Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Blasdell, Kim R.; Duong, Veasna; Éloit, Marc; Chrétien, Fabrice; Ly, Sowath; Hul, Vibol; Denis, Vincent; Morand, Sergé; Buchy, Philippe

doi:10.7554/elife.13135

Cited by 55 publications

(66 citation statements)

References 47 publications

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“…Blasdell et al . (,b) identified a variant of Wenzhou virus (Cardamones virus) and a related virus named Loei River virus, in two of the localities analysed in the present study. Loei River virus was found associated with B. indica, B. savilei , and N. fulvescens , and Cardamones virus with R. norvegicu s and R. exulans (Table ).…”

Section: Resultsmentioning

confidence: 60%

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Forecasting potential emergence of zoonotic diseases in South‐East Asia: network analysis identifies key rodent hosts

Bordes

Caron

Blasdell

et al. 2016

Journal of Applied Ecology

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Summary Within complex ecological systems, identifying animal species likely to play a key role in the emergence of infectious zoonotic diseases remains a major challenge. One approach consists of using information on current ecological and parasitological similarities among host species in order to predict the most likely pathways for future pathogen spillover. Using field data acquired from 15 sympatric rodent species in various habitats in Thailand, Cambodia and Laos, we built networks based on shared parasites (17 helminth and 15 microparasite species) and shared habitats among rodent species and humans. We investigated the architectures of bipartite and unipartite networks using modularity, subgroups partitioning or node centrality, to assess the relative epidemiological importance of particular rodent species. Our results showed that Rattus tanezumi, Bandicota savilei and R. exulans were consistently found to be members of subgroups that included humans in unipartite and bipartite networks on zoonotic agents and shared habitats. High values of centrality in shared zoonotic agents were found for the same three rodent species, whereas high values of shared habitats were observed for two of them. Although phylogenetically related rodent species likely shared both habitats and parasites, a lack of habitat specialization was associated with increased zoonotic parasite sharing. Our results emphasize the disproportionate importance of these three rodent species, through their high degree of connectivity with humans, which may represent a high risk for direct zoonotic spillover. Moreover, due to its high centrality in habitats, R. tanezumi may also play a key role as a bridge host. The recent discovery of new arenaviruses in rodents in South‐East Asia, with associated disease in humans in Cambodia, provides an opportunity to test this empirically. The three rodent species identified using our network approach are some of the potential maintenance hosts for these new emerging arenaviruses. Synthesis and applications. Our results on rodents and their pathogens in South‐East Asia show that network analysis has a high potential to improve the surveillance of emerging zoonotic pathogens by targeting key host species and potential ‘emerging’ pathogen–rodent interactions in complex and heterogeneous landscapes.

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Section: Resultsmentioning

confidence: 60%

“…In addition to identifying these arenaviruses in SEA, Blasdell et al . (,b) also provided evidence of arenavirus‐associated human infection in Asia.…”

Section: Resultsmentioning

confidence: 94%

Forecasting potential emergence of zoonotic diseases in South‐East Asia: network analysis identifies key rodent hosts

Bordes

Caron

Blasdell

et al. 2016

Journal of Applied Ecology

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“…, Blasdell et al. , ). Globally, China reports the highest number of human hantavirus cases annually, but only isolated cases have so far been reported from other Southeast Asian countries.…”

Section: Discussionmentioning

confidence: 98%

Changing landscapes of Southeast Asia and rodent‐borne diseases: decreased diversity but increased transmission risks

Morand

Blasdell

Bordes

et al. 2019

Ecological Applications

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The reduction in biodiversity from land use change due to urbanization and agricultural intensification appears to be linked to major epidemiological changes in many human diseases. Increasing disease risks and the emergence of novel pathogens result from increased contact among wildlife, domesticated animals, and humans. We investigated the relationship between human alteration of the environment and the occurrence of generalist and synanthropic rodent species in relation to the diversity and prevalence of rodent‐borne pathogens in Southeast Asia, a hotspot of threatened and endangered species, and a foci of emerging infectious diseases. We used data from an extensive pathogen survey of rodents from seven sites in mainland Southeast Asia in conjunction with past and present land cover analyses. At low spatial resolutions, we found that rodent‐borne pathogen richness is negatively associated with increasing urbanization, characterized by increased habitat fragmentation, agriculture cover and deforestation. However, at a finer spatial resolution, we found that some major pathogens are favored by environmental characteristics associated with human alteration including irrigation, habitat fragmentation, and increased agricultural land cover. In addition, synanthropic rodents, many of which are important pathogen reservoirs, were associated with fragmented and human‐dominated landscapes, which may ultimately enhance the opportunities for zoonotic transmission and human infection by some pathogens.

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“…The virus was hypothesized to be spreading more widely among humans in Asia. 13 The microorganism Anaplasma capra was first isolated from goats in China. The corresponding human infections were then identified in northern China, where the risk of exposure to novel tick-borne pathogens is higher.…”

Section: Discovery Of New Potentially Pathogenic Microorganisms In Anmentioning

confidence: 99%

Reverse microbial etiology: A research field for predicting and preventing emerging infectious diseases caused by an unknown microorganism

2019

Journal of Biosafety and Biosecurity

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a b s t r a c tTo predict, detect, prepare for, and prevent potential emerging infectious diseases caused by unknown microorganisms in the future, we have proposed the research field of reverse microbial etiology. We isolate and classify unknown microorganisms and assesse their ability to cause infection, an outbreak, or epidemic. We suggest a list of potential pathogens and propose a preparation, prevention, and control strategy to protect global health and global economy and to ensure global security.

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Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Cited by 55 publications

References 47 publications

Forecasting potential emergence of zoonotic diseases in South‐East Asia: network analysis identifies key rodent hosts

Forecasting potential emergence of zoonotic diseases in South‐East Asia: network analysis identifies key rodent hosts

Changing landscapes of Southeast Asia and rodent‐borne diseases: decreased diversity but increased transmission risks

Reverse microbial etiology: A research field for predicting and preventing emerging infectious diseases caused by an unknown microorganism

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