Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

Patterson, Edward I; Elia, Gabriella; Grassi, Andrea; Giordano, Alessia; Desario, Costantina; Medardo, M.; Smith, Stephen; Anderson, Enyia R; Prince, Tessa; Patterson, Glenn; Lorusso, Eleonora; Lucente, Maria Stella; Lanave, Gianvito; Lauzi, Stefania; Bonfanti, Ugo; Stranieri, Angelica; Martella, Vito; Basano, Fabrizio Solari; Barrs, Vanessa R.; Radford, Alan; Agrimi, Umberto; Hughes, Grant L; Paltrinieri, Saverio; Decaro, Nicola

doi:10.1038/s41467-020-20097-0

Cited by 342 publications

(509 citation statements)

References 22 publications

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“…Other epidemiological studies have been conducted that included samples collected from animals presenting for routine veterinary visits, where there was no known exposure to people infected with SARS-CoV-2. A study of 919 companion animals in Northern Italy that were sampled at a time of frequent human infection reported that 3.3% of dogs and 5.8% of cats displayed titres of neutralising antibodies [70]. In this study, 69 samples for serology originated from dogs (47) and cats (22) from a known COVID-19 affected household and 12.8% (6/47) of these dogs and 4.5% (1/22) of these cats tested positive for SARS-CoV-2-neutralizing antibodies; in addition, the seroprevalence found in dogs from a known COVID-19 positive household was significantly higher than dogs from COVID-19 negative households (1.5%; 2/133) [70].…”

Section: Prevalence Of Sars-cov-2 Infection In Domestic Animalsmentioning

confidence: 99%

Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic

Hosie

Hofmann‐Lehmann

Hartmann³

et al. 2021

Viruses

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COVID-19 is a severe acute respiratory syndrome (SARS) caused by a new coronavirus (CoV), SARS-CoV-2, which is closely related to SARS-CoV that jumped the animal–human species barrier and caused a disease outbreak in 2003. SARS-CoV-2 is a betacoronavirus that was first described in 2019, unrelated to the commonly occurring feline coronavirus (FCoV) that is an alphacoronavirus associated with feline infectious peritonitis (FIP). SARS-CoV-2 is highly contagious and has spread globally within a few months, resulting in the current pandemic. Felids have been shown to be susceptible to SARS-CoV-2 infection. Particularly in the Western world, many people live in very close contact with their pet cats, and natural infections of cats in COVID-19-positive households have been described in several countries. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European Countries, discusses the current status of SARS-CoV infections in cats. The review examines the host range of SARS-CoV-2 and human-to-animal transmissions, including infections in domestic and non-domestic felids, as well as mink-to-human/-cat transmission. It summarises current data on SARS-CoV-2 prevalence in domestic cats and the results of experimental infections of cats and provides expert opinions on the clinical relevance and prevention of SARS-CoV-2 infection in cats.

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Section: Prevalence Of Sars-cov-2 Infection In Domestic Animalsmentioning

confidence: 99%

Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic

Hosie

Hofmann‐Lehmann

Hartmann³

et al. 2021

Viruses

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“…In a large-scale study assessing SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection, none of these pets tested PCR positive. However, 3.3% of dogs and 5.8% of cats had measurable SARS-CoV-2 neutralizing antibody titres; dogs from COVID-19 positive households were significantly more likely to test positive than those from COVID-19 negative households ( 13 ). Higher seroprevalence rates for SARS-CoV-2, ranging from 21 to 53% depending of the test used, were observed in domestic carnivores from COVID-19 positive household in two French regions ( 14 ).…”

Section: Can Dogs and Cats Be Infected By Sars-cov-2?mentioning

confidence: 99%

SARS-CoV-2 Infection in Dogs and Cats: Facts and Speculations

et al. 2021

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“…Despite increased understanding from experimental research on felids, cats are not standard experimental animals and are difficult to handle in biosafety 3 settings [174]. Additional field investigations could circumvent these logistical challenges by monitoring environmental contamination (e.g., litter box, food, water bowls) or transmission efficiency between owners and domestic cats [174,175].…”

Section: Felidsmentioning

confidence: 99%

“…On 28 February 2020, in Hong Kong, the first domestic dog that tested positive for SARS-CoV-2 was reported in a Pomeranian dog belonging to an owner that was previously tested positive for SARS-CoV-2 [235]. Subsequent asymptomatic dog infections in Hong Kong were reported; all sharing living environment with at least one SARS-CoV-2-positive owner [175,236,237]. During the same period, in the Netherlands, one pet dog was reported positive for SARS-CoV-2 and its owner had previously been hospitalized for SARS-CoV-2 [238].…”

Section: Canidsmentioning

confidence: 99%

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

Hedman¹,

Krawczyk

Helmy

et al. 2021

Pathogens

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Emerging infectious diseases present great risks to public health. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become an urgent public health issue of global concern. It is speculated that the virus first emerged through a zoonotic spillover. Basic research studies have suggested that bats are likely the ancestral reservoir host. Nonetheless, the evolutionary history and host susceptibility of SARS-CoV-2 remains unclear as a multitude of animals has been proposed as potential intermediate or dead-end hosts. SARS-CoV-2 has been isolated from domestic animals, both companion and livestock, as well as in captive wildlife that were in close contact with human COVID-19 cases. Currently, domestic mink is the only known animal that is susceptible to a natural infection, develop severe illness, and can also transmit SARS-CoV-2 to other minks and humans. To improve foundational knowledge of SARS-CoV-2, we are conducting a synthesis review of its host diversity and transmission pathways. To mitigate this COVID-19 pandemic, we strongly advocate for a systems-oriented scientific approach that comprehensively evaluates the transmission of SARS-CoV-2 at the human and animal interface.

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Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

Cited by 342 publications

References 22 publications

Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic

Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic

SARS-CoV-2 Infection in Dogs and Cats: Facts and Speculations

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

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