokine Messenger RNA Expression in Peripheral Blood Mononuclear Cells from Dogs with Canine Demodicosis.

Tani

Morimoto

Hayashi

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. Using RT-PCR and semi-quantitative PCR, mRNA expression for canine interferon (IFN)-γ, interleukin (IL)-2, IL-4, IL-5, IL-10, tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β in peripheral blood mononuclear cells (PBMCs) was examined in dogs with or without demodicosis. mRNA expression for IFN-γ as well as TNF-α in dogs with demodicosis (localized (LD) and generalized (GD)) was slightly lower than those in dogs without demodicosis (healthy controls). Expression of IL-5 mRNA in dogs with demodicosis was higher than that in control dogs, but there were no significant differences in IL-4 and IL-10 mRNA expression levels among the three groups. On the other hand, expression levels of TGF-β mRNA in dogs with GD were higher than those in control dogs and dogs with LD. The expression levels of IL-5 and TGF-β mRNA decreased in all three dogs with GD which showed resolution of the clinical signs. Taken together, these results suggest that the Th2-like response in PBMCs from dogs with demodicosis is up-regulated, and that subsequent increased expression of IL-5 and TGF-β mRNA in dogs with GD is reversible after treatment. Therefore, these cytokines, particularly IL-5, might be a useful clinical index of the clinical course in demodicosis. Also, increased TGF-β mRNA expression might be a key factor for revealing the difference in the mechanism of onset between LD and GD.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Cytokine Messenger RNA Expression in Peripheral Blood Mononuclear Cells from Dogs with Canine Demodicosis.

Tani

Morimoto

Hayashi

et al. 2002

The Journal of Veterinary Medical Science

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“…[202223] The fact that people and animals with immunodeficiency are prone to infestation with Demodex mites has been shown repeatedly. [2425]…”

Section: Introductionmentioning

confidence: 99%

Human Demodex Mite: The Versatile Mite of Dermatological Importance

2014

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Demodex mite is an obligate human ecto-parasite found in or near the pilo-sebaceous units. Demodex folliculorum and Demodex brevis are two species typically found on humans. Demodex infestation usually remains asymptomatic and may have a pathogenic role only when present in high densities and also because of immune imbalance. All cutaneous diseases caused by Demodex mites are clubbed under the term demodicosis or demodicidosis, which can be an etiological factor of or resemble a variety of dermatoses. Therefore, a high index of clinical suspicion about the etiological role of Demodex in various dermatoses can help in early diagnosis and appropriate, timely, and cost effective management.

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2012

Parasitology

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Evidence of immunosuppression by Demodex canis

Cited by 41 publications

References 10 publications

Evaluation of Cytokine Messenger RNA Expression in Peripheral Blood Mononuclear Cells from Dogs with Canine Demodicosis.

Evaluation of Cytokine Messenger RNA Expression in Peripheral Blood Mononuclear Cells from Dogs with Canine Demodicosis.

Human Demodex Mite: The Versatile Mite of Dermatological Importance

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