volume 9, issue 1, P52-67 2016
DOI: 10.18632/aging.101079
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Gwenael Layec, Joel D. Trinity, Corey R. Hart, Yann Le Fur, Jacob R. Sorensen, Eun-Kee Jeong, Russell S. Richardson

Abstract: The purpose of the present study was to determine whether mitochondrial function is limited by O2 availability or the intrinsic capacity of mitochondria to synthesize ATP in elderly individuals. To this aim, we examined, in comparison to free-flow conditions (FF), the effect of superimposing reactive hyperemia (RH), induced by a period of brief ischemia during the last min of exercise, on O2 availability and mitochondrial function in the calf muscle. 12 healthy, untrained, elderly subjects performed dynamic pl…

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