2016
DOI: 10.18632/aging.101079
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Abstract: The purpose of the present study was to determine whether mitochondrial function is limited by O2 availability or the intrinsic capacity of mitochondria to synthesize ATP in elderly individuals. To this aim, we examined, in comparison to free-flow conditions (FF), the effect of superimposing reactive hyperemia (RH), induced by a period of brief ischemia during the last min of exercise, on O2 availability and mitochondrial function in the calf muscle. 12 healthy, untrained, elderly subjects performed dynamic pl… Show more

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Cited by 7 publications
(6 citation statements)
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References 65 publications
(79 reference statements)
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“…In recent years, researchers have been developing a number of novel animal models for the study of cachexia caused by several underlying diseases and also for sarcopenia [ 35 ]. Our study focuses mainly on the skeletal muscle, but we cannot rule out other physiological aspects that can contribute to sarcopenia, such as the decrease in oxygen supply in the skeletal muscle that occurs in aging process [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, researchers have been developing a number of novel animal models for the study of cachexia caused by several underlying diseases and also for sarcopenia [ 35 ]. Our study focuses mainly on the skeletal muscle, but we cannot rule out other physiological aspects that can contribute to sarcopenia, such as the decrease in oxygen supply in the skeletal muscle that occurs in aging process [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…This approach has revealed a metabolic reserve in individuals with an O 2 delivery limitation (21,36,61). More recently, the influence of O 2 delivery on mitochondrial oxidative capacity, defined here as the intrinsic mitochondrial capacity for ATP synthesis, was investigated by superimposing reactive hyperemia (RH), induced by a period of brief ischemia toward the end of exercise, on the recovery from plantar flexion exercise (36,37). The consequence of this intervention was assessed with an integrative approach combining 31 P MRS, near-infrared spectroscopy (NIRS), and Doppler ultrasound.…”
Section: Introductionmentioning
confidence: 99%
“…The consequence of this intervention was assessed with an integrative approach combining 31 P MRS, near-infrared spectroscopy (NIRS), and Doppler ultrasound. RH significantly increased convective O 2 delivery and V max in both young and old healthy subjects (36,37). Interestingly, neither the impact of hyperoxia nor RH on the oxidative capacity of the skeletal muscle of patients with PAD, a population recognized to have reduced muscle O 2 saturation and perfusion (12,14), has been evaluated and could provide new insights into the role of O 2 availability and skeletal muscle mitochondrial oxidative capacity in patients with PAD.…”
Section: Introductionmentioning
confidence: 99%
“…Lowe, et al positively correlated [23] anti-in lammatory cytokine IL-17E with serum 25(OH) vitamin D insuf iciency present in the majority of term HIE neonates. Layec, et al assessed muscle metabolism and peripheral hemodynamics in healthy, untrained, elderly individuals subjected [24] to dynamic plantar lexion exercise and other imaging examinations including phosphorus magnetic resonance spectroscopy (31P-MRS). Groenendaal, et al were [25] led to the concept of secondary energy failure after phosphorus magnetic resonance spectroscopy (MRS) in infants with HIE.…”
Section: Discussionmentioning
confidence: 99%